Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TK2 |
| Full Name | Thymidine Kinase 2 |
| Protein Type | Protein |
| Function | Thymidine kinase 2 (TK2) is a mitochondrial enzyme that catalyzes the phosphorylation of thymidine, deoxyuridine, and deoxycytidine. |
| Molecular Weight | 62 kDa |
| Amino Acids | 265 aa |
| UniProt ID | Search UniProt |
| GeneCards | TK2 |
| Human Protein Atlas | TK2 |
| Associated Diseases | neurodegeneration |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TK2["TK2
Thymidine Kinase 2"]
MTDNA["Mitochondrial DNA"]
DNTP_POOL["dNTP Pool"]
MIT_REP["Mitochondrial DNA
Replication"]
MIT_DEPL["mtDNA Depletion"]
POLG["POLG
DNA Polymerase gamma"]
TFAM["TFAM
Transcription Factor"]
TWNK["TWNK
Twinkle Helicase"]
RRM2B["RRM2B
Ribonucleotide Reductase"]
DGUOK["DGUOK
Deoxyguanosine Kinase"]
TYMP["TYMP
Thymidine Phosphorylase"]
MIT_DYSFUNC["Mitochondrial
Dysfunction"]
MYOPATHY["Mitochondrial
Myopathy"]
NEUROPATHY["Peripheral
Neuropathy"]
ALS["ALS
Motor Neuron Disease"]
OPA1["OPA1
Mitochondrial Dynamics"]
MFN2["MFN2
Mitofusin 2"]
TK2 -->|"phosphorylates"| DNTP_POOL
DNTP_POOL -->|"provides substrates"| MIT_REP
POLG -->|"synthesizes"| MIT_REP
TFAM -->|"initiates"| MIT_REP
TWNK -->|"unwinds DNA"| MIT_REP
MIT_REP -->|"maintains"| MTDNA
TK2 -->|"deficiency causes"| MIT_DEPL
MIT_DEPL -->|"leads to"| MIT_DYSFUNC
MIT_DYSFUNC -->|"manifests as"| MYOPATHY
MIT_DYSFUNC -->|"causes"| NEUROPATHY
MIT_DYSFUNC -->|"associated with"| ALS
RRM2B -->|"provides dNTPs"| DNTP_POOL
DGUOK -->|"salvage pathway"| DNTP_POOL
TYMP -->|"regulates nucleotide
metabolism"| DNTP_POOL
MIT_DYSFUNC -->|"affects"| OPA1
MIT_DYSFUNC -->|"disrupts"| MFN2
style TK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
style DNTP_POOL fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style MIT_REP fill:#1b5e20,stroke:#4caf50,stroke-width:2px
style POLG fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style TFAM fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style TWNK fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style RRM2B fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style DGUOK fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style TYMP fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
style MIT_DEPL fill:#ef5350,stroke:#f44336,stroke-width:2px
style MIT_DYSFUNC fill:#ef5350,stroke:#f44336,stroke-width:2px
style MYOPATHY fill:#7d4200,stroke:#ff9800,stroke-width:2px
style NEUROPATHY fill:#7d4200,stroke:#ff9800,stroke-width:2px
style ALS fill:#7d4200,stroke:#ff9800,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Neuropathy | expressed_in | disease | 0.65 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| MPV17 | expressed_in | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| POLG2 | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| RRM2B | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TK2 in their description or question text
No additional research found