gene

RET

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

25Hypotheses

0Analyses

50Outgoing

44Incoming

8Experiments

0Debates

Summary

RET is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Cancer, Carcinoma. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RET
Chromosome	10q11.21
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	120 kDa
Amino Acids	114 aa
Exons	21
Pathways	PI3K, mTOR, mtor, MAPK
GeneCards	RET
Human Protein Atlas	RET
Associated Diseases	Als, Ataxia, Melanoma, Ms, Parkinson
Interactions	AKT, AND, APOPTOSIS, CANCER, CDKN2A, DNA
KG Connections	133 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RET["RET"]
    Als{"Als"}
    RET -->|"inhibits"| Als
    Neuropathy{"Neuropathy"}
    RET -->|"inhibits"| Neuropathy
    Ms{"Ms"}
    RET -->|"activates"| Ms
    Cancer{"Cancer"}
    RET -->|"activates"| Cancer
    Tumor{"Tumor"}
    RET -->|"inhibits"| Tumor
    ERBB2["ERBB2"]
    RET -->|"inhibits"| ERBB2
    GENES["GENES"]
    RET -->|"associated with"| GENES
    ERBB3["ERBB3"]
    RET -->|"inhibits"| ERBB3
    NRG1["NRG1"]
    RET -->|"inhibits"| NRG1
    CANCER["CANCER"]
    RET -->|"activates"| CANCER
    EGFR["EGFR"]
    RET -->|"activates"| EGFR
    AND["AND"]
    RET -->|"inhibits"| AND
    style RET fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (89)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.80
apoptosis pathway	participates_in	pathway	0.70
neurodegeneration	regulates	disease	0.70
GENES	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
EGFR	activates	gene	0.70
Neuropathy	inhibits	disease	0.65
Autoimmune	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Als	inhibits	disease	0.65
Melanoma	associated_with	disease	0.65
Tumor	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Neuropathy	transports	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Glioma	regulates	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
CANCER	therapeutic_target	gene	0.60
RIPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
RIPK1	inhibits	gene	0.60
RIPK3	inhibits	gene	0.60
Mismatch Repair	expressed_in	pathway	0.60
Epithelial-Mesenchymal Transition	regulates	pathway	0.60
Egfr Signaling	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Invasion	activates	pathway	0.60
TNF-Α	activates	gene	0.60
ERBB3	inhibits	gene	0.60
HIF	regulates	gene	0.60
DJ-1	associated_with	gene	0.60
AND	inhibits	gene	0.60
MAP1B	transports	gene	0.60
TAU	transports	gene	0.60
DYNEIN	transports	gene	0.60
TRKB	regulates	gene	0.60
TRKC	regulates	gene	0.60
Schwann Cell	expressed_in	cell_type	0.60
Dynein	transports	protein	0.60
AND	associated_with	gene	0.60
ALPHA-SYNUCLEIN	associated_with	gene	0.60

Incoming (44)

Source	Relation	Type	Str
genes-ret	describes	wiki_page	1.00
genes-ret	documents	wiki_page	1.00
GDNF	activates	gene	0.80
GDNF	regulates	gene	0.70
AKT	protects_against	gene	0.60
ERK1	protects_against	gene	0.60
GDNF	protects_against	gene	0.60
GFRA1	protects_against	gene	0.60
ERK	regulates	gene	0.60
AKT	activates	gene	0.60
AKT	interacts_with	gene	0.60
ERK1	interacts_with	gene	0.60
GDNF	interacts_with	gene	0.60
GFRA1	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
GDNF	expressed_in	gene	0.60
GDNF	inhibits	gene	0.60
PI3K	protects_against	gene	0.60
MLKL	activates	gene	0.60
MLKL	inhibits	gene	0.60
GFRA1	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
GSK3	activates	gene	0.60
MYO5A	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
CDKN2A	interacts_with	gene	0.60
PTEN	expressed_in	gene	0.60
BRAF	therapeutic_target	gene	0.60
TRKA	regulates	gene	0.60
CD33	regulates	gene	0.60
CD55	regulates	gene	0.60
EPHA1	regulates	gene	0.60
PILRA	regulates	gene	0.60
PILRB	regulates	gene	0.60
PKC	associated_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
CDK5	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
MYELIN	expressed_in	gene	0.60
CANCER	associated_with	disease	0.50

