protein

PGC-1Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGC-1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections

3Hypotheses

3Analyses

50Outgoing

34Incoming

2Experiments

3Debates

Summary

Page for PGC-1α Protein

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🔬 Protein Info

Gene Symbol	PGC
Full Name	1α Protein
Function	Pgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	PGC
Human Protein Atlas	PGC
PPARGC1A gene	Encoding locus for PGC-1α
NRF1/NRF2	Nuclear respiratory
Associated Diseases	Neurodegenerative Diseases
Interactions	ALZHEIMER, AMPK, HSP90, LAMP2, LAMP2A, MEF2C
KG Connections	81 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PGC-1α Protein

redirect · 629 words

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Pathway Diagram

graph TD
    PGC_1_["PGC-1Alpha"]
    TUG_CLEAVAGE_PRODUCT["TUG CLEAVAGE PRODUCT"]
    TUG_CLEAVAGE_PRODUCT -->|"interacts with"| PGC_1_
    PPAR["PPAR"]
    PGC_1_ -->|"activates"| PPAR
    GLUT4["GLUT4"]
    PGC_1_ -->|"activates"| GLUT4
    GENE_EXPRESSION["GENE EXPRESSION"]
    PGC_1_ -->|"activates"| GENE_EXPRESSION
    NUCLEUS["NUCLEUS"]
    PGC_1_ -->|"activates"| NUCLEUS
    PEROXISOME["PEROXISOME"]
    PGC_1_ -->|"activates"| PEROXISOME
    NEURONS["NEURONS"]
    PGC_1_ -->|"activates"| NEURONS
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"activates"| INTERNEURONS
    NEURONS["NEURONS"]
    PGC_1_ -->|"protects against"| NEURONS
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"protects against"| INTERNEURONS
    NEURONS["NEURONS"]
    PGC_1_ -->|"interacts with"| NEURONS
    Differentiation["Differentiation"]
    PGC_1_ -->|"interacts with"| Differentiation
    GENE_EXPRESSION["GENE EXPRESSION"]
    PGC_1_ -->|"interacts with"| GENE_EXPRESSION
    INTERNEURONS["INTERNEURONS"]
    PGC_1_ -->|"interacts with"| INTERNEURONS
    PPAR__["PPAR-Gamma"]
    PGC_1_ -->|"activates"| PPAR__
    Neuroprotection["Neuroprotection"]
    PGC_1_ -->|"activates"| Neuroprotection
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    PGC_1_ -->|"activates"| MITOCHONDRIAL_DNA
    Proteins["Proteins"]
    PGC_1_ -->|"activates"| Proteins
    cancer["cancer"]
    PGC_1_ -->|"activates"| cancer
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    PGC_1_ -->|"activates"| OXIDATIVE_PHOSPHORYLATION
    METASTASIS["METASTASIS"]
    PGC_1_ -->|"activates"| METASTASIS
    cancer["cancer"]
    PGC_1_ -->|"expressed in"| cancer
    cancer["cancer"]
    PGC_1_ -->|"inhibits"| cancer
    METASTASIS["METASTASIS"]
    PGC_1_ -->|"inhibits"| METASTASIS
    Invasion["Invasion"]
    PGC_1_ -->|"activates"| Invasion
    ALZHEIMER["ALZHEIMER"]
    PGC_1_ -->|"activates"| ALZHEIMER
    mitophagy["mitophagy"]
    PGC_1_ -->|"activates"| mitophagy
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    PGC_1_ -->|"activates"| Alzheimer_S_Disease
    AMPK["AMPK"]
    PGC_1_ -->|"activates"| AMPK
    disease["disease"]
    PGC_1_ -->|"activates"| disease

Outgoing (71)

