Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC25A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC25A4 |
| Full Name | Solute Carrier Family 25 Member 4 (Adenine Nucleotide Translocator 1) |
| Chromosome | 4q31.21 |
| Function | is a mitochondrial carrier protein that catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane. |
| Primary Expression | High expression in heart, skeletal muscle, brain; tissues with high energy demands |
| Molecular Weight | 33 kDa |
| Amino Acids | 298 aa |
| UniProt ID | P12235 |
| NCBI Gene ID | 291 |
| Ensembl ID | ENSG00000151729 |
| OMIM | 103220 |
| GeneCards | SLC25A4 |
| Human Protein Atlas | SLC25A4 |
| Associated Diseases | translational_neuroscience |
| SciDEX Hypotheses | Mitochondrial ATP/ADP Carrier Activity as Bioenerg |
| KG Connections | 25 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC25A4["SLC25A4 (ANT1)
ADP/ATP Translocase"]
ATP_Transport["ATP/ADP Transport
Across Inner Membrane"]
Mito_Energetics["Mitochondrial
Bioenergetics"]
POLG["POLG
DNA Polymerase gamma"]
TFAM["TFAM
Transcription Factor"]
TWNK["TWNK
Twinkle Helicase"]
mtDNA["Mitochondrial DNA
Maintenance"]
OPA1["OPA1
Fusion Protein"]
MFN2["MFN2
Mitofusin 2"]
Mito_Dynamics["Mitochondrial
Dynamics"]
TK2["TK2
Thymidine Kinase"]
dNTP_Pool["dNTP Pool
Maintenance"]
Mito_Dysfunction["Mitochondrial
Dysfunction"]
Neurodegeneration["Neurodegeneration"]
SLC25A4 -->|"facilitates"| ATP_Transport
ATP_Transport -->|"maintains"| Mito_Energetics
SLC25A4 -->|"interacts with"| POLG
POLG -->|"replicates"| mtDNA
TFAM -->|"regulates"| mtDNA
TWNK -->|"unwinds"| mtDNA
SLC25A4 -->|"coordinates with"| OPA1
OPA1 -->|"promotes"| Mito_Dynamics
MFN2 -->|"mediates"| Mito_Dynamics
TK2 -->|"maintains"| dNTP_Pool
dNTP_Pool -->|"supports"| mtDNA
SLC25A4 -->|"dysfunction leads to"| Mito_Dysfunction
Mito_Dysfunction -->|"causes"| Neurodegeneration
style SLC25A4 fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
style ATP_Transport fill:#1b5e20
style Mito_Energetics fill:#1b5e20
style POLG fill:#4a1a6b
style TFAM fill:#4a1a6b
style OPA1 fill:#4a1a6b
style MFN2 fill:#4a1a6b
style TK2 fill:#4a1a6b
style TWNK fill:#4a1a6b
style Mito_Dysfunction fill:#ef5350
style Neurodegeneration fill:#7d4200| Target | Relation | Type | Str |
|---|---|---|---|
| Immune Response | contributes_to | pathway | 0.60 |
| Macrophage | contributes_to | cell_type | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| translational_neuroscience | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GATA2 | contributes_to | gene | 0.60 |
| KCNN4 | contributes_to | gene | 0.60 |
| POLG2 | associated_with | gene | 0.60 |
| h-f7da6372 | targets | hypothesis | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial ATP/ADP Carrier Activity as Bioenergetic Recov | 0.642 | translational neuroscience | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.829
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning SLC25A4 in their description or question text
No additional research found