gene

GRID1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRID1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

23Outgoing

13Incoming

0Experiments

0Debates

Summary

GRID1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, interacts with, implicated in. Associated with Ms. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GRID1
Full Name	Glutamate Ionotropic Receptor Delta Type Subunit 1
Protein Type	Receptor
Function	GRID1 (Glutamate Receptor Ionotropic Delta 1), also known as GluRδ1, is a member of the ionotropic glutamate receptor family.
Primary Expression	Prefrontal Cortex, Cortex, Ventral Tegmental Area, Substantia Nigra
Pathways	Autophagy
Ensembl ID	ENSG00000148677
GeneCards	GRID1
Human Protein Atlas	GRID1
Ligand-binding domain (LBD)	Contains the glutamate binding site (though ligand gating is non-functional)
Three transmembrane domains	Form the ion channel pore
Intracellular C-terminal tail	Contains phosphorylation sites and PDZ-binding motifs
Associated Diseases	neurodegeneration
Interactions	Albumin, AUTOPHAGY, BECN1, CBLN1, CBLN2, GLUD1
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GRID1 — Glutamate Ionotropic Receptor Delta Type Subunit 1

gene · 2567 words

→

GluRδ1 (GRID1) Protein

protein · 1020 words

→

Pathway Diagram

graph TD
    GRID1["GRID1"]
    Ms{"Ms"}
    GRID1 -->|"inhibits"| Ms
    GLUD1["GLUD1"]
    GRID1 -->|"interacts with"| GLUD1
    LAMP1["LAMP1"]
    GRID1 -->|"inhibits"| LAMP1
    PRKCD["PRKCD"]
    GRID1 -->|"inhibits"| PRKCD
    CBLN1["CBLN1"]
    GRID1 -->|"inhibits"| CBLN1
    BECN1["BECN1"]
    GRID1 -->|"inhibits"| BECN1
    Autophagy(["Autophagy"])
    GRID1 -->|"inhibits"| Autophagy
    MAP1LC3B["MAP1LC3B"]
    GRID1 -->|"inhibits"| MAP1LC3B
    SQSTM1["SQSTM1"]
    GRID1 -->|"inhibits"| SQSTM1
    AND["AND"]
    GRID1 -->|"inhibits"| AND
    AUTOPHAGY["AUTOPHAGY"]
    GRID1 -->|"inhibits"| AUTOPHAGY
    neurodegeneration["neurodegeneration"]
    GRID1 -->|"implicated in"| neurodegeneration
    SQSTM1 -->|"inhibits"| GRID1
    MAP1LC3B -->|"inhibits"| GRID1
    CBLN1 -->|"inhibits"| GRID1
    LAMP1 -->|"inhibits"| GRID1
    BECN1 -->|"inhibits"| GRID1
    style GRID1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (23)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Ms	inhibits	disease	0.65
SLC17A7	expressed_in	gene	0.60
GRIN2B	expressed_in	gene	0.60
Dopaminergic	activates	cell_type	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	expressed_in	gene	0.60
CBLN2	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
Autophagy	inhibits	pathway	0.60
LAMP1	inhibits	gene	0.60
PRKCD	inhibits	gene	0.60
CBLN1	inhibits	gene	0.60
GLUD1	interacts_with	gene	0.60
MAP1LC3B	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
Albumin	activates	protein	0.60
Ventral Tegmental Area	expressed_in	brain_region	0.55
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Substantia Nigra	expressed_in	brain_region	0.55

Incoming (13)

Source	Relation	Type	Str
GRIN2B	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
SQSTM1	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
CBLN1	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
GLUD1	interacts_with	gene	0.60
GRID2	expressed_in	gene	0.60
GLUD2	transports	gene	0.60
SYNAPSE	interacts_with	gene	0.60
SLC17A7	expressed_in	protein	0.50
SCHIZOPHRENIA	expressed_in	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRID1 in their description or question text

No additional research found