gene

SENP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SENP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

1Hypotheses

0Analyses

50Outgoing

16Incoming

0Experiments

0Debates

Summary

SENP1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Als, Cancer, Colorectal Cancer. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SENP1
Full Name	SUMO Specific Peptidase 1
Aliases	Page for SENP1 Protein
Chromosome	2q33.1
Protein Family	SENP family (SUMO proteases)
Protein Type	Protease
Function	is a cysteine protease that catalyzes deSUMOylation—the removal of SUMO (Small Ubiquitin-Like Modifier) proteins from target substrates.
Molecular Weight	71 kDa
Amino Acids	482 aa
Pathways	Apoptosis, Mitophagy, Mtor, Oxidative Stress
UniProt ID	[Q9Y5W4](https://www.uniprot.org/uniprot/Q9Y5W4)
Ensembl ID	ENSG00000142405
GeneCards	SENP1
Human Protein Atlas	SENP1
N-terminal domain	Regulatory, determines substrate specificity
Associated Diseases	neurodegeneration
Interactions	AKT, AMPK, AND, APOPTOSIS, CANCER, CHIP
KG Connections	79 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SENP1 — SUMO Specific Peptidase 1

gene · 877 words

→

SENP1 Protein - SUMO Specific Peptidase 1

protein · 599 words

→

Pathway Diagram

graph TD
    SENP1["SENP1"]
    MANF["MANF"]
    SENP1 -->|"modifies"| MANF
    Als{"Als"}
    SENP1 -->|"regulates"| Als
    Cancer{"Cancer"}
    SENP1 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    SENP1 -->|"regulates"| Tumor
    Fibrosis{"Fibrosis"}
    SENP1 -->|"activates"| Fibrosis
    Ischemia{"Ischemia"}
    SENP1 -->|"activates"| Ischemia
    Inflammation{"Inflammation"}
    SENP1 -->|"activates"| Inflammation
    PARKIN["PARKIN"]
    SENP1 -->|"regulates"| PARKIN
    UBIQUITIN["UBIQUITIN"]
    SENP1 -->|"regulates"| UBIQUITIN
    MITOPHAGY["MITOPHAGY"]
    SENP1 -->|"regulates"| MITOPHAGY
    CANCER["CANCER"]
    SENP1 -->|"regulates"| CANCER
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    SENP1 -->|"regulates"| OXIDATIVE_STRESS
    PIN1["PIN1"]
    PIN1 -->|"binds"| SENP1
    MFN1["MFN1"]
    MFN1 -->|"inhibits"| SENP1
    style SENP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (63)

Target	Relation	Type	Str
MANF	de-SUMOylates	protein	0.90
MANF	modulates	protein	0.85
MANF	modifies	protein	0.80
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	inhibits	disease	0.65
Leukemia	activates	disease	0.65
Tumor	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	activates	disease	0.65
Apoptosis	activates	pathway	0.60
CANCER	activates	gene	0.60
Chemoresistance	activates	pathway	0.60
Mtor	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Ras	activates	protein	0.60
SUMO1	activates	gene	0.60
YME1L1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	activates	gene	0.60
Igf	activates	protein	0.60
AND	activates	gene	0.60
Egfr	activates	protein	0.60
MITOPHAGY	regulates	gene	0.60
CANCER	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
PARKIN	regulates	gene	0.60
RNA	expressed_in	gene	0.60
Differentiation	activates	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
MITOCHONDRIA	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
PRKN	regulates	gene	0.60
MANF	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
NRF1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HIF1A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
IGF2BP3	activates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
PIN1	binds	protein	0.80
APOPTOSIS	regulates	gene	0.60
RNA	expressed_in	gene	0.60
SIRT3	activates	gene	0.60
OPA1	activates	gene	0.60
AMPK	activates	gene	0.60
IGF2BP3	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	activates	gene	0.60
MTOR	regulates	gene	0.60
AKT	regulates	gene	0.60
HDAC2	interacts_with	gene	0.60
MFN1	inhibits	gene	0.60
HDAC2	activates	gene	0.60
VHL	activates	gene	0.60
mTOR	regulates	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Surface Exposure of SENP1-β1 Integrin Complex Enables Target	0.550	neurodegeneration	How can senescent microglia be molecular

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SENP1 in their description or question text

No additional research found