gene

IGF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

0Analyses

50Outgoing

40Incoming

0Experiments

0Debates

Summary

IGF2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with Aging, Als, Alzheimer. Connected to 64 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IGF2
Aliases	Insulin-Like Growth Factor 2
Function	IGF2 serves multiple physiological functions
Molecular Weight	7.5 kDa
Amino Acids	24 aa
Pathways	Blood-Brain Barrier
UniProt ID	[P01344](https://www.uniprot.org/uniprot/P01344)
NCBI Gene ID	3481
GeneCards	IGF2
Human Protein Atlas	IGF2
Neuroprotection	IGF2 reduces amyloid-beta toxicity and tau hyperphosphorylation in cellular and animal models.[@duron2011]
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Interactions	AGING, AKT, AKT1, ALS, ALZHEIMER, amyotrophic lateral sclerosis
KG Connections	188 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF2["IGF2"]
    Synaptic_Plasticity(["Synaptic Plasticity"])
    IGF2 -->|"mediates"| Synaptic_Plasticity
    Memory["Memory"]
    IGF2 -->|"modulates"| Memory
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    IGF2 -->|"associated with"| Alzheimer_s_Disease
    Parkinson_s_Disease{"Parkinson's Disease"}
    IGF2 -->|"associated with"| Parkinson_s_Disease
    Huntington_s_Disease{"Huntington's Disease"}
    IGF2 -->|"associated with"| Huntington_s_Disease
    Neurodevelopmental_Disorders{"Neurodevelopmental Disorders"}
    IGF2 -->|"treats"| Neurodevelopmental_Disorders
    synaptic_plasticity(["synaptic plasticity"])
    IGF2 -->|"regulates"| synaptic_plasticity
    learning_and_memory(["learning and memory"])
    IGF2 -->|"activates"| learning_and_memory
    amyotrophic_lateral_sclerosis{"amyotrophic lateral sclerosis"}
    IGF2 -->|"biomarker for"| amyotrophic_lateral_sclerosis
    IGF2R["IGF2R"]
    IGF2 -->|"interacts with"| IGF2R
    Alzheimer_s_disease{"Alzheimer's disease"}
    IGF2 -->|"associated with"| Alzheimer_s_disease
    Parkinson_s_disease{"Parkinson's disease"}
    IGF2 -->|"associated with"| Parkinson_s_disease
    JUN["JUN"]
    JUN -->|"expressed in"| IGF2
    MIRNAS["MIRNAS"]
    MIRNAS -->|"therapeutic target"| IGF2
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic target"| IGF2
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"therapeutic target"| IGF2
    RB1["RB1"]
    RB1 -->|"regulates"| IGF2
    IGF2R -->|"expressed in"| IGF2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| IGF2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| IGF2
    style IGF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (148)

Target	Relation	Type	Str
Memory	associated_with	phenotype	0.95
Memory	regulates	process	0.95
Synaptic Plasticity	mediates	process	0.95
Memory	upregulates	phenotype	0.90
Neurodegenerative Diseases	therapeutic_target	disease	0.90
ALS	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.90
Memory Enhancement	promotes	phenotype	0.90
Parkinson's Disease	associated_with	disease	0.90
Neurodevelopmental Disorders	therapeutic_target	disease	0.90
normal growth and development	mediates	process	0.90
learning	regulates	process	0.90
Huntington's Disease	associated_with	disease	0.90
Cell Growth	involved_in	process	0.85
Cell Growth	regulates	process	0.85
Cell Migration	involved_in	process	0.85
Cell Survival	involved_in	process	0.85
Neurodevelopmental Disorders	treats	disease	0.85
Cell Survival	regulates	process	0.85
Huntington'S Disease	biomarker_for	disease	0.85
AGING	protects_against	process	0.85
NEURODEGENERATION	protects_against	process	0.85
Alzheimer'S Disease	biomarker_for	disease	0.85
Parkinson'S Disease	biomarker_for	disease	0.85
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.85
Parkinson's Disease	biomarker_for	disease	0.80
amyotrophic lateral sclerosis	implicated_in	disease	0.80
Huntington's disease	implicated_in	disease	0.80
Alzheimer's Disease	biomarker_for	disease	0.80
Cognitive Aging	protects_against	phenotype	0.80
MEMORY	enhances	process	0.80
Parkinson's disease	associated_with	disease	0.80
Alzheimer's disease	associated_with	disease	0.80
synaptic plasticity	regulates	process	0.70
neurons	expressed_in	cell_type	0.70
Huntington's disease	biomarker_for	disease	0.70
learning and memory	activates	process	0.70
amyotrophic lateral sclerosis	biomarker_for	disease	0.70
IGF2R	interacts_with	protein	0.70
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Ms	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Colorectal Cancer	inhibits	disease	0.65

Incoming (40)

Source	Relation	Type	Str
IGF2R domain 13	binds	protein	0.90
DOMAIN 13	binds	protein	0.85
AND	expressed_in	gene	0.60
GENES	causes	gene	0.60
AND	causes	gene	0.60
GENES	activates	gene	0.60
AND	regulates	gene	0.60
NEURON	activates	gene	0.60
ALS	interacts_with	gene	0.60
RB1	regulates	gene	0.60
GENES	protects_against	gene	0.60
IGF1	associated_with	gene	0.60
IGF2R	expressed_in	gene	0.60
DYNC1I1	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALS	activates	gene	0.60
AGING	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
JUN	expressed_in	gene	0.60
BAX	activates	gene	0.60
AKT1	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
IGF1R	inhibits	gene	0.60
BCL2	activates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
DYNC1I1	protects_against	gene	0.60
APOPTOSIS	inhibits	gene	0.60
RAS	associated_with	gene	0.60
CANCER	inhibits	gene	0.60
ALS	associated_with	entity	0.60
HUNTINGTON	associated_with	gene	0.60
TGM2	expressed_in	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF2 in their description or question text

No additional research found

IGF2

Understanding Entity Pages

Summary

Wiki Pages (8)

IGF2 (Insulin-Like Growth Factor 2)

IGF2 Protein (Insulin-like Growth Factor 2)

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

IGF2BP2

IGF2BP1

IGF2BP1 Protein

IGF2R Protein

IGF2BP2 Protein