protein

CNR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

222Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CNR1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, causes, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Dementia. Connected to 48 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CNR1
Full Name	Cannabinoid Receptor 1
Chromosome	6q25.2
Function	The CNR1 gene encodes the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor that is the most abundant cannabinoid receptor in the brain.
Molecular Weight	53 kDa
Pathways	MAPK pathway
UniProt ID	P21554
NCBI Gene ID	1268
Ensembl ID	ENSG00000118432
OMIM	114010
GeneCards	CNR1
Human Protein Atlas	CNR1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, depression, neurodegeneration
Known Drugs/Compounds	cannabinoids
Interactions	AKT, ALZHEIMER, AND, ANXIETY, AR, BDNF
KG Connections	222 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNR1 — AlphaFold P21554 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CNR1 Gene

gene · 648 words

→

CNR1 Protein

protein · 565 words

→

Pathway Diagram

graph TD
    CNR1["CNR1"]
    Cannabinoid_CB_1__Receptor_Evoked_Signal(["Cannabinoid CB(1) Receptor-Evoked Signalling"])
    CNR1 -->|"mediates"| Cannabinoid_CB_1__Receptor_Evoked_Signal
    Dementia{"Dementia"}
    CNR1 -->|"regulates"| Dementia
    Inflammation{"Inflammation"}
    CNR1 -->|"regulates"| Inflammation
    Ms{"Ms"}
    CNR1 -->|"regulates"| Ms
    CTSD["CTSD"]
    CNR1 -->|"therapeutic target"| CTSD
    NME1["NME1"]
    CNR1 -->|"therapeutic target"| NME1
    CACNA1E["CACNA1E"]
    CNR1 -->|"therapeutic target"| CACNA1E
    CACNA2D3["CACNA2D3"]
    CNR1 -->|"therapeutic target"| CACNA2D3
    PRKAB1["PRKAB1"]
    CNR1 -->|"therapeutic target"| PRKAB1
    DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
    CNR1 -->|"therapeutic target"| DIABETIC_RETINOPATHY
    EPAS1["EPAS1"]
    CNR1 -->|"therapeutic target"| EPAS1
    CEBPA["CEBPA"]
    CNR1 -->|"therapeutic target"| CEBPA
    GAP43["GAP43"]
    GAP43 -->|"interacts with"| CNR1
    GAP43 -->|"modulates"| CNR1
    EPAS1 -->|"therapeutic target"| CNR1
    CACNG6["CACNG6"]
    CACNG6 -->|"therapeutic target"| CNR1
    BIN1["BIN1"]
    BIN1 -->|"therapeutic target"| CNR1
    CHRNA2["CHRNA2"]
    CHRNA2 -->|"therapeutic target"| CNR1
    CEBPA -->|"therapeutic target"| CNR1
    GENES["GENES"]
    GENES -->|"therapeutic target"| CNR1
    NME1 -->|"therapeutic target"| CNR1
    PRKAB1 -->|"therapeutic target"| CNR1
    CACNA1E -->|"therapeutic target"| CNR1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"regulates"| CNR1
    style CNR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (142)

Target	Relation	Type	Str
neuronal signaling	mediates	pathway	0.90
synaptic transmission	regulates	process	0.90
presynaptic terminal	expressed_in	cell_type	0.90
metabotropic signaling	involved_in	process	0.85
MAPK signaling	participates_in	pathway	0.70
Ms	regulates	disease	0.65
Depression	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	regulates	disease	0.65
Dementia	regulates	disease	0.65
Depression	causes	disease	0.65
Alzheimer	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Autism	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Anxiety	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Depression	interacts_with	disease	0.65
Epilepsy	interacts_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
IL6	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
GRIK1	interacts_with	gene	0.60
MAPK10	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
AKT1	therapeutic_target	gene	0.60
PIK3R1	interacts_with	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
BTG2	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
AND	regulates	gene	0.60
MAPK	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
PGR	interacts_with	gene	0.60
Rb	regulates	protein	0.60
CXCL8	associated_with	gene	0.60
HSP90	associated_with	gene	0.60
HSP90	targets	gene	0.60
IL1B	regulates	gene	0.60
IL6	regulates	gene	0.60
TP53	regulates	gene	0.60
VEGFA	regulates	gene	0.60

Incoming (80)

Source	Relation	Type	Str
cannabinoids	binds	compound	0.95
SOD1	regulates	gene	0.60
IL6	causes	gene	0.60
TP53	causes	gene	0.60
ACTB	causes	gene	0.60
SNCA	regulates	gene	0.60
NRF2	causes	gene	0.60
APP	causes	gene	0.60
CASP3	causes	gene	0.60
NFE2L2	regulates	gene	0.60
VEGFA	causes	gene	0.60
IL1B	causes	gene	0.60
BDNF	expressed_in	gene	0.60
AR	interacts_with	gene	0.60
GENES	therapeutic_target	gene	0.60
MAPK	regulates	gene	0.60
APP	associated_with	gene	0.60
APP	targets	gene	0.60
NME1	therapeutic_target	gene	0.60
PRKAB1	therapeutic_target	gene	0.60
CACNA1E	therapeutic_target	gene	0.60
AKT	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
PPAR	interacts_with	gene	0.60
NEFL	regulates	gene	0.60
RGS4	regulates	gene	0.60
TAU	expressed_in	gene	0.60
NEFM	regulates	gene	0.60
AKT1	targets	gene	0.60
BDNF	activates	gene	0.60
BDNF	causes	gene	0.60
INFLAMMATION	regulates	gene	0.60
GENES	regulates	gene	0.60
EPAS1	therapeutic_target	gene	0.60
CACNG6	therapeutic_target	gene	0.60
BIN1	therapeutic_target	gene	0.60
CHRNA2	therapeutic_target	gene	0.60
CEBPA	therapeutic_target	gene	0.60
ALS	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
DEPRESSION	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
ANXIETY	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
SYNAPSE	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
PARKINSON'S DISEASE	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CNR1 in their description or question text

No additional research found