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gene 685 words KG: NRG1
Contents

NRG1 Gene

🧬 Gene Info
Gene SymbolNRG1
Chromosome8p21
Protein FamilyNeuregulin family
FunctionInduces receptor dimerization
Amino Acids50 aa
Exons20
PathwaysPI3K, MAPK
UniProt IDQ7MZ64
NCBI Gene ID3084
Ensembl IDENSG00000157140
GeneCardsNRG1
Human Protein AtlasNRG1
Associated DiseasesAls, Bipolar, Bipolar Disorder, BIPOLAR_DISORDER, Depression
InteractionsADRA1A, ADRA2A, ADRB1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
KG Connections221 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Noradrenergic-Tau Propagation Blockade
Score: 0.71Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Epigenetic Memory Erasure via TET2 Activation
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Oligodendrocyte White Matter Vulnerability
Score: 0.65

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

ATP P2X3 Receptor Neurons
cell · KG edge: regulatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibitsBDNF Gene
gene · KG edge: associated_withBMAL1 (ARNTL) Gene
gene · KG edge: associated_withBRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

NRG1 associated_with BIPOLAR_DISORDER
HTR2A associated_with NRG1
DISC1 associated_with NRG1
FKBP5 associated_with NRG1
NRG1 associated_with DAO
NRG1 associated_with BMAL1
NRG1 associated_with GRM4
NRG1 associated_with SYNGR1
NRG1 associated_with BDNF
NRG1 associated_with NCAM1

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