concept

MAPK SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

615Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MAPK SIGNALING
Key Genes/Proteins	AKT, AKT1, AMPK, APP, CASP3
Related Diseases	AUTISM, cancer, CANCER, Cardiac
Related Pathways	Camp Signaling

Pathway Diagram

graph TD
    MAPK_SIGNALING["MAPK SIGNALING"]
    MAPK_SIGNALING -->|"regulates"| Hepatocyte_Apoptosis["Hepatocyte Apoptosis"]
    MAPK_SIGNALING -->|"activates"| P38["P38"]
    MAPK_SIGNALING -->|"regulates"| PI3K["PI3K"]
    MAPK_SIGNALING -->|"inhibits"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    MAPK_SIGNALING -->|"activates"| NF_KB["NF-KB"]
    KDEL["KDEL"] -->|"regulates"| MAPK_SIGNALING
    Paeoniflorin["Paeoniflorin"] -->|"modulates"| MAPK_SIGNALING
    ARHGEF2["ARHGEF2"] -->|"activates"| MAPK_SIGNALING
    ATOX1["ATOX1"] -->|"activates"| MAPK_SIGNALING
    lithium["lithium"] -->|"activates"| MAPK_SIGNALING
    AKT["AKT"] -->|"regulates"| MAPK_SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"activates"| MAPK_SIGNALING
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| MAPK_SIGNALING

Outgoing (63)

Target	Relation	Type	Str
NF-kB signaling	crosstalk_with	pathway	0.90
neural stem cells	active_in	cell_type	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
Hepatocyte Apoptosis	regulates	process	0.89
Prostate Cancer Progression	contributes_to	process	0.85
microglia	active_in	cell_type	0.80
neurons	active_in	cell_type	0.80
unfolded protein response	crosstalk_with	pathway	0.70
pyroptosis	mediates	process	0.70
astrocytes	active_in	cell_type	0.70
P38	activates	gene	0.65
dendritic cells	active_in	cell_type	0.60
autophagy pathway	crosstalk_with	pathway	0.60
necroptosis	crosstalk_with	pathway	0.60
ER stress	mediates	process	0.60
protein misfolding	mediates	process	0.60
ferroptosis	mediates	process	0.60
tau phosphorylation	mediates	process	0.60
pyroptosis	crosstalk_with	pathway	0.60
spinal cord	active_in	brain_region	0.60
calcium signaling	mediates	process	0.60
nucleus accumbens	active_in	brain_region	0.60
white matter	active_in	brain_region	0.60
calcium signaling	crosstalk_with	pathway	0.60
cortex	active_in	brain_region	0.60
synaptic plasticity	crosstalk_with	pathway	0.60
endothelial cells	active_in	cell_type	0.60
glymphatic clearance	crosstalk_with	pathway	0.60
ferroptosis	crosstalk_with	pathway	0.60
BERBERINE	activates	concept	0.50
NF-KB	activates	gene	0.50
PI3K	regulates	gene	0.50
NEUROINFLAMMATION	inhibits	process	0.50
NF-KB	inhibits	gene	0.50
RAS	inhibits	gene	0.35
NEURODEGENERATION	activates	process	0.35
PI3K	protects_against	gene	0.35
OXIDATIVE STRESS	activates	process	0.35
TNF	activates	gene	0.35
TOLL-LIKE RECEPTOR SIGNALING	regulates	process	0.35
TNF	regulates	gene	0.35
TLR4	inhibits	gene	0.35
TNF	inhibits	gene	0.35
P38	inhibits	gene	0.35
QUERCETIN	therapeutic_target	drug	0.35
TAU	inhibits	protein	0.35
TAU	activates	protein	0.35
NEURODEGENERATION	biomarker_for	process	0.35
NEUROTOXICITY	biomarker_for	process	0.35
NEUROINFLAMMATION	protects_against	process	0.35

Incoming (552)

Source	Relation	Type	Str
KDEL	regulates	receptor	0.92
Paeoniflorin	modulates	compound	0.91
PI3K	participates_in	gene	0.90
JNK	participates_in	gene	0.90
ERK	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
PI3K-AKT-mTOR Pathway	interacts_with	pathway	0.90
Donepezil	inhibits	drug	0.90
NLRP3	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
neurodegeneration	involves	disease	0.90
lithium	activates	drug	0.80
Alzheimer's disease	involves	disease	0.80
ERK1	participates_in	gene	0.80
TNF	participates_in	gene	0.80
NLR	participates_in	gene	0.80
ERN1	participates_in	gene	0.80
SNCA	participates_in	gene	0.80
AMPK	participates_in	gene	0.80
GSK3B	participates_in	gene	0.80
ATG	participates_in	gene	0.80
AKT	participates_in	gene	0.80
BECN1	participates_in	gene	0.80
ESR1	participates_in	gene	0.80
PIK3CA	participates_in	gene	0.80
MAPK3	participates_in	gene	0.80
ARHGEF2	activates	gene	0.80
GSK3	participates_in	gene	0.80
JAK	participates_in	gene	0.80
MEK	participates_in	gene	0.80
MAP	participates_in	gene	0.80
MAPK14	participates_in	gene	0.80
ATOX1	activates	gene	0.80
ALS	participates_in	gene	0.80
microglia	active_in	cell_type	0.75
neurons	active_in	cell_type	0.75
depression	involves	disease	0.70
NOS3	participates_in	gene	0.70
ANXA5	participates_in	gene	0.70
IGF1	participates_in	gene	0.70
stroke	involves	disease	0.70
LAMP2	participates_in	gene	0.70
AR	participates_in	gene	0.70
HMOX1	participates_in	gene	0.70
JAK1	participates_in	gene	0.70
MAPK10	participates_in	gene	0.70
ATG7	participates_in	gene	0.70
NRBF2	participates_in	gene	0.70
DDIT3	participates_in	gene	0.70
RB1CC1	participates_in	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte CD38-erk Mapk signaling controls mitochondrial tra	0.380	ALS and Alzheimer's disease	Mitochondrial transfer between neurons a

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK SIGNALING in their description or question text

No additional research found