concept

PI3K-AKT-MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT-MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

13Outgoing

3Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K-AKT-MTOR PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_PATHWAY[PI3K-AKT-MTOR PATHWAY]
    PI3K_AKT_MTOR_PATHWAY -->|involved_in| Acute_Myeloid_Leukemia[Acute Myeloid Leukemia]
    PI3K_AKT_MTOR_PATHWAY -->|interacts| AR_Signaling[AR Signaling]
    PI3K_AKT_MTOR_PATHWAY -->|interacts| MAPK_Signaling[MAPK Signaling]
    PI3K_AKT_MTOR_PATHWAY -->|interacts| WNT_Signaling[WNT Signaling]
    PI3K_AKT_MTOR_PATHWAY -->|regulates| Malignant_Cell_Growth[Malignant Cell Growth]
    PI3K_AKT_MTOR_PATHWAY -->|upregulates| Hematopoietic_Stem_Cell_Prolif[Hematopoietic Stem Cell Proliferation]
    PI3K_AKT_MTOR_PATHWAY -->|mediates| Therapeutic_Resistance[Therapeutic Resistance]
    PI3K_AKT_MTOR_PATHWAY -->|mediates| Leukemogenesis[Leukemogenesis]
    PI3K_AKT_MTOR_PATHWAY -->|regulates| AML_Cell_Bioenergetics[AML Cell Bioenergetics]
    PI3K_AKT_MTOR_PATHWAY -->|causes| acute_myeloid_leukemia[acute myeloid leukemia]
    PIK3CA[PIK3CA] -->|activates| PI3K_AKT_MTOR_PATHWAY
    PTEN[PTEN] -->|inhibits| PI3K_AKT_MTOR_PATHWAY

Outgoing (13)

Target	Relation	Type	Str
Acute Myeloid Leukemia	involved_in	disease	0.95
MAPK Signaling	interacts_with	pathway	0.90
WNT Signaling	interacts_with	pathway	0.90
AR Signaling	interacts_with	pathway	0.90
Malignant Cell Growth	regulates	process	0.90
Hematopoietic Stem Cell Proliferation	upregulates	process	0.90
AML Cell Bioenergetics	regulates	phenotype	0.85
Leukemogenesis	mediates	process	0.85
Therapeutic Resistance	mediates	phenotype	0.85
Androgen-Deprivation Therapy	modulates	drug	0.80
acute myeloid leukemia	causes	disease	0.80
AML Prognosis Biomarker	biomarker_for	biomarker	0.75
Alzheimer's disease	activates	disease	0.70

Incoming (3)

Source	Relation	Type	Str
PIK3CA	activates	gene	0.95
PIK3CA	activates	gene	0.90
PTEN	inhibits	gene	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K-AKT-MTOR PATHWAY in their description or question text

No additional research found