Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ROCK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ROCK |
| Key Genes/Proteins | AKT, DMSO, EGF, GAP43, JAK, LC3 |
| Related Pathways | apoptosis pathway, autophagy pathway, JAK-STAT signaling, MAPK signaling |
Knowledge base pages for this entity
graph TD
ROCK[ROCK]
ROCK -->|activates| PI3K[PI3K]
ROCK -->|promotes| Axon_Regeneration[Axon Regeneration]
ROCK -->|promotes| Schwann_Cell_Proliferation[Schwann Cell Proliferation]
ROCK -->|expressed in| neurons[neurons]
ROCK -->|regulates| PI3K_AKT_GSK3__pathway[PI3K/AKT/GSK3β pathway]
ROCK -->|activates| neurodegeneration[neurodegeneration]
ROCK -->|inhibits| WIPI1[WIPI1]
ROCK -->|activates| ROCK1[ROCK1]
ROCK -->|activates| ROCK2[ROCK2]
ROCK -->|expressed in| Schwann_cells[Schwann cells]
Y27632[Y27632] -->|inhibits| ROCK
PI3K -->|part_of| ROCK
AKT[AKT] -->|regulates| ROCK
GAP43[GAP43] -->|activates| ROCK
MLCK[MLCK] -->|inhibits| ROCK
LC3[LC3] -->|inhibits| ROCK
PTEN[PTEN] -->|activates| ROCK| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ROCK | data_in | dataset_row | 0.00 |
| PI3K | activates | gene | 0.90 |
| Axon Regeneration | promotes | process | 0.90 |
| Schwann Cell Proliferation | promotes | process | 0.85 |
| neurons | expressed_in | cell_type | 0.80 |
| PI3K/AKT/GSK3β pathway | regulates | pathway | 0.70 |
| macrophages | expressed_in | cell_type | 0.60 |
| JAK-STAT signaling | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| YAP | regulates | gene | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| WIPI1 | inhibits | gene | 0.60 |
| ROCK1 | activates | gene | 0.60 |
| ROCK2 | activates | gene | 0.60 |
| Schwann cells | expressed_in | cell_type | 0.60 |
| TGF | associated_with | gene | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ROCK | data_in | dataset_row | 0.00 |
| Y27632 | inhibits | drug | 0.95 |
| PI3K | part_of | gene | 0.90 |
| PI3K | interacts_with | gene | 0.80 |
| AKT | regulates | gene | 0.70 |
| rapamycin | targets | drug | 0.60 |
| MAPK | associated_with | gene | 0.60 |
| DMSO | inhibits | gene | 0.60 |
| JAK | activates | gene | 0.60 |
| JAK | interacts_with | gene | 0.60 |
| GAP43 | regulates | gene | 0.60 |
| MLCK | inhibits | gene | 0.60 |
| LC3 | inhibits | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| PI3K | inhibits | gene | 0.60 |
| PI3K | expressed_in | gene | 0.60 |
| EGF | regulates | gene | 0.60 |
| GAP43 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ROCK in their description or question text
No additional research found