Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RRM2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RRM2B gene encoding p53-inducible ribonucleotide reductase subunit M2B - critical for mitochondrial DNA maintenance and dNTP synthesis
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| Gene Symbol | RRM2B |
| Full Name | Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B |
| Aliases | RRM2B gene encoding p53-inducible ribonucleotide reductase subunit M2B |
| Chromosome | 8q23.1 |
| Protein Type | Enzyme |
| Function | encodes a critical enzyme in nucleotide metabolism, specifically the p53-inducible small subunit of ribonucleotide reductase (RNR). |
| Primary Expression | most human tissues, with highest levels in: - Skeletal muscle: High mitochondrial content and energy demand - Heart: Continuous oxidative phos |
| Molecular Weight | 45 kDa |
| Amino Acids | 389 aa |
| UniProt ID | Q7LG56 |
| NCBI Gene ID | 50484 |
| Ensembl ID | ENSG00000068912 |
| OMIM | 604712 |
| GeneCards | RRM2B |
| Human Protein Atlas | RRM2B |
| Associated Diseases | neurodegeneration |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RRM2B["RRM2B
(Ribonucleotide Reductase M2 B)"]
%% DNA synthesis pathway
TK2["TK2
(Thymidine Kinase 2)"]
DGUOK["DGUOK
(Deoxyguanosine Kinase)"]
TYMP["TYMP
(Thymidine Phosphorylase)"]
%% Mitochondrial DNA maintenance
POLG["POLG
(DNA Polymerase Gamma)"]
POLG2["POLG2
(DNA Polymerase Gamma 2)"]
TFAM["TFAM
(Transcription Factor A)"]
TWNK["TWNK
(Twinkle Helicase)"]
MTDNA["Mitochondrial DNA
Replication"]
%% Mitochondrial function
OPA1["OPA1
(Optic Atrophy 1)"]
MFN2["MFN2
(Mitofusin 2)"]
MPV17["MPV17
(Mitochondrial Protein)"]
%% Disease outcomes
Als["Amyotrophic Lateral
Sclerosis"]
Neuropathy["Mitochondrial
Neuropathy"]
%% Central pathways
RRM2B -->|"provides dNTPs for"| MTDNA
TK2 -->|"salvage pathway"| MTDNA
DGUOK -->|"salvage pathway"| MTDNA
TYMP -->|"regulates nucleotide pool"| MTDNA
POLG -->|"replicates"| MTDNA
POLG2 -->|"accessory subunit"| POLG
TFAM -->|"packages and maintains"| MTDNA
TWNK -->|"unwinds DNA for"| MTDNA
OPA1 -->|"maintains structure"| MTDNA
MFN2 -->|"fusion affects"| MTDNA
MPV17 -->|"nucleotide transport"| MTDNA
MTDNA -->|"depletion causes"| Als
MTDNA -->|"mutations cause"| Neuropathy
%% Styling
style RRM2B fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
style MTDNA fill:#1b5e20,stroke:#4caf50,color:#e0e0e0
style TK2 fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
style DGUOK fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
style POLG fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
style TFAM fill:#4a1a6b,stroke:#9c27b0,color:#e0e0e0
style Als fill:#7d4200,stroke:#ff9800,color:#e0e0e0
style Neuropathy fill:#7d4200,stroke:#ff9800,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Neuropathy | expressed_in | disease | 0.65 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| SUCLA2 | associated_with | gene | 0.60 |
| SUCLG1 | associated_with | gene | 0.60 |
| TFAM | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| RNASEH1 | associated_with | gene | 0.60 |
| OPA1 | associated_with | gene | 0.60 |
| TWNK | associated_with | gene | 0.60 |
| MPV17 | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOCHONDRIAL DNA | expressed_in | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| POLG2 | associated_with | gene | 0.60 |
| SLC25A4 | associated_with | gene | 0.60 |
| MFN2 | associated_with | gene | 0.60 |
| TYMP | associated_with | gene | 0.60 |
| DGUOK | associated_with | gene | 0.60 |
| SUCLG1 | expressed_in | gene | 0.60 |
| TK2 | associated_with | gene | 0.60 |
| MPV17 | expressed_in | gene | 0.60 |
| SUCLA2 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RRM2B in their description or question text
No additional research found