gene

MAPK10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

40Outgoing

15Incoming

0Experiments

0Debates

Summary

MAPK10 (Mitogen-Activated Protein Kinase 10), also known as JNK3, is a neuronal-specific stress-activated kinase involved in apoptosis, synaptic plasticity, and neurodegeneration. It has been implicated in Alzheimer's disease, Parkinson's disease, and ...

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🧬 Gene Info

Gene Symbol	MAPK10
Aliases	Mitogen-Activated Protein Kinase 10
Chromosome	5q36.3
Protein Family	MAPK family, JNK subfamily
Protein Type	Serine/Threonine Kinase
Function	Regulatory and interaction domains
Primary Expression	the central nervous system and plays critical roles in stress responses, neuronal apoptosis, synaptic plasticity, and neurodegeneration
Molecular Weight	52 kDa
Amino Acids	464 aa
Exons	21
Pathways	MAPK
NCBI Gene ID	5602
GeneCards	MAPK10
Human Protein Atlas	MAPK10
Genomic position	Approximately 179,500,000-179,600,000 (GRCh38)
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, AR, CNR1, FERROPTOSIS, GENES, GRIK1
KG Connections	55 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK10["MAPK10"]
    Diabetes{"Diabetes"}
    MAPK10 -->|"therapeutic target"| Diabetes
    Als{"Als"}
    MAPK10 -->|"therapeutic target"| Als
    Atherosclerosis{"Atherosclerosis"}
    MAPK10 -->|"therapeutic target"| Atherosclerosis
    Aging{"Aging"}
    MAPK10 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    MAPK10 -->|"therapeutic target"| Ms
    GENES["GENES"]
    MAPK10 -->|"therapeutic target"| GENES
    APOE["APOE"]
    MAPK10 -->|"therapeutic target"| APOE
    SIGLEC1["SIGLEC1"]
    MAPK10 -->|"associated with"| SIGLEC1
    SPR["SPR"]
    MAPK10 -->|"therapeutic target"| SPR
    Jak_Stat(["Jak-Stat"])
    MAPK10 -->|"therapeutic target"| Jak_Stat
    Nf__b(["Nf-Kappab"])
    MAPK10 -->|"therapeutic target"| Nf__b
    Mapk(["Mapk"])
    MAPK10 -->|"associated with"| Mapk
    AGING["AGING"]
    AGING -->|"therapeutic target"| MAPK10
    JAK["JAK"]
    JAK -->|"therapeutic target"| MAPK10
    SIGLEC1 -->|"associated with"| MAPK10
    NF__B["NF-KappaB"]
    NF__B -->|"therapeutic target"| MAPK10
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"therapeutic target"| MAPK10
    SPR -->|"therapeutic target"| MAPK10
    APOE -->|"therapeutic target"| MAPK10
    JNK["JNK"]
    JNK -->|"activates"| MAPK10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| MAPK10
    style MAPK10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (40)

Target	Relation	Type	Str
MAPK signaling	participates_in	pathway	0.70
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
SLC32A1	targets	gene	0.60
MAPT	implicated_in	gene	0.60
SLC32A1	implicated_in	gene	0.60
MAPT	interacts_with	gene	0.60
PGR	interacts_with	gene	0.60
PIK3R1	interacts_with	gene	0.60
GENES	therapeutic_target	gene	0.60
Jak-Stat	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
MAPK	associated_with	gene	0.60
Mapk	associated_with	pathway	0.60
NF-ΚB	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
MAPT	targets	gene	0.60
AUTOPHAGY	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mapk	regulates	pathway	0.60
Glycolysis	regulates	pathway	0.60
POSTN	targets	gene	0.60
autophagy pathway	participates_in	pathway	0.60
JNK3	activates	gene	0.60
GENES	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
RNA	regulates	gene	0.60
Mapk	activates	pathway	0.60
LNCRNA	regulates	gene	0.60
APOE	therapeutic_target	gene	0.60
SIGLEC1	associated_with	gene	0.60
SPR	therapeutic_target	gene	0.60

Incoming (15)

Source	Relation	Type	Str
AND	associated_with	gene	0.60
JNK	activates	gene	0.60
AGING	therapeutic_target	gene	0.60
JAK	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
SIGLEC1	associated_with	gene	0.60
SPR	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
GLUL	targets	gene	0.60
GLUL	implicated_in	gene	0.60
AR	interacts_with	gene	0.60
CNR1	interacts_with	gene	0.60
GRIK1	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK10 in their description or question text

No additional research found