gene

GRIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

32Outgoing

26Incoming

0Experiments

0Debates

Summary

GRIN1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, implicated in. Associated with Als, Inflammation, Ms. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GRIN1
Chromosome	9q34.1
Protein Type	Protein
Function	of 938 amino acids
Molecular Weight	105 kDa
Amino Acids	938 aa
Exons	21
Pathways	SRC-mediated Phosphorylation
UniProt ID	Search UniProt
GeneCards	GRIN1
Human Protein Atlas	GRIN1
Associated Diseases	Huntington's disease, Memory Impairment
Known Drugs/Compounds	D-glutamate
Interactions	ADRA1A, ADRA1B, DRD1, DRD2, GRIA1, HCRTR1
KG Connections	58 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GRIN1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRIN1["GRIN1"]
    Ms{"Ms"}
    GRIN1 -->|"activates"| Ms
    Als{"Als"}
    GRIN1 -->|"activates"| Als
    Inflammation{"Inflammation"}
    GRIN1 -->|"therapeutic target"| Inflammation
    GRIN1 -->|"therapeutic target"| Als
    HCRTR1["HCRTR1"]
    GRIN1 -->|"activates"| HCRTR1
    Epigenetic(["Epigenetic"])
    GRIN1 -->|"activates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    GRIN1 -->|"activates"| Dna_Methylation
    ADAM10["ADAM10"]
    GRIN1 -->|"therapeutic target"| ADAM10
    Oxidative_Stress(["Oxidative Stress"])
    GRIN1 -->|"therapeutic target"| Oxidative_Stress
    Nf__b(["Nf-Kappab"])
    GRIN1 -->|"therapeutic target"| Nf__b
    Apoptosis(["Apoptosis"])
    GRIN1 -->|"therapeutic target"| Apoptosis
    neurodegeneration["neurodegeneration"]
    GRIN1 -->|"implicated in"| neurodegeneration
    DRD2["DRD2"]
    DRD2 -->|"activates"| GRIN1
    HRH3["HRH3"]
    HRH3 -->|"activates"| GRIN1
    HCRTR2["HCRTR2"]
    HCRTR2 -->|"activates"| GRIN1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| GRIN1
    DRD1["DRD1"]
    DRD1 -->|"activates"| GRIN1
    GRIA1["GRIA1"]
    GRIA1 -->|"activates"| GRIN1
    ADRA1A["ADRA1A"]
    ADRA1A -->|"activates"| GRIN1
    HRH1["HRH1"]
    HRH1 -->|"activates"| GRIN1
    GENES["GENES"]
    GENES -->|"therapeutic target"| GRIN1
    CAPN1["CAPN1"]
    CAPN1 -->|"therapeutic target"| GRIN1
    TTR["TTR"]
    TTR -->|"therapeutic target"| GRIN1
    LGALS3["LGALS3"]
    LGALS3 -->|"therapeutic target"| GRIN1
    style GRIN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
calcium signaling	mediates	process	0.90
D-glutamate	interacts_with	compound	0.75
PLP1	regulates	gene	0.70
GRIN2B	regulates	gene	0.70
MAPT	regulates	gene	0.70
IDE	regulates	gene	0.70
PSEN2	regulates	gene	0.70
GRIN2B	expresses	gene	0.70
Memory Impairment	associated_with	phenotype	0.70
Alzheimer'S Disease	involved_in	disease	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Oxidative Stress	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
ADAM10	therapeutic_target	gene	0.60
Dna Methylation	activates	pathway	0.60
HCRTR1	activates	gene	0.60
HCN1	associated_with	gene	0.60
KMT2D	associated_with	gene	0.60
MECP2	associated_with	gene	0.60
Epigenetic	activates	pathway	0.60
GRIN2B	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.55
Huntington's disease	causes	disease	0.55
HTT	causes	gene	0.55
MBNL1	causes	gene	0.55
GRIN2A	co_discussed	gene	0.40

Incoming (26)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GRIN1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
APP	regulates	gene	0.70
ACSL4	associated_with	gene	0.60
DRD2	activates	gene	0.60
HRH3	activates	gene	0.60
HCRTR2	activates	gene	0.60
ADRA1B	activates	gene	0.60
DRD1	activates	gene	0.60
GRIA1	activates	gene	0.60
ADRA1A	activates	gene	0.60
HRH1	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
AD	regulates	gene	0.60
CAPN1	therapeutic_target	gene	0.60
TTR	therapeutic_target	gene	0.60
LGALS3	therapeutic_target	gene	0.60
CTSD	therapeutic_target	gene	0.60
GRB2	therapeutic_target	gene	0.60
TLR4	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
RPS6KA1	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
CACNA1G	causes	gene	0.55
HUNTINGTON'S DISEASE	associated_with	disease	0.50
HUNTINGTON	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GRIN1 in their description or question text

No additional research found