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protein 570 words KG: MFN2
Contents

Mitofusin 2 (MFN2)

🔬 Protein Info
Gene SymbolMFN2
AliasesMitofusin 2
Chromosome1p36.22
FunctionTrans-tethering: HR2 domains form antiparallel complexes between adjacent mitochondria
Subcellular Localizationthe outer mitochondrial membrane that functions as a critical regulator of mitochondrial dynamics and inter-organellar c
Molecular Weight84 kDa
Amino Acids757 aa
Exons17
PathwaysNF-κB, AMPK
GeneCardsMFN2
Human Protein AtlasMFN2
Associated Diseasesaging, Als, CHARCOT-MARIE-TOOTH, Charcot-Marie-Tooth Type 2A, Fibrosis, Hereditary Polyneuropathy
Known Drugs/Compounds8015-P2, Piperine
InteractionsABCG2, AGING, AKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections720 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (26)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88APOE-Dependent Autophagy Restoration
Score: 0.85Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Extracellular Matrix Stiffness Modulation
Score: 0.69CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69R-Loop Resolution Enhancement Therapy
Score: 0.68Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62Digital Twin-Guided Metabolic Reprogramming
Score: 0.55PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
pg 1/2Next →

Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedDigital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived

See Also (5)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: activatesABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesAKT1 Gene
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: inhibits

Knowledge Graph (12 edges)

OPA1 regulates MFN2
MFN2 regulates MTOR
BAX activates MFN2
DRP1 activates MFN2
FADD activates MFN2
NRF2 activates MFN2
ABCG2 activates MFN2
ZBP1 activates MFN2
MFN2 activates GSDMD
MFN2 activates RIPK1

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