concept

INTERFERON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERFERON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

556Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	INTERFERON
Key Genes/Proteins	ABCD3, ACTIN, ALZHEIMER DISEASE, AMBRA1, AMPK, ATG
Related Diseases	ALS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

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Pathway Diagram

graph TD
    INTERFERON["INTERFERON"]
    style INTERFERON fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERFERON -->|"interacts"| Dementia["Dementia"]
    INTERFERON -->|"interacts"| Alzheimer["Alzheimer"]
    INTERFERON -->|"interacts"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    INTERFERON -->|"interacts"| Parkinson["Parkinson"]
    INTERFERON -->|"interacts"| Als["Als"]
    INTERFERON -->|"activates"| Aging["Aging"]
    INTERFERON -->|"interacts"| Fibrosis["Fibrosis"]
    INTERFERON -->|"interacts"| Cancer["Cancer"]
    INTERFERON -->|"activates"| Ferroptosis["Ferroptosis"]
    NBR1([NBR1]) -.->|"inhibits"| INTERFERON
    p62([p62]) -->|"activates"| INTERFERON
    STING["STING"] -->|"upregulates"| INTERFERON
    HNRNPA1([HNRNPA1]) -->|"upregulates"| INTERFERON
    STING1([STING1]) -->|"activates"| INTERFERON
    DISC1([DISC1]) -->|"interacts"| INTERFERON
    GBA([GBA]) -->|"interacts"| INTERFERON
    TAX1BP1([TAX1BP1]) -->|"interacts"| INTERFERON
    ROS([ROS]) -->|"interacts"| INTERFERON
    ALS([ALS]) -->|"interacts"| INTERFERON

Outgoing (146)

Target	Relation	Type	Str
ZBP1	upregulates	protein	0.85
Cancer	interacts_with	disease	0.60
Fibrosis	interacts_with	disease	0.60
Als	inhibits	disease	0.60
Atherosclerosis	activates	disease	0.60
Lymphoma	activates	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Stroke	regulates	disease	0.60
Dementia	activates	disease	0.60
Alzheimer	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Neuroinflammation	protects_against	disease	0.60
Pyroptosis	activates	disease	0.60
Necroptosis	activates	disease	0.60
Neuroinflammation	causes	disease	0.60
Alzheimer	causes	disease	0.60
Spinal Cord Injury	activates	disease	0.60
Tauopathy	activates	disease	0.60
Stroke	activates	disease	0.60
Epilepsy	activates	disease	0.60
Multiple Sclerosis	expressed_in	disease	0.60
Pyroptosis	regulates	disease	0.60
Ferroptosis	activates	disease	0.60
Als	activates	disease	0.60
Stroke	interacts_with	disease	0.60
Dementia	interacts_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Frontotemporal Dementia	interacts_with	disease	0.60
Parkinson	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Als	associated_with	disease	0.60
Cancer	activates	disease	0.60
Neurodegeneration	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Als	regulates	disease	0.60
Alzheimer	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Encephalitis	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	expressed_in	disease	0.60
Als	expressed_in	disease	0.60
Ferroptosis	inhibits	disease	0.60

Incoming (410)

Source	Relation	Type	Str
STING	upregulates	entity	0.90
NBR1	inhibits	protein	0.90
p62	activates	protein	0.90
HNRNPA1	upregulates	protein	0.85
STING1	activates	protein	0.70
TAX1BP1	interacts_with	gene	0.60
SLC7A11	associated_with	gene	0.60
ALS	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
IFN	associated_with	gene	0.60
BCL2L13	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
STING	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
TDP-43	associated_with	gene	0.60
ALS	associated_with	gene	0.60
DNA	activates	gene	0.60
MTDNA	activates	gene	0.60
CGAS	activates	gene	0.60
MTDNA	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
POLG	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ALOX	associated_with	gene	0.60
ATM	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
ROS	interacts_with	gene	0.60
FANCD2	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
ROS	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
STING	inhibits	gene	0.60
CD68	activates	gene	0.60
RNA	activates	gene	0.60
ANXA1	inhibits	gene	0.60
CGAS-STING	inhibits	gene	0.60
IFN	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
EZH2	activates	gene	0.60
IRF3	activates	gene	0.60
IFN	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Chronic cGAS/STING Hyperactivation Drives Progressive Neurod	0.661	neuroinflammation	How does chronic cGAS/STING activation d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERFERON in their description or question text

No additional research found