| Gene Symbol | DCX |
| Full Name | Doublecortin |
| Chromosome | Xq23 |
| Function | encodes a microtubule-associated protein essential for neuronal migration and cortical layering during fetal brain development. |
| Primary Expression | adult neurogenic niches where it regulates neuronal differentiation, and its dysfunction has been implicated in [Alzheimer's disease](/diseases/alzhei |
| Amino Acids | 366 aa |
| Pathways | Akt, Amyloid, Dendritic Spine, Differentiation, MAPK signaling |
| UniProt ID | [O43502](https://www.uniprot.org/uniprot/O43502) |
| Ensembl ID | ENSG00000077279 |
| GeneCards | DCX |
| Human Protein Atlas | DCX |
| PKA | Ser297, Ser302 — reduces microtubule binding |
| [CDK5](/proteins/cdk5) | Ser297 — disrupts neuronal migration |
| MARK kinases | Ser322 — destabilizes microtubules |
| Fetal brain | Peak expression during corticogenesis (gestational weeks 10-24) |
| Associated Diseases | AD, ADH, ALI, Als, AMI |
| Interactions | AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APP |
| KG Connections | 133 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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