gene 614 words KG: NRF1
Contents

NRF1 Gene

🧬 Gene Info
Gene SymbolNRF1
Chromosome5q31.1
Protein TypeGene
FunctionNRF1 is a critical transcription factor that coordinates the expression of genes involved in mitochondrial function and cellular respiration: [@srensen2020]
Primary Expressiontissues with high energy demands:
PathwaysApoptosis, Autophagy, Chaperone, Cholesterol, Differentiation
GeneCardsNRF1
Human Protein AtlasNRF1
Associated DiseasesAging, Als, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compoundsnicotinamide, rapamycin
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AMYLOID-BETA
KG Connections490 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (21)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69

Related Analyses (13)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Sirtuin Pathway Dysfunction Validation in Parkinson's Diseas
clinical · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40

See Also (15)

Cell-Free DNA Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 9 hypotheses
Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 9 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses

Knowledge Graph (12 edges)

PGC1A activates NRF1
NRF1 activates TFAM
NRF1 therapeutic_target PPARGC1A
NRF1 therapeutic_target SIRT1
NRF1 therapeutic_target DNM1L
NRF1 activates DRP1
NRF1 therapeutic_target PRKAA1
NRF1 therapeutic_target JUN
NRF1 activates OPA1
NRF1 activates MFN1

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