gene

UQCRFS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UQCRFS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

16Outgoing

3Incoming

0Experiments

0Debates

Summary

UQCRFS1 (Ubiquinol-Cytochrome c Reductase Core Protein 1) is a core subunit of mitochondrial complex III (cytochrome bc1 complex) essential for electron transport and ATP synthesis, implicated in neurodegeneration through mitochondrial dysfunction.

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🧬 Gene Info

Gene Symbol	UQCRFS1
Full Name	Ubiquinol-Cytochrome c Reductase Core Protein 1
Aliases	Rieske iron-sulfur protein
Chromosome	19q12
Function	is a nuclear-encoded mitochondrial protein that serves as a critical core component of complex III (cytochrome bc1 complex) in the electron transport chain[@craft2011].
Primary Expression	High in brain, heart, muscle
Molecular Weight	30 kDa
Amino Acids	274 aa
Pathways	mitochondrial function
UniProt ID	P31930
NCBI Gene ID	27089
Ensembl ID	ENSG00000127540
OMIM	191317
GeneCards	UQCRFS1
Human Protein Atlas	UQCRFS1
Associated Diseases	Als, Cardiomyopathy, disease
Interactions	GENES
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: UQCRFS1 — AlphaFold P31930 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

UQCRFS1 Gene

gene · 2396 words

→

UQCRFS1 Protein

protein · 776 words

→

Pathway Diagram

graph TD
    UQCRFS1["UQCRFS1"]
    Ms{"Ms"}
    UQCRFS1 -->|"interacts with"| Ms
    Als{"Als"}
    UQCRFS1 -->|"associated with"| Als
    ALS{"ALS"}
    UQCRFS1 -->|"associated with"| ALS
    Mitochondrial_Function(["Mitochondrial Function"])
    UQCRFS1 -->|"protects against"| Mitochondrial_Function
    Complement(["Complement"])
    UQCRFS1 -->|"protects against"| Complement
    GENES["GENES"]
    UQCRFS1 -->|"causes"| GENES
    AND["AND"]
    UQCRFS1 -->|"causes"| AND
    Fibroblast["Fibroblast"]
    UQCRFS1 -->|"expressed in"| Fibroblast
    neurodegeneration["neurodegeneration"]
    UQCRFS1 -->|"implicated in"| neurodegeneration
    GENES -->|"interacts with"| UQCRFS1
    GENES -->|"causes"| UQCRFS1
    style UQCRFS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (16)

Target	Relation	Type	Str
Cardiomyopathy	associated_with	disease	0.65
Als	encodes	disease	0.65
ALS	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	associated_with	disease	0.65
AND	causes	gene	0.60
Mitochondrial Function	protects_against	pathway	0.60
Complement	protects_against	pathway	0.60
Fibroblast	associated_with	cell_type	0.60
mitochondrial function	participates_in	pathway	0.60
Fibroblast	transports	cell_type	0.60
GENES	causes	gene	0.60
Fibroblast	expressed_in	cell_type	0.55
FIBROBLASTS	associated_with	concept	0.50
Mitochondrial Function	expressed_in	pathway	0.50
disease	causes	disease	0.50

Incoming (3)

Source	Relation	Type	Str
GENES	interacts_with	gene	0.60
GENES	causes	gene	0.60
cardiomyopathy	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UQCRFS1 in their description or question text

No additional research found