Targeting Hypotheses (25)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte	0.839	neurodegeneration	View
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
Metabolic-Support Secretome Dysfunction	0.730	neurodegeneration	Which specific factors in conditioned me
SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M	0.720	neurodegeneration	How can senescent microglia be molecular
Retinal Vascular Microcirculation Rescue	0.718	neurodegeneration	Digital biomarkers and AI-driven early d

Pericyte-targeted senolysis or senomorphic therapy will bene	0.700	neurodegeneration	Does pericyte senescence drive BBB break
APOE4-driven lysosome-to-ER cholesterol transport failure re	0.690	molecular biology	Does APOE4's reduced lipid-binding direc
Rab27A/B-mediated exosomal tau secretion from microglia driv	0.690	neurodegeneration	Which tau propagation mechanism predomin
Hypocretin-Neurogenesis Coupling Therapy	0.688	neurodegeneration	Sleep disruption as cause and consequenc
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.682	ALS	What are the mechanisms by which microgl
Axonal Transport Defect: C9orf72 hexanucleotide expansion im	0.660	neurodegeneration	What are the neuron-specific effects of
Clusterin (APOJ) Secretion Deficit	0.660	neurodegeneration	Which specific factors in conditioned me
Retromer-dependent retrograde endosomal signaling compartmen	0.620	neuroscience	How can subcellular compartmentalization
Astrocyte LRP1-mediated tau uptake and APOE4-dependent secre	0.610	neurodegeneration	Which tau propagation mechanism predomin
GFAP Perivascular Redistribution (End-Feet Retraction) as Tr	0.594	-	Blood-brain barrier permeability changes
TBK1 Phosphorylation State Creates Phospho-Regulated Periphe	0.577	neurodegeneration	What determines the spatial organization
P2RX7-Mediated Exosome Secretion Blockade	0.552	neurodegeneration	Tau propagation mechanisms and therapeut
P2Y6R activation by UDP from damaged neurons drives microgli	0.540	neurodegeneration	Which tau propagation mechanism predomin
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti	0.540	neurodegeneration	epigenetic reprogramming aging neurons
GDNF-RET Trophic Signaling Deficit	0.530	neurodegeneration	Which specific factors in conditioned me
VPS35 Retromer Restoration to Rescue Endosomal Protein Traff	0.506	proteomics	Quantitative proteomics of the aging syn
TYROBP Network Hyperactivation Marks Point of No Return	0.463	neurodegeneration	What is the optimal therapeutic window f
HSP70/HSP40 Chaperone Complex Secretion	0.380	neurodegeneration	Which specific factors in conditioned me
P2RY12 activation induces cellular senescence in cerebral VS	0.373	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Reticulocalbin-2 bridges calcineurin to lysosomal membranes	0.360	neurodegeneration	What determines the specificity of calci

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$130,000
Prodromal Parkinson's Disease Biomarker Development — Early Detection	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043]	Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY	Stem Cell Res Ther	2025	1
Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152]	Kan T, He Z, Du J, Xu M, Cui J, Han X, T	J Orthop Translat	2022	1
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989]	Yang H, Lee WS, Kong SJ, Kim CG, Kim JH,	J Clin Invest	2019	1
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026	0
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026	0
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026	0
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026	0
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480]	["De Coninck S", "De Smedt R", "Linterma	Haematologica	2024	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RET in their description or question text

RET

Understanding Entity Pages

Summary

Wiki Pages (3)

RET Gene

RETREG3 (Reticulophagy Regulator 3)

RET Protein

Pathway Diagram

Outgoing (89)

Incoming (44)

Targeting Hypotheses (25)

Mentioning Analyses (0)

Experiments (8)

Related Papers (20)

Debates (0)

Related Research

Pericyte-targeted senolysis or senomorphic therapy will benefit only an early bi

APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible

Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr

Hypocretin-Neurogenesis Coupling Therapy

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

Axonal Transport Defect: C9orf72 hexanucleotide expansion impairs retrograde aut

Clusterin (APOJ) Secretion Deficit

Retromer-dependent retrograde endosomal signaling compartmentalization as biomar

Astrocyte LRP1-mediated tau uptake and APOE4-dependent secretion creates regiona

GFAP Perivascular Redistribution (End-Feet Retraction) as True BBB Dysfunction B

TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Thresh

P2RX7-Mediated Exosome Secretion Blockade

P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and

Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigenetic Age and Restores V

GDNF-RET Trophic Signaling Deficit