Target	Relation	Type	Str
mitochondrial biogenesis	promotes	process	0.95
Mitochondrial Biogenesis	promotes	process	0.90
mitochondrial biogenesis	regulates	process	0.90
Pv+ Interneurons	regulates	cell_type	0.90
oxidative_metabolism	activates	pathway	0.90
Mitochondrial Function	regulates	process	0.85
Structural, Electrophysiological, Synaptic, And Metabolic Features	regulates	phenotype	0.80
Schwann cells	expressed_in	cell_type	0.70
Nrf2	interacts_with	protein	0.70
SIRT3	activates	protein	0.70
MFN2	regulates	protein	0.70
ULK1	activates	protein	0.70
mitophagy	activates	process	0.70
mitochondrial biogenesis	regulates	process	0.70
neuroinflammation	inhibits	process	0.70
NLRP3	inhibits	protein	0.70
Alzheimer's disease	protects_against	disease	0.60
cancer	inhibits	disease	0.50
Invasion	activates	pathway	0.50
ALZHEIMER	activates	gene	0.50
mitophagy	activates	pathway	0.50
cancer	activates	disease	0.50
AMPK	activates	protein	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
Alzheimer'S Disease	activates	disease	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
cancer	expressed_in	disease	0.50
GENE EXPRESSION	activates	concept	0.50
NUCLEUS	activates	concept	0.50
PEROXISOME	activates	concept	0.50
NEURONS	activates	concept	0.50
INTERNEURONS	activates	concept	0.50
NEURONS	interacts_with	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
INTERNEURONS	interacts_with	concept	0.50
PPAR-Γ	activates	concept	0.50
Neuroprotection	activates	process	0.50
MITOCHONDRIAL DNA	activates	gene	0.50
Proteins	activates	protein	0.50
EXERCISE	activates	concept	0.50
RAPAMYCIN	inhibits	concept	0.50
UBIQUITIN	regulates	protein	0.50
Ubiquitin-Proteasome	regulates	pathway	0.50
Chaperone	regulates	pathway	0.50
FBXW7	regulates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	regulates	concept	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50

Incoming (34)

Source	Relation	Type	Str
SIRT1	activates	protein	0.90
TUG CLEAVAGE PRODUCT	interacts_with	entity	0.90
AMPK	activates	protein	0.85
Neural Activity	activates	process	0.80
PM10	downregulates	compound	0.80
PPARGC1A	encodes	gene	0.70
SIRT1 activation	activates	protein	0.70
PPAR-γ	interacts_with	protein	0.70
Copper	inhibits	drug	0.70
AMPK	regulates	protein	0.70
FBXW7	inhibits	protein	0.60
SIRT3	activates	gene	0.50
Neurodegeneration	associated_with	disease	0.50
PPARGC1A	activates	gene	0.50
TFAM	inhibits	gene	0.50
mTOR	inhibits	entity	0.50
NRF1	inhibits	gene	0.50
MEF2C	inhibits	gene	0.50
Autophagy	regulates	process	0.50
Autophagy	activates	process	0.50
LAMP2A	activates	gene	0.50
LAMP2	activates	protein	0.50
SIRT1	deacetylation	gene	0.50
NEURON	co_discussed	gene	0.50
PGC-1	co_discussed	protein	0.50
MEF2C	co_discussed	gene	0.50
MEF2C	interacts_with	gene	0.50
TFAM	activates	gene	0.50
NRF1	activates	gene	0.50
NRF2	activates	gene	0.50
MITOCHONDRIA	activates	cell_type	0.50
HSP90	activates	protein	0.50
MITOCHONDRIA	inhibits	cell_type	0.50
MITOCHONDRIA	regulates	cell_type	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resil	0.778	neurodegeneration	Gut Microbiome Analysis in Parkinson's D
APOE4 drives astrocyte metabolic reprogramming toward glycol	0.580	neuroscience	APOE4-driven lipid metabolism dysregulat
HBOT at 2.0 ATA for 60 minutes restores PGC-1α-mediated mito	0.520	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (3)

Scientific analyses that reference this entity

Comparative epigenetic signatures across AD, PD, and ALS

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.550

test debate

neurodegeneration | 2026-04-15 | 0 hypotheses

What neural circuits encode and maintain multi-generational migratory route memo

spatial memory | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PGC-1α knockout analysis of PV+ interneuron maturation	validation	neurodevelopmental disorders	0.850	0.00	knockout mice	proposed	N/A
PV+ interneuron subtype diversification analysis	exploratory	neurodevelopmental disorders	0.750	0.00	mouse cortical PV+ interneuron	proposed	N/A

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (3)

Multi-agent debates referencing this entity

What are the shared DNA methylation age acceleration and histone modification pa

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

test debate [TARGET_ARTIFACT type=experiment id=exp-123]

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

The paper describes memory-based migration routes maintained across generations

closed · Rounds: 4 · Score: 0.95 · 2026-04-09

Related Research

Hypotheses and analyses mentioning PGC-1Α in their description or question text

No additional research found