protein

FANCD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FANCD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

Summary

FANCD2 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with ALS, Als, Cancer. Connected to 49 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FANCD2
Full Name	Fanconi Anemia Group D2
Chromosome	3p25.3
Function	FANCD2 is a key protein in the Fanconi anemia (FA) DNA repair pathway, which is essential for resolving DNA interstrand crosslinks (ICLs).
Primary Expression	most tissues, with high expression in:
Molecular Weight	164 kDa
Amino Acids	1451 aa
Pathways	Dna Damage Response, Ferroptosis, Ferroptosis Pathway, Reactive Oxygen Species, autophagy pathway
UniProt ID	FANCD2
Ensembl ID	ENSG00000144554
OMIM	227646
GeneCards	FANCD2
Human Protein Atlas	FANCD2
DNA Interstrand Crosslink Repair	FANCD2 monoubiquitination is required for ICL repair during S and G2 phases
Homologous Recombination	Facilitates HR repair of double-strand breaks
Associated Diseases	Carcinoma, Tumor
Interactions	ALOX, AND, App, ATG, CANCER, DNA
KG Connections	102 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FANCD2 — AlphaFold FANCD2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FANCD2 Gene

gene · 572 words

→

FANCD2 Protein

protein · 1202 words

→

Pathway Diagram

graph TD
    FANCD2["FANCD2"]
    Cancer{"Cancer"}
    FANCD2 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    FANCD2 -->|"associated with"| Carcinoma
    Als{"Als"}
    FANCD2 -->|"activates"| Als
    FANCD2 -->|"therapeutic target"| Als
    FANCD2 -->|"therapeutic target"| Cancer
    FANCD2 -->|"interacts with"| Als
    FANCD2 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    FANCD2 -->|"associated with"| Tumor
    ALS{"ALS"}
    FANCD2 -->|"activates"| ALS
    STING1["STING1"]
    FANCD2 -->|"associated with"| STING1
    TFAM["TFAM"]
    FANCD2 -->|"associated with"| TFAM
    POLG["POLG"]
    FANCD2 -->|"associated with"| POLG
    MAP1LC3B["MAP1LC3B"]
    MAP1LC3B -->|"associated with"| FANCD2
    GPX4["GPX4"]
    GPX4 -->|"associated with"| FANCD2
    BMAL1["BMAL1"]
    BMAL1 -->|"associated with"| FANCD2
    LC3["LC3"]
    LC3 -->|"associated with"| FANCD2
    NCOA4["NCOA4"]
    NCOA4 -->|"associated with"| FANCD2
    ARNTL["ARNTL"]
    ARNTL -->|"associated with"| FANCD2
    CGAS["CGAS"]
    CGAS -->|"associated with"| FANCD2
    SLC7A11["SLC7A11"]
    SLC7A11 -->|"associated with"| FANCD2
    TMEM173["TMEM173"]
    TMEM173 -->|"associated with"| FANCD2
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"associated with"| FANCD2
    ALOX["ALOX"]
    ALOX -->|"associated with"| FANCD2
    ATM["ATM"]
    ATM -->|"associated with"| FANCD2
    style FANCD2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
Carcinoma	associated_with	disease	0.65
Als	activates	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	activates	disease	0.65
TUFM	interacts_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
FANCA	interacts_with	gene	0.60
ARNTL	associated_with	gene	0.60
ROS	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
MAP1LC3B	activates	entity	0.60
NCOA4	activates	entity	0.60
POLG	activates	entity	0.60
SLC7A11	activates	entity	0.60
STING1	activates	entity	0.60
TFAM	activates	entity	0.60
TMEM173	activates	entity	0.60
GPX4	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
FANCI	regulates	gene	0.60
AND	activates	gene	0.60
GPX4	activates	entity	0.60
Ras	associated_with	protein	0.60
App	activates	protein	0.60
ROS	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
Rb	associated_with	protein	0.60
LC3	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
SLC7A11	associated_with	gene	0.60
LC3	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
Ferroptosis Pathway	activates	pathway	0.60
Complement	associated_with	pathway	0.60
Ferroptosis	activates	pathway	0.60
Autophagy	associated_with	pathway	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
Mitochondrial Function	interacts_with	pathway	0.60
ALOX	associated_with	gene	0.60
Interferon	associated_with	protein	0.60
STING1	associated_with	gene	0.60

Incoming (38)

Source	Relation	Type	Str
FAN1	regulates	gene	0.60
POLG	associated_with	gene	0.60
STING1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
ATM	associated_with	gene	0.60
ARNTL	activates	entity	0.60
ATM	activates	entity	0.60
BMAL1	activates	entity	0.60
CGAS	activates	entity	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
ALOX	activates	gene	0.60
ATG	activates	gene	0.60
DNA	activates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
ROS	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
MTDNA	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ALOX	associated_with	gene	0.60
ATG	associated_with	gene	0.60
Autophagy	activates	process	0.50
SLC7A11	activates	gene	0.50
GPX4	activates	gene	0.50
TMEM173	activates	gene	0.50
TFAM	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
POLG	activates	gene	0.50
STING1	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FANCD2 in their description or question text

No additional research found