Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about lipid droplet: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LD |
| Full Name | Lipid Droplet (organelle) |
| Aliases | Lipid body, Adiposome |
| Protein Type | Cellular organelle |
| Function | Ubiquitous organelle storing neutral lipids (triglycerides, cholesterol esters). In neurons and glia, dysregulated lipid droplet metabolism is linked to neurodegeneration via lipotoxicity and impai... |
| Pathways | Lipid metabolism, APOE lipid transport, Perilipin signaling, Lipophagy |
| GeneCards | LD |
| Human Protein Atlas | LD |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS, Niemann-Pick disease |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
graph TD
lipid_droplet["lipid droplet"] -->|"involved in"| lipid_metabolism["lipid metabolism"]
style lipid_metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -->|"found in"| neurons["neurons"]
style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -->|"involved in"| unfolded_protein_response["unfolded protein response"]
style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -->|"found in"| microglia["microglia"]
style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -.->|"inhibits"| phagocytosis["phagocytosis"]
style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -->|"involved in"| cellular_metabolism["cellular metabolism"]
style cellular_metabolism fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
lipid_droplet["lipid droplet"] -->|"promotes"| INFLAMMATION["INFLAMMATION"]
style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
DGAT1["DGAT1"] -->|"involved in"| lipid_droplet["lipid droplet"]
style DGAT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
DGAT2["DGAT2"] -->|"involved in"| lipid_droplet["lipid droplet"]
style DGAT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
FIT2["FIT2"] -->|"regulates"| lipid_droplet["lipid droplet"]
style FIT2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"disrupts"| lipid_droplet["lipid droplet"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"disrupts"| lipid_droplet["lipid droplet"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style lipid_droplet fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Lipid Storage | mediates | process | 0.88 |
| cellular metabolism | involved_in | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE4 astrocytes exhibit impaired cholesterol efflux via ABC | 0.760 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| Metabolic Circuit Breaker via Lipid Droplet Modulation | 0.709 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| TREM2 R47H variant synergizes with APOE4 to collapse microgl | 0.670 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| Lipid Droplet Dynamics as Phenotype Switches | 0.666 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| APOE4 drives astrocyte metabolic reprogramming toward glycol | 0.580 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| Structure-interacting small molecules that stabilize the APO | 0.580 | neuroscience | APOE4-driven lipid metabolism dysregulat |
| PLIN2 (Perilipin-2) Degradation via Autophagy Activation to | 0.535 | lipidomics | Lipid metabolism dysregulation in Alzhei |
| Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet | 0.515 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
lipidomics | 2026-04-16 | 7 hypotheses Top: 0.725
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Metabolic Pathway-Targeted Therapy in ALS | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Cytochrome Therapeutics | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria [PMID:38773347] | Meng Y, Guo D, Lin L, Zhao H, Xu W, Luo | Nat Metab | 2024 | 1 |
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Lipid accumulation drives cellular senescence in dopaminergic neurons. [PMID:39033779] | Russo T, Riessland M | Aging (Albany NY) | 2024 | 1 |
| Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regu [PMID:37494933] | Roberts MA, Deol KK, Mathiowetz AJ, Lang | Dev Cell | 2023 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| Comprehensive single-cell transcriptional profiling defines shared and unique ep [PMID:36265491] | Li H, Dixon EE, Wu H, Humphreys BD | Cell Metab | 2022 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration a [PMID:41546868] | ["Tabor G", "Litvinchuk A", "Chen Y", "A | Cell reports | 2026 | 0 |
| Novel mechanisms of dietary folic acid in improving hepatopancreas health of gra [PMID:41871815] | Wang Y, Feng L, Dan Jiang W, Wu P, Liu Y | The Journal of nutritional bio | 2026 | 0 |
| African swine fever virus hijacks lipolysis induced by chaperone-mediated autoph [PMID:41801037] | ["Yang X", "Xiong X", "Liu H", "Wen X", | mBio | 2026 | 0 |
| Carotid plaque macrophage burden and inflammatory lipid-associated macrophage ma [PMID:41758068] | ["Prange K", "Bel-Bordes G", "Depuydt M" | European heart journal | 2026 | 0 |
| Lipophagy fuels phosphatidylcholine synthesis for Newcastle disease virus replic [PMID:41810751] | ["Yang M", "Chen J", "Su X", "Kan X", "T | Autophagy | 2026 | 0 |
| Epithelial-Mesenchymal Transition Shapes the Lipotoxic Response of Colon Cancer [PMID:41831570] | Vari F, Serra I, Bisconti E, Stanca E, R | Molecular & cellular proteomic | 2026 | 0 |
| Serum Perilipin-2 as a Novel Biomarker for Obstructive Sleep Apnea: Association [PMID:41827192] | Sagcan G, Uzun H | Journal of clinical medicine | 2026 | 0 |
| PCDHGC3 silencing promotes clear cell renal cell carcinoma metastasis via mTOR/H [PMID:41888110] | Celada L, Cubiella T, San-Juan-Guardado | Cell death & disease | 2026 | 0 |
| Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations [PMID:41897862] | Wang B, Li Y, Wang Y, Chen J, Wang J et | Animals (Basel) | 2026 | 0 |
| Integrated Analysis of Metabolomics and Proteomics Reveals the Potential Mechani [PMID:41841177] | ["Wu S", "Wang B", "Zhang N", "Feng C", | Journal of applied toxicology | 2026 | 0 |
| Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284] | Xie XY, Wang L, Xie SQ, Zhou GF, Wen QX, | Autophagy | 2026 | 0 |
| Analysis of high glucose injury using human induced pluripotent stem cell-derive [PMID:41507800] | ["Qian Z", "Yang D", "Li Y", "Dong R", " | BMC nephrology | 2026 | 0 |
| Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-C [PMID:41795330] | ["Dohnalov\u00e1 K", "Kamaraj R", "Ambro | Biomedicine & pharmacotherapy | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning lipid droplet in their description or question text
Score: 0.580 · neuroscience · 2026-04-22
## Mechanistic Overview Structure-interacting small molecules that stabilize the APOE4 molten globule domain (Domain III
Score: 0.535 · lipidomics · 2026-04-25
PLIN2 (Perilipin-2) Degradation via Autophagy Activation to Clear Disease-Associated Lipid Droplets
Score: 0.515 · lipidomics · 2026-04-25
Astrocyte-Specific DGAT1 Inhibition to Prevent Lipid Droplet-Induced Neuroinflammation