protein

C-FOS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-FOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

C-FOS is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Alzheimer. Connected to 129 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	C-FOS
Primary Expression	Prefrontal Cortex, Cortex, Thalamus, Hypothalamus, Spinal Cord
Molecular Weight	62 kDa
Amino Acids	380 aa
Pathways	MAPK pathway
GeneCards	C-FOS
Human Protein Atlas	C-FOS
Associated Diseases	Als
Interactions	Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, App
KG Connections	255 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    C_FOS["C-FOS"]
    C_FOS -->|"upregulates"| EPHA5["EPHA5"]
    C_FOS -->|"regulates"| neural_plasticity["neural plasticity"]
    C_FOS -->|"contributes to"| Anxiety["Anxiety"]
    C_FOS -->|"contributes to"| Ms["Ms"]
    C_FOS -->|"activates"| Als["Als"]
    C_FOS -->|"activates"| Leukemia["Leukemia"]
    C_FOS -->|"activates"| Tumor["Tumor"]
    psilocybin["psilocybin"] -->|"activates"| C_FOS
    ketamine["ketamine"] -->|"activates"| C_FOS
    FOS["FOS"] -->|"activates"| C_FOS
    EPO["EPO"] -->|"activates"| C_FOS
    JUNB["JUNB"] -->|"activates"| C_FOS
    MYC["MYC"] -->|"activates"| C_FOS
    CYTOKINES["CYTOKINES"] -->|"expressed in"| C_FOS
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| C_FOS
    TNF["TNF"] -->|"activates"| C_FOS

Outgoing (166)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:C-FOS	data_in	dataset_row	0.00
EPHA5	upregulates	gene	0.80
Inflammation	activates	disease	0.75
Als	expressed_in	disease	0.75
Als	activates	disease	0.75
JUN	activates	gene	0.70
TNF-Α	activates	gene	0.70
neural plasticity	regulates	process	0.70
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
Migraine	activates	disease	0.65
ALS	activates	disease	0.65
Depression	inhibits	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Epilepsy	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	activates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Ischemia	activates	disease	0.65
Als	associated_with	disease	0.65
Leukemia	activates	disease	0.65
Tumor	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Retinopathy	activates	disease	0.65
Ms	contributes_to	disease	0.65
ALS	regulates	disease	0.65
Anxiety	contributes_to	disease	0.65
SDHB	activates	gene	0.60
Dna Methylation	activates	pathway	0.60
FOS	activates	gene	0.60
Differentiation	causes	pathway	0.60
CYTOKINES	activates	gene	0.60
Macrophage	activates	cell_type	0.60
INOS	activates	gene	0.60
AND	inhibits	gene	0.60
GSH	activates	gene	0.60
FOS	regulates	gene	0.60
Sleep-Wake Cycle	activates	pathway	0.60
TNC	activates	gene	0.60
Autophagy	associated_with	pathway	0.60
STAT3	inhibits	gene	0.60
Apoptosis	activates	pathway	0.60
SYK	activates	gene	0.60
NLRP3	activates	gene	0.60

Incoming (95)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:C-FOS	data_in	dataset_row	0.00
FOS	activates	gene	0.70
FOS	expressed_in	gene	0.70
TNF	activates	gene	0.70
ketamine	activates	drug	0.70
CYTOKINES	activates	gene	0.70
psilocybin	activates	drug	0.70
FOS	regulates	gene	0.70
NRF1	activates	gene	0.60
VIRAL INFECTIONS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
NPAS4	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
GENES	regulates	gene	0.60
NR2B	regulates	gene	0.60
PSD95	regulates	gene	0.60
FOS	associated_with	gene	0.60
VHL	activates	gene	0.60
MBD1	activates	gene	0.60
ARC	inhibits	gene	0.60
MYC	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
EPO	activates	gene	0.60
GFAP	activates	gene	0.60
ASTROCYTES	regulates	gene	0.60
C-JUN	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
SIRT1	regulates	gene	0.60
NPAS4	regulates	gene	0.60
JUNB	activates	gene	0.60
INOS	activates	gene	0.60
DNA	activates	gene	0.60
NF-ΚB	activates	gene	0.60
IFN	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
IFN-Γ	activates	gene	0.60
HO-1	inhibits	gene	0.60
TLR4	activates	gene	0.60
ANXIETY	contributes_to	gene	0.60
CD38	activates	gene	0.60
HTR1D	inhibits	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURON	activates	gene	0.60
PKC	activates	gene	0.60
FOSB	activates	gene	0.60
CX3CR1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity