gene

CD63

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD63: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

0Experiments

0Debates

Summary

CD63 (LAMP-3) is a tetraspanin protein involved in lysosomal function, exosome formation, and neurodegenerative diseases including Parkinson's and Alzheimer's.

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🧬 Gene Info

Gene Symbol	CD63
Aliases	LAMP-3
Chromosome	12q13.2
Function	is a member of the tetraspanin superfamily that plays crucial roles in membrane trafficking, lysosomal function, and exosome biogenesis.
Primary Expression	intracellular vesicles, including lysosomes, endosomes, and secretory granules[@matila1995][@tomlinson1999]
Subcellular Localization	CD63 primarily localizes to lysosomes (primary storage compartment), late endosomes (multivesicular body formation), sec
Amino Acids	238 aa
Exons	7
Pathways	oxidative stress response, phagocytosis, unfolded protein response
Ensembl ID	ENSG00000135404
GeneCards	CD63
Human Protein Atlas	CD63
Associated Diseases	Als
Interactions	Actin, ALZHEIMER, AMYLOID, AND, APOE, App
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD63

gene · 1300 words

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Pathway Diagram

graph TD
    CD63["CD63"]
    FERRITINH["FERRITINH"]
    CD63 -->|"associated with"| FERRITINH
    Cholesterol(["Cholesterol"])
    CD63 -->|"interacts with"| Cholesterol
    neurodegeneration["neurodegeneration"]
    CD63 -->|"implicated in"| neurodegeneration
    EXOSOMES["EXOSOMES"]
    EXOSOMES -->|"interacts with"| CD63
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"associated with"| CD63
    NPC1["NPC1"]
    NPC1 -->|"interacts with"| CD63
    style CD63 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
corneal epithelial homeostasis	contributes_to	process	0.90
limbal stem cells	expressed_in	cell_type	0.90
cell proliferation	promotes	process	0.85
KRT12	upregulates	gene	0.85
PAX6	regulates	gene	0.85
ALDH1A1	upregulates	gene	0.80
CLU	upregulates	gene	0.80
FERRITINH	associated_with	protein	0.80
corneal epithelium	therapeutic_target	cell_type	0.75
Als	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Atherosclerosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cardiovascular	regulates	disease	0.65
App	interacts_with	protein	0.60
stem cells	expressed_in	cell_type	0.60
RNA	regulates	gene	0.60
CD81	expressed_in	gene	0.60
CD4	inhibits	gene	0.60
CD9	associated_with	gene	0.60
GLS	associated_with	gene	0.60
L1CAM	associated_with	gene	0.60
CD9	activates	gene	0.60
RAB35	activates	gene	0.60
UGCG	activates	gene	0.60
RAB5	activates	gene	0.60
TAU	interacts_with	gene	0.60
AQP4	interacts_with	gene	0.60
CD81	associated_with	gene	0.60
Actin	interacts_with	protein	0.60
Interleukin	interacts_with	protein	0.60
Fus	interacts_with	protein	0.60
MICRORNAS	inhibits	gene	0.60
EXOSOMES	inhibits	gene	0.60
Microrna	inhibits	pathway	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	biomarker_for	gene	0.60
INFLAMMATION	inhibits	gene	0.60
GENES	inhibits	gene	0.60
lipid metabolism	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
AMYLOID	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
CD9	expressed_in	gene	0.60
CLU	expressed_in	gene	0.60

Incoming (20)

Source	Relation	Type	Str
ABCB5	biomarker_for	gene	0.60
ALDH1A1	expressed_in	gene	0.60
AND	associated_with	gene	0.60
GENES	regulates	gene	0.60
GFAP	interacts_with	gene	0.60
NPC1	interacts_with	gene	0.60
LAMP1	interacts_with	gene	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	associated_with	gene	0.60
MIRNAS	inhibits	gene	0.60
FOXP3	inhibits	gene	0.60
AND	biomarker_for	gene	0.60
SLC3A2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
CD9	interacts_with	gene	0.60
CD81	interacts_with	gene	0.60
APOE	activates	gene	0.55
autophagy	debate_co_mention	pathway	0.45
BMAL1	debate_co_mention	gene	0.45
APOE	debate_co_mention	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD63 in their description or question text

No additional research found