gene 778 words KG: NBR1
Contents

NBR1 Gene

🧬 Gene Info
Gene SymbolNBR1
Full NameNeighbor of BRCA1 Gene 1
Chromosome17q21.31
Protein TypeReceptor
FunctionNBR1 is a selective autophagy receptor
Primary Expressionall brain cell types:
PathwaysAkt, Autophagy, Chaperone, Innate Immunity, Lysosomal Degradation
UniProt IDQ14596
NCBI Gene ID10327
Ensembl IDENSG00000132716
OMIM605085
GeneCardsNBR1
Human Protein AtlasNBR1
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compoundsdimethyl fumarate, rapamycin
InteractionsABCD3, ABP, ACAT1, ACTB, Actin, Akt
KG Connections1419 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (13)

Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Phase-Separated Organelle Targeting
Score: 0.73

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (10)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABI3 Gene
gene · KG edge: regulates
ACTB Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ACTB interacts_with NBR1
OPTN interacts_with NBR1
ULK1 interacts_with NBR1
SMCR8 interacts_with NBR1
CALCOCO2 interacts_with NBR1
LC3 interacts_with NBR1
BECN1 interacts_with NBR1
C9ORF72 interacts_with NBR1
NBR1 interacts_with G3BP1
NBR1 interacts_with TOLLIP

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