gene

SUCLG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUCLG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

34Outgoing

24Incoming

0Experiments

0Debates

Summary

α subunit of succinyl-CoA synthetase essential for TCA cycle and mitochondrial GTP synthesis

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🧬 Gene Info

Gene Symbol	SUCLG1
Full Name	Succinate-CoA Ligase GDP Forming Subunit Alpha
Chromosome	2p11.2
Protein Family	Succinate-CoA ligase family
Function	of 463 amino acids with a molecular weight of ~50 kDa
Molecular Weight	50 kDa
Amino Acids	463 aa
Exons	13
Pathways	Apoptosis, Immune Response, Nf-Κb
UniProt ID	[P53567](https://www.uniprot.org/uniprot/P53567)
Ensembl ID	ENSG00000153558
OMIM	605172
GeneCards	SUCLG1
Human Protein Atlas	SUCLG1
Associated Diseases	neurodegeneration
Interactions	ACO2, ALZHEIMER, ALZHEIMER'S DISEASE, APP, APP/PS1, ATP
KG Connections	58 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SUCLG1 — Succinate-CoA Ligase GDP Forming Subunit Alpha

gene · 1105 words

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Pathway Diagram

graph TD
    SUCLG1["SUCLG1"]
    Ischemia{"Ischemia"}
    SUCLG1 -->|"regulates"| Ischemia
    Ms{"Ms"}
    SUCLG1 -->|"therapeutic target"| Ms
    Cardiac{"Cardiac"}
    SUCLG1 -->|"regulates"| Cardiac
    Inflammation{"Inflammation"}
    SUCLG1 -->|"regulates"| Inflammation
    Alzheimer{"Alzheimer"}
    SUCLG1 -->|"inhibits"| Alzheimer
    Als{"Als"}
    SUCLG1 -->|"activates"| Als
    SUCLG1 -->|"expressed in"| Ms
    GAIN["GAIN"]
    SUCLG1 -->|"regulates"| GAIN
    TLR4["TLR4"]
    SUCLG1 -->|"regulates"| TLR4
    Immune_Response(["Immune Response"])
    SUCLG1 -->|"regulates"| Immune_Response
    Nf__b(["Nf-Kappab"])
    SUCLG1 -->|"regulates"| Nf__b
    Apoptosis(["Apoptosis"])
    SUCLG1 -->|"regulates"| Apoptosis
    __HYDROXYBUTYRATE["Beta-HYDROXYBUTYRATE"]
    __HYDROXYBUTYRATE -->|"activates"| SUCLG1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| SUCLG1
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"inhibits"| SUCLG1
    APP["APP"]
    APP -->|"inhibits"| SUCLG1
    style SUCLG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Neuropathy	expressed_in	disease	0.65
Ischemia	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
TK2	associated_with	gene	0.60
TYMP	associated_with	gene	0.60
MPV17	expressed_in	gene	0.60
SUCLA2	expressed_in	gene	0.60
RRM2B	expressed_in	gene	0.60
STX17	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
Immune Response	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
DNA	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
POLG	associated_with	gene	0.60
RNASEH1	associated_with	gene	0.60
OPA1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
MPV17	associated_with	gene	0.60
DGUOK	associated_with	gene	0.60
ATP	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
GAIN	regulates	gene	0.60
TLR4	regulates	gene	0.60

Incoming (24)

Source	Relation	Type	Str
APP	inhibits	gene	0.60
POLG2	associated_with	gene	0.60
SLC25A4	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
TYMP	associated_with	gene	0.60
RRM2B	associated_with	gene	0.60
TK2	associated_with	gene	0.60
SUCLA2	associated_with	gene	0.60
DGUOK	associated_with	gene	0.60
ACO2	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
MTDNA	associated_with	gene	0.60
ATP	activates	gene	0.60
MDH2	interacts_with	gene	0.60
NDUFS3	interacts_with	gene	0.60
PDHB	interacts_with	gene	0.60
SDHA	interacts_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
Β-HYDROXYBUTYRATE	activates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APP/PS1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SUCLG1 in their description or question text

No additional research found