gene

BLM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BLM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections

0Hypotheses

0Analyses

50Outgoing

37Incoming

0Experiments

0Debates

Summary

BLM is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with Aging, Als, Anxiety. Connected to 88 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BLM
Full Name	Bloom Syndrome Protein
Function	BLM is a 3'-5' DNA helicase with multiple cellular functions:
Pathways	Akt, Apoptosis, Autophagy, Cell Cycle, Dna Repair
Ensembl ID	ENSG00000197299
GeneCards	BLM
Human Protein Atlas	BLM
Associated Diseases	Fibrosis, Pulmonary Fibrosis
Interactions	Actin, AKT, AND, APOPTOSIS, ATM, AUTOPHAGY
KG Connections	138 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

BLM — Bloom Syndrome Protein

gene · 622 words

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Pathway Diagram

graph TD
    BLM["BLM"]
    Inflammation{"Inflammation"}
    BLM -->|"activates"| Inflammation
    Fibrosis{"Fibrosis"}
    BLM -->|"activates"| Fibrosis
    Als{"Als"}
    BLM -->|"activates"| Als
    Ms{"Ms"}
    BLM -->|"activates"| Ms
    BLM -->|"inhibits"| Als
    BLM -->|"inhibits"| Fibrosis
    Anxiety{"Anxiety"}
    BLM -->|"activates"| Anxiety
    Depression{"Depression"}
    BLM -->|"activates"| Depression
    Aging{"Aging"}
    BLM -->|"activates"| Aging
    Cancer{"Cancer"}
    BLM -->|"regulates"| Cancer
    BLM -->|"expressed in"| Als
    CX3CL1["CX3CL1"]
    BLM -->|"activates"| CX3CL1
    RAGE["RAGE"]
    RAGE -->|"activates"| BLM
    LGALS3["LGALS3"]
    LGALS3 -->|"activates"| BLM
    AKT["AKT"]
    AKT -->|"activates"| BLM
    MTOR["MTOR"]
    MTOR -->|"activates"| BLM
    PI3K["PI3K"]
    PI3K -->|"activates"| BLM
    STX11["STX11"]
    STX11 -->|"activates"| BLM
    BNIP3["BNIP3"]
    BNIP3 -->|"activates"| BLM
    MYC["MYC"]
    MYC -->|"inhibits"| BLM
    CANCER["CANCER"]
    CANCER -->|"regulates"| BLM
    ATM["ATM"]
    ATM -->|"activates"| BLM
    PDGFB["PDGFB"]
    PDGFB -->|"expressed in"| BLM
    style BLM fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (101)

Target	Relation	Type	Str
oxidative stress response	participates_in	pathway	0.80
Fibrosis	activates	disease	0.75
Fibrosis	inhibits	disease	0.75
CGAS-STING	activates	gene	0.70
Autophagy	activates	pathway	0.70
DNA	activates	gene	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Pulmonary Fibrosis	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
Senescence	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Aging	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Senescence	activates	disease	0.65
Als	expressed_in	disease	0.65
Breast Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Als	inhibits	disease	0.65
Depression	activates	disease	0.65
Pulmonary Fibrosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Anxiety	activates	disease	0.65
MIR-9-5P	activates	gene	0.60
YAP	activates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	activates	gene	0.60
IMMUNE INFILTRATION	activates	gene	0.60
CX3CL1	activates	gene	0.60
P62	activates	gene	0.60
SPP1	activates	gene	0.60
GAIN	activates	gene	0.60
YAP1	inhibits	gene	0.60
Rb	inhibits	protein	0.60
Akt	activates	pathway	0.60
Mtor	activates	pathway	0.60
Pi3K	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
NRF2	activates	gene	0.60
Immune Response	activates	pathway	0.60
Epithelial	activates	cell_type	0.60
Ras	inhibits	protein	0.60
STAT3	inhibits	gene	0.60

Incoming (37)

Source	Relation	Type	Str
PI3K	activates	gene	0.70
MITOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
STX11	activates	gene	0.60
ATM	activates	gene	0.60
MTOR	activates	gene	0.60
CANCER	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
BNIP3	activates	gene	0.60
MYC	inhibits	gene	0.60
AKT	activates	gene	0.60
BAX	inhibits	gene	0.60
P62	activates	gene	0.60
NRF2	activates	gene	0.60
SNAP25	activates	gene	0.60
PRDX3	inhibits	gene	0.60
FERROPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
ROS	activates	gene	0.60
PDGFB	expressed_in	gene	0.60
PINK1	activates	gene	0.60
GAIN	activates	gene	0.60
OGG1	activates	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
BCL-2	inhibits	gene	0.60
RAGE	activates	gene	0.60
LGALS3	activates	gene	0.60
TLR4	inhibits	gene	0.60
TNF	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BLM in their description or question text

No additional research found