gene

NPAS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

39Outgoing

32Incoming

0Experiments

0Debates

Summary

Page for NPAS4 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NPAS4
Full Name	Neuronal PAS domain protein 4
Chromosome	19q13.3
Protein Family	bHLH-PAS transcription factor family
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	102 kDa
Amino Acids	892 aa
Exons	9 exons
Pathways	Autophagy, Notch
GeneCards	NPAS4
Human Protein Atlas	NPAS4
Chromosomal location	19q13.3
Gene length	~13 kb
mRNA length	~2.8 kb
Associated Diseases	neurodegeneration
Interactions	App, ARNT, AUTOPHAGY, BDNF, BRAIN INJURY, C-FOS
KG Connections	71 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NPAS4 Gene

gene · 1499 words

→

NPAS4 Protein

protein · 637 words

→

Pathway Diagram

graph TD
    NPAS4["NPAS4"]
    Alzheimer{"Alzheimer"}
    NPAS4 -->|"regulates"| Alzheimer
    Ms{"Ms"}
    NPAS4 -->|"regulates"| Ms
    APP["APP"]
    NPAS4 -->|"regulates"| APP
    Notch(["Notch"])
    NPAS4 -->|"regulates"| Notch
    neurodegeneration["neurodegeneration"]
    NPAS4 -->|"implicated in"| neurodegeneration
    APLP2["APLP2"]
    APLP2 -->|"regulates"| NPAS4
    APLP1["APLP1"]
    APLP1 -->|"regulates"| NPAS4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| NPAS4
    style NPAS4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	activates	disease	0.65
AND	expressed_in	gene	0.60
AND	regulates	gene	0.60
HDAC3	activates	gene	0.60
BDNF	expressed_in	gene	0.60
FOXP1	activates	gene	0.60
HDAC3	regulates	gene	0.60
STAT3	activates	gene	0.60
GRIN2B	regulates	gene	0.60
Notch	regulates	pathway	0.60
Epigenetic	activates	pathway	0.60
C-FOS	activates	gene	0.60
Neuron	activates	cell_type	0.60
Autophagy	regulates	pathway	0.60
C-FOS	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
Bdnf	expressed_in	protein	0.60
AUTOPHAGY	regulates	gene	0.60
DLG4	regulates	gene	0.60
Ras	activates	protein	0.60
App	inhibits	protein	0.60
APP	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
NR2B	regulates	protein	0.50
PSD95	regulates	gene	0.50
HDAC3	inhibits	gene	0.50
BRAIN INJURY	activates	concept	0.50
CHIP	activates	protein	0.50
NEURONS	activates	concept	0.50
WAS	activates	protein	0.50
Neuroprotection	activates	process	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
inflammation	inhibits	pathway	0.50
BRAIN INJURY	inhibits	concept	0.50

Incoming (32)

Source	Relation	Type	Str
BDNF	associated_with	gene	0.80
APLP2	regulates	gene	0.60
APLP1	regulates	gene	0.60
NR2B	regulates	gene	0.60
PSD95	regulates	gene	0.60
FOS	regulates	gene	0.60
C-FOS	regulates	gene	0.60
HDAC3	inhibits	protein	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HDAC3	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	regulates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
C-FOS	activates	gene	0.60
PER	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
BRAIN INJURY	activates	gene	0.60
BDNF	expressed_in	gene	0.60
STAT3	activates	gene	0.60
FOS	activates	gene	0.60
ARNT	regulates	gene	0.60
FOXP1	activates	gene	0.60
Autophagy	inhibits	process	0.50
AUTOPHAGY	activates	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
BDNF	regulates	gene	0.50
BDNF	activates	gene	0.50
ARNT	activates	gene	0.50
HDAC3	activates	gene	0.50
BDNF	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPAS4 in their description or question text

No additional research found