gene

PSMB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

17Outgoing

0Incoming

0Experiments

0Debates

Summary

PSMB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, degrades. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PSMB1
Full Name	Proteasome Subunit Beta 1
Chromosome	6q27
Function	encodes the beta1 subunit of the 20S proteasome, also known as the epsilon subunit or LMP7-related protein
Primary Expression	all major neuronal subtypes - Glial cells: Present in astrocytes, microglia, an
Molecular Weight	26.4 kDa
Amino Acids	22 aa
Pathways	WNT
UniProt ID	P20618
NCBI Gene ID	5689
Ensembl ID	ENSG00000100578
OMIM	176848
GeneCards	PSMB1
Human Protein Atlas	PSMB1
Associated Diseases	neurodegeneration
Interactions	NBR1, RGN, UPK1A
KG Connections	17 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PSMB1 — AlphaFold P20618 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSMB1["PSMB1"]
    PSMA4["PSMA4"]
    PSMB1 -->|"associated with"| PSMA4
    PSMD10["PSMD10"]
    PSMB1 -->|"associated with"| PSMD10
    PSMD6["PSMD6"]
    PSMB1 -->|"associated with"| PSMD6
    PSMD9["PSMD9"]
    PSMB1 -->|"associated with"| PSMD9
    PSMD13["PSMD13"]
    PSMB1 -->|"associated with"| PSMD13
    PSMB3["PSMB3"]
    PSMB1 -->|"associated with"| PSMB3
    PSMC1["PSMC1"]
    PSMB1 -->|"associated with"| PSMC1
    PSMC2["PSMC2"]
    PSMB1 -->|"associated with"| PSMC2
    PSMD7["PSMD7"]
    PSMB1 -->|"associated with"| PSMD7
    PSMD14["PSMD14"]
    PSMB1 -->|"associated with"| PSMD14
    AXIN["AXIN"]
    PSMB1 -->|"regulates"| AXIN
    RAB34["RAB34"]
    PSMB1 -->|"degrades"| RAB34
    style PSMB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
UPK1A	interacts_with	protein	0.80
AXIN	regulates	protein	0.80
PSMD14	associated_with	gene	0.80
PSMA4	associated_with	gene	0.80
PSMD10	associated_with	gene	0.80
PSMD6	associated_with	gene	0.80
PSMD9	associated_with	gene	0.80
PSMD13	associated_with	gene	0.80
PSMB3	associated_with	gene	0.80
PSMC1	associated_with	gene	0.80
PSMC2	associated_with	gene	0.80
PSMD7	associated_with	gene	0.80
RAB34	degrades	protein	0.80
NBR1	interacts_with	protein	0.80
IKK-ε	degrades	protein	0.80
RGN	interacts_with	protein	0.80
WNT	activates	pathway	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSMB1 in their description or question text

No additional research found