concept

INTERFERON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERFERON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

556Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	INTERFERON
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

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Pathway Diagram

graph TD
    INTERFERON["INTERFERON"]
    style INTERFERON fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERFERON -->|"interacts"| Dementia["Dementia"]
    INTERFERON -->|"interacts"| Alzheimer["Alzheimer"]
    INTERFERON -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    INTERFERON -->|"interacts"| Parkinson["Parkinson"]
    INTERFERON -->|"interacts"| Als["Als"]
    INTERFERON -->|"activates"| Aging["Aging"]
    INTERFERON -->|"interacts"| Fibrosis["Fibrosis"]
    INTERFERON -->|"interacts"| Cancer["Cancer"]
    INTERFERON -->|"activates"| Ferroptosis["Ferroptosis"]
    NBR1([NBR1]) -.->|"inhibits"| INTERFERON
    p62([p62]) -->|"activates"| INTERFERON
    STING["STING"] -->|"upregulates"| INTERFERON
    HNRNPA1([HNRNPA1]) -->|"upregulates"| INTERFERON
    STING1([STING1]) -->|"activates"| INTERFERON
    DISC1([DISC1]) -->|"interacts"| INTERFERON
    GBA([GBA]) -->|"interacts"| INTERFERON
    TAX1BP1([TAX1BP1]) -->|"interacts"| INTERFERON
    ROS([ROS]) -->|"interacts"| INTERFERON
    ALS([ALS]) -->|"interacts"| INTERFERON

Outgoing (146)

Target	Relation	Type	Str
ZBP1	upregulates	protein	0.85
Aging	therapeutic_target	disease	0.60
Diabetes	activates	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Parkinson	activates	disease	0.60
Multiple Sclerosis	degrades	disease	0.60
Fibrosis	interacts_with	disease	0.60
Aging	expressed_in	disease	0.60
Lymphoma	activates	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Neuroinflammation	activates	disease	0.60
Ferroptosis	degrades	disease	0.60
Parkinson	interacts_with	disease	0.60
Cancer	interacts_with	disease	0.60
Multiple Sclerosis	activates	disease	0.60
Als	therapeutic_target	disease	0.60
Atherosclerosis	activates	disease	0.60
Cancer	activates	disease	0.60
Aging	activates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Als	associated_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Dementia	interacts_with	disease	0.60
Addiction	therapeutic_target	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurodegeneration	degrades	disease	0.60
Als	expressed_in	disease	0.60
Hypertension	activates	disease	0.60
Obesity	activates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Alzheimer	interacts_with	disease	0.60
Als	regulates	disease	0.60
Cancer	associated_with	disease	0.60
Als	interacts_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Encephalitis	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Stroke	interacts_with	disease	0.60
Als	inhibits	disease	0.60
Ferroptosis	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Neurodegeneration	activates	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60

Incoming (410)

Source	Relation	Type	Str
STING	upregulates	entity	0.90
p62	activates	protein	0.90
NBR1	inhibits	protein	0.90
HNRNPA1	upregulates	protein	0.85
STING1	activates	protein	0.70
IL-1	activates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
PYROPTOSIS	regulates	gene	0.60
FUS	activates	gene	0.60
P38	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
P2RX7	expressed_in	gene	0.60
TAUOPATHY	activates	gene	0.60
DEPRESSION	activates	gene	0.60
C4B	activates	gene	0.60
RNA	encodes	gene	0.60
IRF8	regulates	gene	0.60
AKT	regulates	gene	0.60
IL10	activates	gene	0.60
SPI1	activates	gene	0.60
IL8	activates	gene	0.60
CCL5	regulates	gene	0.60
CD163	activates	gene	0.60
TAK1	associated_with	gene	0.60
TIRAP	associated_with	gene	0.60
PAK1	associated_with	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MYD88	associated_with	gene	0.60
ERK1/2	associated_with	gene	0.60
NEK7	associated_with	gene	0.60
JNK	associated_with	gene	0.60
TRAF6	associated_with	gene	0.60
LIMK1	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
ASC	associated_with	gene	0.60
TCR	associated_with	gene	0.60
GSDMD	associated_with	gene	0.60
TNF	associated_with	gene	0.60
C1Q	activates	gene	0.60
STING1	activates	gene	0.60
CREB	associated_with	gene	0.60
NLRP6	activates	gene	0.60
IFN	regulates	gene	0.60
HDAC	activates	gene	0.60
NF-KB	activates	gene	0.60
MICROGLIA	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
HDAC3	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERFERON in their description or question text

No additional research found