gene

ATOX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATOX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

34Outgoing

7Incoming

0Experiments

0Debates

Summary

Page for ATOX1 - Copper Chaperone

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🧬 Gene Info

Gene Symbol	ATOX1
Full Name	Antioxidant Protein 1 (Copper Chaperone)
Aliases	Page for ATOX1
Chromosome	5q31.2
Protein Type	Chaperone
Function	ATOX1 encodes a copper chaperone protein that plays a critical role in copper homeostasis.
Primary Expression	most tissues, with highest expression in:
Molecular Weight	9 kDa
Amino Acids	68 aa
Pathways	Mitophagy, Oxidative Stress
UniProt ID	ATOX1
NCBI Gene ID	475
Ensembl ID	ENSG00000137871
GeneCards	ATOX1
Human Protein Atlas	ATOX1
Associated Diseases	Cancer, Hepatocellular Carcinoma
Interactions	DJ-1
KG Connections	41 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATOX1 - Copper Chaperone

gene · 697 words

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ATOX1 Protein

protein · 651 words

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Pathway Diagram

graph TD
    ATOX1["ATOX1"]
    Copper_Homeostasis["Copper Homeostasis"]
    ATOX1 -->|"regulates"| Copper_Homeostasis
    PRRX2["PRRX2"]
    PRRX2 -->|"upregulates"| ATOX1
    MDC1["MDC1"]
    ATOX1 -->|"upregulates"| MDC1
    NCF1["NCF1"]
    ATOX1 -->|"upregulates"| NCF1
    PPA2["PPA2"]
    ATOX1 -->|"upregulates"| PPA2
    SOD3["SOD3"]
    ATOX1 -->|"upregulates"| SOD3
    Cancer{"Cancer"}
    ATOX1 -->|"associated_with"| Cancer
    Cell_Proliferation["Cell Proliferation"]
    ATOX1 -->|"associated_with"| Cell_Proliferation
    Cell_Invasion["Cell Invasion"]
    ATOX1 -->|"associated_with"| Cell_Invasion
    Cuproptosis["Cuproptosis"]
    ATOX1 -->|"associated_with"| Cuproptosis
    Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
    ATOX1 -->|"causes"| Mitochondrial_Dysfunction
    Hepatocellular_Carcinoma{"Hepatocellular Carcinoma"}
    ATOX1 -->|"associated_with"| Hepatocellular_Carcinoma
    Copper_Toxicity["Copper Toxicity"]
    ATOX1 -->|"associated_with"| Copper_Toxicity
    Mitochondrial_Function["Mitochondrial Function"]
    ATOX1 -->|"associated_with"| Mitochondrial_Function
    MAPK_Signaling(["MAPK Signaling"])
    ATOX1 -->|"activates"| MAPK_Signaling

Outgoing (34)

Target	Relation	Type	Str
Copper Homeostasis	regulates	process	0.90
Cell Invasion	associated_with	process	0.80
Cuproptosis	associated_with	process	0.80
Copper Toxicity	associated_with	process	0.80
Cancer	associated_with	disease	0.80
Hepatocellular Carcinoma	associated_with	disease	0.80
Cell Proliferation	associated_with	process	0.80
NCF1	upregulates	gene	0.80
PPA2	upregulates	gene	0.80
SOD3	upregulates	gene	0.80
MAPK Signaling	activates	pathway	0.80
MDC1	upregulates	gene	0.80
oxidative stress	protects_against	process	0.80
Traumatic Brain Injury	regulates	disease	0.65
MITOCHONDRIA	regulates	gene	0.60
Oxidative Stress	regulates	pathway	0.60
DJ-1	interacts_with	gene	0.60
Neuron	regulates	cell_type	0.60
Mitophagy	regulates	pathway	0.60
App	therapeutic_target	protein	0.60
MITOPHAGY	regulates	gene	0.60
Actin	regulates	protein	0.60
oxidative stress	associated_with	process	0.60
Neuron	expressed_in	cell_type	0.55
DJ-1	regulates	protein	0.50
mitophagy	regulates	pathway	0.50
oxidative stress	regulates	phenotype	0.50
BRAIN INJURY	regulates	concept	0.50
NEURONS	regulates	concept	0.50
Chaperone	regulates	pathway	0.50
oxidative stress	inhibits	phenotype	0.50
oxidative stress	expressed_in	phenotype	0.50
DJ-1	inhibits	protein	0.50
oxidative stress	co_mentioned	process	0.40

Incoming (7)

Source	Relation	Type	Str
PRRX2	upregulates	transcription_factor	0.90
MITOPHAGY	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
DJ-1	interacts_with	gene	0.60
MITOCHONDRIA	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATOX1 in their description or question text

No additional research found