pathway

glymphatic clearance

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about glymphatic clearance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

2Hypotheses

5Analyses

13Outgoing

50Incoming

0Experiments

5Debates

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🔀 Pathway Info

Name	glymphatic clearance
Key Genes/Proteins	ALS, APOE, APOE4, APP, AQP1, AQP4
Related Diseases	Alzheimer's disease
Linked Hypotheses	9 hypotheses

Pathway Diagram

graph TD
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| cortex["cortex"]
    style cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| blood_brain_barrier["blood-brain barrier"]
    style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| endothelial_cells["endothelial cells"]
    style endothelial_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    glymphatic_clearance["glymphatic clearance"] -->|"active in"| dopaminergic_neurons["dopaminergic neurons"]
    style dopaminergic_neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AQP4["AQP4"] -->|"participates in"| glymphatic_clearance["glymphatic clearance"]
    style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neurodegeneration["neurodegeneration"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    neuroinflammation["neuroinflammation"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    traumatic_brain_injury["traumatic brain injury"] -->|"involves"| glymphatic_clearance["glymphatic clearance"]
    style traumatic_brain_injury fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style glymphatic_clearance fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (13)

Target	Relation	Type	Str
Amyloid Clearance	involved_in	process	0.80
astrocytes	active_in	cell_type	0.80
TAU	activates	protein	0.65
AQP4	interacts_with	gene	0.65
NEURODEGENERATION	causes	disease	0.65
NEURODEGENERATION	exacerbates	disease	0.65
macrophages	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
dopaminergic neurons	active_in	cell_type	0.60
endothelial cells	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
FRONTAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Incoming (52)

Source	Relation	Type	Str
AQP4	mediates	protein	0.95
TDP-43	associated_with	protein	0.90
AQP4	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.90
neurodegeneration	involves	disease	0.80
AQP4	regulates	protein	0.80
PS1	participates_in	gene	0.75
astrocytes	active_in	cell_type	0.75
neuroinflammation	involves	disease	0.70
ALS	participates_in	gene	0.70
AQP4	facilitates	gene	0.70
AQP4	inhibits	gene	0.65
AQP4	activates	gene	0.65
APOE	participates_in	gene	0.65
APOE4	participates_in	gene	0.65
GABA	participates_in	gene	0.60
CK2	participates_in	gene	0.60
epilepsy	involves	disease	0.60
glioblastoma	involves	disease	0.60
P2Y12	participates_in	gene	0.60
GBA	participates_in	gene	0.60
LRRK2	participates_in	gene	0.60
multiple sclerosis	involves	disease	0.60
ATXN3	participates_in	gene	0.60
SCA3	participates_in	gene	0.60
CD36	participates_in	gene	0.60
PERK	participates_in	gene	0.60
traumatic brain injury	involves	disease	0.60
CCR2	participates_in	gene	0.60
ATP	participates_in	gene	0.60
GFAP	participates_in	gene	0.60
MAPK signaling	crosstalk_with	pathway	0.60
ERK1	participates_in	gene	0.60
stroke	involves	disease	0.60
APP	participates_in	gene	0.60
RNA	participates_in	gene	0.60
MAPK	participates_in	gene	0.60
Parkinson's disease	involves	disease	0.60
frontotemporal dementia	involves	disease	0.55
PDGFR	participates_in	gene	0.55
ALS	involves	disease	0.55
TREK-1	participates_in	gene	0.55
rapamycin	modulates	drug	0.55
GABRA1	participates_in	gene	0.55
neurons	active_in	cell_type	0.55
AQP1	participates_in	gene	0.55
tauopathy	involves	disease	0.55
LOX	participates_in	gene	0.55
DDC	participates_in	gene	0.55
inhibitory neurons	active_in	cell_type	0.55

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep-Dependent Glymphatic Clearance Expands the Therapeutic	0.780	neurodegeneration	What is the therapeutic window between t
Targeting AQP4 Sumoylation to Enhance Glymphatic Clearance a	0.490	neurodegeneration	What are the specific molecular mechanis