protein

DYNEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

303Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DYNEIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, causes, transports. Associated with ALS, Alzheimer, Tumor. Connected to 76 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DYNEIN
Full Name	Dynein — Cytoplasmic Dynein 1
Aliases	Cytoplasmic Dynein 1
Protein Type	Protein
Function	Dynein is a large motor protein complex that transports cargo along microtubules toward the minus end, powering retrograde axonal transport from nerve terminals to cell bodies
Molecular Weight	500 kDa
Pathways	Autophagy, Pyroptosis
UniProt ID	Search UniProt
GeneCards	DYNEIN
Human Protein Atlas	DYNEIN
Tail domain	The N-terminal tail (~200 kDa) mediates heavy chain dimerization and cargo binding through interaction with intermediate chains.
Associated Diseases	Als, disease, Parkinson's Disease
Interactions	A2M, Actin, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, AMYLOID
KG Connections	225 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DYNEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dynein Motor Protein

mechanism · 2466 words

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Pathway Diagram

graph TD
    DYNEIN["DYNEIN"]
    ALS{"ALS"}
    DYNEIN -->|"causes"| ALS
    Tumor{"Tumor"}
    DYNEIN -->|"interacts with"| Tumor
    DYNEIN -->|"interacts with"| ALS
    Alzheimer{"Alzheimer"}
    DYNEIN -->|"interacts with"| Alzheimer
    MICROTUBULES["MICROTUBULES"]
    DYNEIN -->|"interacts with"| MICROTUBULES
    PAFAH1B1["PAFAH1B1"]
    DYNEIN -->|"causes"| PAFAH1B1
    DAB1["DAB1"]
    DYNEIN -->|"causes"| DAB1
    REELIN["REELIN"]
    DYNEIN -->|"causes"| REELIN
    LMNA["LMNA"]
    DYNEIN -->|"interacts with"| LMNA
    Amyloid(["Amyloid"])
    DYNEIN -->|"interacts with"| Amyloid
    Apoptosis(["Apoptosis"])
    DYNEIN -->|"interacts with"| Apoptosis
    Axonal_Transport(["Axonal Transport"])
    DYNEIN -->|"transports"| Axonal_Transport
    CDK5["CDK5"]
    CDK5 -->|"causes"| DYNEIN
    AXON["AXON"]
    AXON -->|"causes"| DYNEIN
    LIS1["LIS1"]
    LIS1 -->|"interacts with"| DYNEIN
    NEURON["NEURON"]
    NEURON -->|"causes"| DYNEIN
    DCX["DCX"]
    DCX -->|"causes"| DYNEIN
    MAPT["MAPT"]
    MAPT -->|"associated with"| DYNEIN
    DNA["DNA"]
    DNA -->|"interacts with"| DYNEIN
    A2M["A2M"]
    A2M -->|"interacts with"| DYNEIN
    APOE["APOE"]
    APOE -->|"interacts with"| DYNEIN
    PSEN2["PSEN2"]
    PSEN2 -->|"interacts with"| DYNEIN
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"interacts with"| DYNEIN
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"interacts with"| DYNEIN
    style DYNEIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (163)

Target	Relation	Type	Str
Huntington	regulates	disease	0.65
Als	activates	disease	0.65
Parkinson	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	transports	disease	0.65
Infection	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Bipolar	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	causes	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Als	causes	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Neuropathy	transports	disease	0.65
ALS	regulates	disease	0.65
Huntington	transports	disease	0.65
Alzheimer	expressed_in	disease	0.65
REELIN	causes	gene	0.60
PSEN1	interacts_with	gene	0.60
MAPT	associated_with	gene	0.60
DAB1	causes	gene	0.60
APH1B	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
Fus	contributes_to	protein	0.60
TNF	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
PAFAH1B1	causes	gene	0.60
A2M	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Raf	interacts_with	protein	0.60
IL6	interacts_with	gene	0.60
DCX	causes	gene	0.60
MAPT	interacts_with	entity	0.60
EIF2AK2	interacts_with	gene	0.60
Dynein	associated_with	protein	0.60
CDK5	causes	gene	0.60
HMGCR	interacts_with	gene	0.60
LIS1	interacts_with	entity	0.60
OPA1	expressed_in	gene	0.60
POLE	interacts_with	gene	0.60
HDAC6	associated_with	gene	0.60

Incoming (140)

Source	Relation	Type	Str
TRAK2	interacts_with	protein	0.95
TRAK1	binds	protein	0.95
NEURON	causes	gene	0.60
DNA	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
AXON	interacts_with	gene	0.60
NEURON	transports	gene	0.60
TRAK1	interacts_with	gene	0.60
AXON	causes	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
TRAK1	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
MITOCHONDRIA	activates	gene	0.60
GFP	expressed_in	gene	0.60
ATP	expressed_in	gene	0.60
SYNAPSE	expressed_in	gene	0.60
PINK1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
A2M	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
DHCR24	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
HMGCR	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
DYNACTIN	interacts_with	gene	0.60
MITOCHONDRIA	transports	gene	0.60
TAU	activates	gene	0.60
DNAJB6	regulates	gene	0.60
DYNACTIN	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DYNEIN in their description or question text

No additional research found