gene

PDGFRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

1Hypotheses

0Analyses

50Outgoing

33Incoming

3Experiments

0Debates

Summary

Page for PDGFRA - Platelet Derived Growth Factor Receptor Alpha

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🧬 Gene Info

Gene Symbol	PDGFRA
Full Name	Platelet-Derived Growth Factor Receptor Alpha
Aliases	Page for PDGFRA
Chromosome	4q12
Protein Type	Gene
Function	PDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]:
Primary Expression	mesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references]
Molecular Weight	180 kDa
Amino Acids	1086 aa
Exons	23
Pathways	Akt, Differentiation, MAPK signaling, ubiquitin-proteasome
GeneCards	PDGFRA
Human Protein Atlas	PDGFRA
Extracellular domain	Five immunoglobulin-like (Ig) domains that mediate ligand binding and receptor dimerization
Transmembrane domain	Single pass alpha-helical transmembrane region
Associated Diseases	ALS, Cancer, Carcinoma, Glioma, Tumor
Interactions	AKT, AKT3, AND, App, CANCER, CDKN2A
SciDEX Hypotheses	OPC differentiation blockade contributes to white
KG Connections	104 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PDGFRA — Platelet-Derived Growth Factor Receptor Alpha

protein · 842 words

→

PDGFRA - Platelet Derived Growth Factor Receptor Alpha

gene · 630 words

→

Pathway Diagram

graph TD
    PDGFRA["PDGFRA"]
    Ms{"Ms"}
    PDGFRA -->|"interacts with"| Ms
    Als{"Als"}
    PDGFRA -->|"regulates"| Als
    Cancer{"Cancer"}
    PDGFRA -->|"activates"| Cancer
    Tumor{"Tumor"}
    PDGFRA -->|"activates"| Tumor
    PDGFRA -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    PDGFRA -->|"associated with"| Carcinoma
    PDGFRA -->|"inhibits"| Ms
    Glioblastoma{"Glioblastoma"}
    PDGFRA -->|"therapeutic target"| Glioblastoma
    ALS{"ALS"}
    PDGFRA -->|"regulates"| ALS
    PDGFRB["PDGFRB"]
    PDGFRA -->|"interacts with"| PDGFRB
    P53["P53"]
    PDGFRA -->|"regulates"| P53
    THBS2["THBS2"]
    PDGFRA -->|"associated with"| THBS2
    GLI1["GLI1"]
    GLI1 -->|"regulates"| PDGFRA
    PDGFRB -->|"interacts with"| PDGFRA
    P53 -->|"regulates"| PDGFRA
    GRIK3["GRIK3"]
    GRIK3 -->|"inhibits"| PDGFRA
    ERK["ERK"]
    ERK -->|"inhibits"| PDGFRA
    SRC["SRC"]
    SRC -->|"activates"| PDGFRA
    GRID2["GRID2"]
    GRID2 -->|"inhibits"| PDGFRA
    THBS2 -->|"regulates"| PDGFRA
    NEURON["NEURON"]
    NEURON -->|"activates"| PDGFRA
    RAS["RAS"]
    RAS -->|"inhibits"| PDGFRA
    CANCER["CANCER"]
    CANCER -->|"activates"| PDGFRA
    AND["AND"]
    AND -->|"inhibits"| PDGFRA
    style PDGFRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (71)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PDGFRA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Tumor	activates	disease	0.75
Als	regulates	disease	0.65
Glioma	activates	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Cancer	causes	disease	0.65
ALS	regulates	disease	0.65
Ms	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	causes	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Raf	inhibits	protein	0.60
Pdgf	expressed_in	protein	0.60
Fgf	inhibits	protein	0.60
App	inhibits	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
PDGFRB	interacts_with	gene	0.60
PI3K	associated_with	gene	0.60
AKT	associated_with	gene	0.60
IL6R	activates	gene	0.60
AKT	activates	gene	0.60
EPHA2	inhibits	gene	0.60
GBM	inhibits	gene	0.60
PDGFA	inhibits	gene	0.60
GLI1	regulates	gene	0.60
PDGFRB	contributes_to	entity	0.60
MYC	activates	gene	0.60
JUN	activates	gene	0.60
Rb	interacts_with	protein	0.60
NRG1	expressed_in	gene	0.60
Rb	inhibits	protein	0.60
PDGFRB	implicated_in	gene	0.60
TP53	associated_with	gene	0.60
SETD2	associated_with	gene	0.60
PTEN	activates	gene	0.60
TERT	activates	gene	0.60
TP53	activates	gene	0.60
Pi3K	associated_with	pathway	0.60
Akt	activates	pathway	0.60
THBS2	regulates	gene	0.60
Differentiation	activates	pathway	0.60
PDGF	interacts_with	gene	0.60
AND	interacts_with	gene	0.60

Incoming (33)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PDGFRA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
h_seaad_004	targets_gene	hypothesis	0.90
CANCER	activates	gene	0.60
GENES	expressed_in	gene	0.60
PDGF	interacts_with	gene	0.60
ONCOGENES	expressed_in	gene	0.60
MYCN	associated_with	gene	0.60
MAPK	inhibits	gene	0.60
ERK	inhibits	gene	0.60
NEURON	activates	gene	0.60
RAS	inhibits	gene	0.60
CDKN2A	activates	gene	0.60
MDM4	activates	gene	0.60
P53	regulates	gene	0.60
THBS2	regulates	gene	0.60
GLI1	regulates	gene	0.60
PDGFRB	interacts_with	gene	0.60
GRIK3	inhibits	gene	0.60
SRC	activates	gene	0.60
GRID2	inhibits	gene	0.60
AKT	activates	gene	0.60
MYC	activates	gene	0.60
JUN	activates	gene	0.60
ATRX	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
NF1	associated_with	gene	0.60
AKT3	activates	gene	0.60
P53	co_expressed_with	protein	0.50
GLI1	co_expressed_with	gene	0.50
PDGFRB	associated_with	gene	0.50
AGER	associated_with	gene	0.30

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
OPC differentiation blockade contributes to white matter deg	0.599	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice	validation	Alzheimer's disease	0.950	APP/PS1 transgenic mice (8 mon	proposed	N/A
PDGFRA and C-MYC protein validation in ovarian cancer tissues	exploratory	Ovarian cancer	0.850	Human ovarian cancer tissues	proposed	N/A
CD2AP expression and cognitive decline in AD patients	exploratory	Alzheimer's disease	0.800	human patients	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149]	Li C, Teng T, Lin X, Sun X, Yi T et al.	Cancer Res	2026
A cellular epigenetic classification system for glioblastoma. [PMID:41499453]	Silverbush D, Jürgensen L, Freeburg NF,	Neuro Oncol	2026
Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491]	Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan	J Gastroenterol Hepatol	2026
P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526]	Yan L, Zheng J, Lu Z, Zhu A, Ye M et al.	Circulation	2026
Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834]	Ye D, Zhou H, Qu S, Wang Z, Zhang F et a	Cell Death Discov	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDGFRA in their description or question text

No additional research found