gene

SUCLA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUCLA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

15Outgoing

12Incoming

0Experiments

0Debates

Summary

Succinate-CoA Ligase ADP Forming Subunit Beta - mitochondrial ATP synthesis enzyme in neurodegeneration

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🧬 Gene Info

Gene Symbol	SUCLA2
Full Name	Succinate-CoA Ligase ADP Forming Subunit Beta
Chromosome	13q14.2
Protein Type	Enzyme
Function	encodes the β subunit of ADP-forming succinyl-CoA synthetase (SCS), also known as succinate-CoA ligase ADP-forming GDP form
Primary Expression	tissues with high ATP demand, including brain, heart, and skeletal muscle
Molecular Weight	35 kDa
Amino Acids	30 aa
UniProt ID	P53999
NCBI Gene ID	8802
Ensembl ID	ENSG00000147576
OMIM	603921
Associated Diseases	neurodegeneration
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SUCLA2 — AlphaFold P53999 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SUCLA2 Gene

gene · 2080 words

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Pathway Diagram

graph TD
    SUCLA2["SUCLA2
Succinate-CoA Ligase"]
    SUCLG1["SUCLG1
alpha-subunit"]
    MTDNA["Mitochondrial DNA"]
    TFAM["TFAM
Transcription Factor"]
    POLG["POLG
DNA Polymerase gamma"]
    OPA1["OPA1
Mitochondrial Dynamics"]
    MFN2["MFN2
Mitofusin 2"]
    TK2["TK2
Thymidine Kinase"]
    RRM2B["RRM2B
Ribonucleotide Reductase"]
    DGUOK["DGUOK
Deoxyguanosine Kinase"]
    ALS["Amyotrophic Lateral Sclerosis"]
    NEUROPATHY["Peripheral Neuropathy"]
    ATP_SYNTHESIS["ATP Synthesis"]
    MTDNA_DEPLETION["mtDNA Depletion Syndrome"]
    MITO_DYSFUNCTION["Mitochondrial Dysfunction"]

    SUCLA2 -->|"forms complex with"| SUCLG1
    SUCLA2 -->|"catalyzes"| ATP_SYNTHESIS
    SUCLA2 -->|"mutations cause"| MTDNA_DEPLETION
    TFAM -->|"regulates"| MTDNA
    POLG -->|"replicates"| MTDNA
    TK2 -->|"provides dNTPs for"| MTDNA
    RRM2B -->|"provides dNTPs for"| MTDNA
    DGUOK -->|"provides dNTPs for"| MTDNA
    MTDNA_DEPLETION -->|"leads to"| MITO_DYSFUNCTION
    MITO_DYSFUNCTION -->|"causes"| ALS
    MITO_DYSFUNCTION -->|"causes"| NEUROPATHY
    OPA1 -->|"maintains"| MITO_DYSFUNCTION
    MFN2 -->|"maintains"| MITO_DYSFUNCTION
    ATP_SYNTHESIS -->|"impaired in"| MITO_DYSFUNCTION

    style SUCLA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style SUCLG1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style TFAM fill:#4a1a6b,stroke:#333,stroke-width:2px
    style POLG fill:#4a1a6b,stroke:#333,stroke-width:2px
    style OPA1 fill:#1b5e20,stroke:#333,stroke-width:2px
    style MFN2 fill:#1b5e20,stroke:#333,stroke-width:2px
    style ALS fill:#7d4200,stroke:#333,stroke-width:2px
    style NEUROPATHY fill:#7d4200,stroke:#333,stroke-width:2px
    style MTDNA_DEPLETION fill:#ef5350,stroke:#333,stroke-width:2px
    style MITO_DYSFUNCTION fill:#ef5350,stroke:#333,stroke-width:2px

Outgoing (15)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Neuropathy	expressed_in	disease	0.65
DNA	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
SUCLG1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RNASEH1	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
MPV17	associated_with	gene	0.60
DGUOK	associated_with	gene	0.60
RRM2B	expressed_in	gene	0.60

Incoming (12)

Source	Relation	Type	Str
POLG2	associated_with	gene	0.60
SLC25A4	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
TYMP	associated_with	gene	0.60
RRM2B	associated_with	gene	0.60
TK2	associated_with	gene	0.60
DGUOK	associated_with	gene	0.60
SUCLG1	expressed_in	gene	0.60
MPV17	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
MTDNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SUCLA2 in their description or question text

No additional research found