concept

DENTATE GYRUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENTATE GYRUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

198Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DENTATE GYRUS
Key Genes/Proteins	ACHE, AKT, ALPHA-SYNUCLEIN, AMYLOID, AMYLOID-BETA, APP
Related Diseases	AGING, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, ANGIOGENESIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mossy-cells-dentate-gyrus

cell_type · 2831 words

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Pathway Diagram

graph TD
    DENTATE_GYRUS["DENTATE GYRUS"]
    DENTATE_GYRUS -->|"involved_in"| Cognition["Cognition"]
    DENTATE_GYRUS -->|"expressed in"| adult_neurogenesis["adult neurogenesis"]
    DENTATE_GYRUS -->|"inhibits"| NEUROGENESIS["NEUROGENESIS"]
    DENTATE_GYRUS -->|"inhibits"| NEURON["NEURON"]
    DENTATE_GYRUS -->|"inhibits"| STING["STING"]
    DENTATE_GYRUS -->|"regulates"| INTERNEURON["INTERNEURON"]
    DENTATE_GYRUS -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| DENTATE_GYRUS
    ANXIETY["ANXIETY"] -->|"causes"| DENTATE_GYRUS
    AMYLOID["AMYLOID"] -->|"activates"| DENTATE_GYRUS
    ALZHEIMER["ALZHEIMER"] -->|"impairs"| DENTATE_GYRUS
    ALZHEIMER_S["ALZHEIMER'S"] -->|"impairs"| DENTATE_GYRUS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"impairs"| DENTATE_GYRUS
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"expressed in"| DENTATE_GYRUS
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| DENTATE_GYRUS

Outgoing (57)

Target	Relation	Type	Str
Cognition	involved_in	phenotype	0.85
Interneuron Transcriptional Changes	expressed_in	process	0.85
SYNAPTIC PLASTICITY	activates	phenotype	0.70
NEUROGENESIS	regulates	phenotype	0.70
adult neurogenesis	expressed_in	process	0.70
TAU	phosphorylates	gene	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
AGING	activates	phenotype	0.65
APP	associated_with	gene	0.65
NEURON	inhibits	cell_type	0.65
STING	inhibits	gene	0.60
HIPPOCAMPUS	expressed_in	brain_region	0.60
NEURON	regulates	cell_type	0.60
INTERNEURON	regulates	cell_type	0.60
PI3K	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
AKT	associated_with	gene	0.50
STEM CELLS	associated_with	cell_type	0.50
BDNF	associated_with	gene	0.50
ANGIOGENESIS	associated_with	phenotype	0.50
PSD95	associated_with	gene	0.50
FLUOXETINE	associated_with	drug	0.50
ACHE	associated_with	gene	0.45
NEURON	associated_with	cell_type	0.45
AMYLOID-BETA	associated_with	protein	0.45
AMYLOID	associated_with	protein	0.45
TAU	associated_with	protein	0.45
MELATONIN	associated_with	drug	0.45
ASTROGLIOSIS	associated_with	phenotype	0.45
SEMAGLUTIDE	associated_with	drug	0.45
ASTROCYTES	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CASP3	associated_with	gene	0.45
ASTROCYTE	associated_with	cell_type	0.45
CX3CR1	associated_with	gene	0.45
SENESCENCE	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
PHAGOCYTOSIS	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NEUROGENESIS	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
TH	associated_with	gene	0.45
EPO	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
GFAP	associated_with	gene	0.45
RIPK1	associated_with	gene	0.45
RIPK3	associated_with	gene	0.45
T CELLS	associated_with	cell_type	0.45
NEURONS	co_discussed	cell_type	0.40

Incoming (141)

Source	Relation	Type	Str
Alzheimer's disease	affects	disease	0.80
FLUOXETINE	treats	drug	0.70
RNA	expressed_in	gene	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
NEURONS	produces	cell_type	0.70
aging	affects	disease	0.70
NEUROGENESIS	activates	phenotype	0.70
epilepsy	affects	disease	0.70
synaptic plasticity	active_in	pathway	0.70
HIPPOCAMPUS	inhibits	brain_region	0.65
AMYLOID-BETA	phosphorylates	gene	0.65
CA1	regulates	brain_region	0.65
CA3	regulates	brain_region	0.65
CORTEX	regulates	brain_region	0.65
T CELLS	activates	cell_type	0.65
TAU	activates	protein	0.65
CORTEX	activates	brain_region	0.65
MICROGLIA	regulates	cell_type	0.65
ANXIETY	causes	disease	0.60
ALZHEIMER	impairs	disease	0.60
ALZHEIMER'S	impairs	disease	0.60
ALZHEIMER'S DISEASE	associated_with	disease	0.60
PTSD	affects	disease	0.60
APP	expressed_in	gene	0.60
NLGN1	expressed_in	gene	0.60
neurodegeneration	affects	disease	0.60
BDNF	expressed_in	gene	0.60
anxiety	affects	disease	0.60
depression	affects	disease	0.60
axon	enriched_in	organelle	0.60
Parkinson's disease	affects	disease	0.60
GFAP	expressed_in	gene	0.55
APP	expressed_in	gene	0.55
DCX	expressed_in	gene	0.55
SMAD2	expressed_in	gene	0.55
SMAD4	expressed_in	gene	0.55
TNF	expressed_in	gene	0.55
AMYLOID	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
NEUROTOXICITY	expressed_in	gene	0.55
AKT	expressed_in	gene	0.55
GSK-3Β	expressed_in	gene	0.55
AGING	expressed_in	gene	0.55
NEUROINFLAMMATION	expressed_in	gene	0.55
CYTOKINES	expressed_in	gene	0.55
IL-6	expressed_in	gene	0.55
GUT-BRAIN AXIS	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
ERK	expressed_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DENTATE GYRUS in their description or question text

No additional research found