Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about E2F3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
E2F3 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with ALS, Als, Ms. Connected to 13 entities in the SciDEX knowledge graph.
No AI portrait yet
| Gene Symbol | E2F3 |
| Full Name | E2F Transcription Factor 3 |
| Chromosome | 6p22 |
| Protein Family | E2F family of transcription factors |
| Protein Type | Transcription Factor |
| Function | It functions as part of a complex with retinoblastoma protein (pRb) |
| Primary Expression | various brain regions: |
| Amino Acids | 389 aa |
| Pathways | Cell Cycle, Neurogenesis, Notch, Tgf-Β, Wnt |
| UniProt ID | O00716 |
| NCBI Gene ID | 1871 |
| Ensembl ID | ENSG00000112242 |
| OMIM | 600427 |
| GeneCards | E2F3 |
| Human Protein Atlas | E2F3 |
| Associated Diseases | neurodegeneration |
| Interactions | AND, CTCF, E2F1, E2F2, E2F7, E2F8 |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
E2F3["E2F3"]
Ms{"Ms"}
E2F3 -->|"activates"| Ms
Als{"Als"}
E2F3 -->|"regulates"| Als
ALS{"ALS"}
E2F3 -->|"regulates"| ALS
E2F7["E2F7"]
E2F3 -->|"activates"| E2F7
E2F8["E2F8"]
E2F3 -->|"activates"| E2F8
Cell_Cycle(["Cell Cycle"])
E2F3 -->|"regulates"| Cell_Cycle
T_Cell["T Cell"]
E2F3 -->|"expressed in"| T_Cell
neurodegeneration["neurodegeneration"]
E2F3 -->|"implicated in"| neurodegeneration
E2F7 -->|"activates"| E2F3
E2F8 -->|"activates"| E2F3
E2F1["E2F1"]
E2F1 -->|"activates"| E2F3
E2F2["E2F2"]
E2F2 -->|"activates"| E2F3
DNA["DNA"]
DNA -->|"regulates"| E2F3
AND["AND"]
AND -->|"activates"| E2F3
style E2F3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| endocycle | regulates | process | 0.90 |
| G2/M transcriptional program | drives | pathway | 0.80 |
| Ms | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Rb | regulates | protein | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| E2F8 | activates | gene | 0.60 |
| E2F1 | activates | gene | 0.60 |
| E2F2 | activates | gene | 0.60 |
| CTCF | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| Hepatocyte | regulates | cell_type | 0.60 |
| E2F7 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Neurogenesis | regulates | pathway | 0.60 |
| Wnt | regulates | pathway | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Fibroblast | regulates | cell_type | 0.60 |
| WNT | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| NOTCH | regulates | gene | 0.60 |
| Tgf-Β | regulates | pathway | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
| Fibroblast | expressed_in | cell_type | 0.55 |
| CTCF | interacts_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity