protein

NFE2L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFE2L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

46Outgoing

20Incoming

0Experiments

0Debates

Summary

NFE2L1 is a protein involved in neurodegeneration research. Key relationships include: implicated in, expressed in, regulates. Associated with Aging, Als, Alzheimer. Connected to 18 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NFE2L1
Full Name	Nuclear Factor Erythroid 2 Like 1
Chromosome	7q11.23
Protein Type	Transcription Factor
Function	NFE2L1 encodes Nrf1 (Nuclear factor erythroid 2-related factor 1), a transcription factor that regulates antioxidant response and proteasome expression.
Primary Expression	both neurons and glial cells, where it plays essential roles in maintaining redox balance, regulating proteasome function, and coordinating cellular s
Subcellular Localization	</strong></td><td>Endoplasmic Reticulum (anchored), Nucleus (active form)</td></tr>
Molecular Weight	90 kDa
Amino Acids	742 aa
Pathways	Proteasome Subunit Genes
UniProt ID	[Q14145](https://www.uniprot.org/uniprot/Q14145)
Ensembl ID	ENSG00000118307
OMIM	130120
GeneCards	NFE2L1
Human Protein Atlas	NFE2L1
Associated Diseases	Aging, Als, Alzheimer, Neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, App, GENES
KG Connections	66 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NFE2L1["NFE2L1"]
    Proteasome_Subunit_Genes(["Proteasome Subunit Genes"])
    NFE2L1 -->|"regulates"| Proteasome_Subunit_Genes
    Aging{"Aging"}
    NFE2L1 -->|"implicated in"| Aging
    Als{"Als"}
    NFE2L1 -->|"implicated in"| Als
    Neurodegeneration{"Neurodegeneration"}
    NFE2L1 -->|"implicated in"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    NFE2L1 -->|"implicated in"| Alzheimer
    P62["P62"]
    NFE2L1 -->|"implicated in"| P62
    NRF1["NRF1"]
    NFE2L1 -->|"expressed in"| NRF1
    AMYLOID["AMYLOID"]
    NFE2L1 -->|"implicated in"| AMYLOID
    GENES["GENES"]
    NFE2L1 -->|"regulates"| GENES
    AMYLOID_BETA["AMYLOID-BETA"]
    NFE2L1 -->|"implicated in"| AMYLOID_BETA
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    NFE2L1 -->|"implicated in"| ALZHEIMER_S_DISEASE
    UBIQUITIN["UBIQUITIN"]
    NFE2L1 -->|"implicated in"| UBIQUITIN
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"implicated in"| NFE2L1
    TAU["TAU"]
    TAU -->|"implicated in"| NFE2L1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"implicated in"| NFE2L1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"implicated in"| NFE2L1
    style NFE2L1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

Target	Relation	Type	Str
Proteasome Subunits	upregulates	protein	0.85
Proteasome Subunit Genes	regulates	pathway	0.85
Aging	implicated_in	disease	0.65
Aging	degrades	disease	0.65
Neurodegeneration	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Als	degrades	disease	0.65
Als	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Alzheimer	implicated_in	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
Ubiquitin-Proteasome	inhibits	pathway	0.60
Amyloid	inhibits	pathway	0.60
App	inhibits	protein	0.60
RNA	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Amyloid-Beta	degrades	protein	0.60
AMYLOID	implicated_in	gene	0.60
GENES	regulates	gene	0.60
AMYLOID-BETA	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
Ubiquitin-Proteasome	implicated_in	pathway	0.60
Proteasome	expressed_in	pathway	0.60
Neuron	inhibits	cell_type	0.60
Ubiquitin-Proteasome	degrades	pathway	0.60
Neuron	degrades	cell_type	0.60
Α-Synuclein	degrades	protein	0.60
NRF1	regulates	entity	0.60
SQSTM1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
P62	inhibits	gene	0.60
TAU	inhibits	gene	0.60
P62	implicated_in	gene	0.60
NRF1	expressed_in	gene	0.60
UBIQUITIN	implicated_in	gene	0.60
Neuron	expressed_in	cell_type	0.55
NRF1	activates	gene	0.50

Incoming (20)

Source	Relation	Type	Str
TAU	implicated_in	gene	0.60
SQSTM1	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
ALZHEIMER	implicated_in	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ALZHEIMER	degrades	gene	0.60
AMYLOID-BETA	degrades	gene	0.60
TAU	degrades	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
NRF1	expressed_in	gene	0.60
NRF1	interacts_with	gene	0.50
NRF1	activates	gene	0.50
NEURON	co_discussed	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
GENES	activates	gene	0.50
P62	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NFE2L1 in their description or question text

No additional research found