gene

DVL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DVL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

6Outgoing

5Incoming

0Experiments

0Debates

Summary

DVL2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in. Associated with Inflammation, Ms. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DVL2
Full Name	Dishevelled Segment Polarity Protein 2
Chromosome	17p13.1
Protein Type	Scaffold Protein
Function	Wnt signaling: Central mediator of canonical and non-canonical Wnt pathways
Molecular Weight	82 kDa
Amino Acids	740 aa
Exons	15
Pathways	Wnt
GeneCards	DVL2
Human Protein Atlas	DVL2
Synapse Formation	DVL2 regulates the formation of excitatory synapses by promoting postsynaptic density protein 95 (PSD-95) clustering and recruiting AMPA-type glutamate receptors to synaptic sites [11].
Synaptic Plasticity	Through its interactions with CaMKII and other synaptic proteins, DVL2 contributes to long-term potentiation (LTP) and long-term depression (LTD), cellular correlates of learning and memory [1].
Axon Guidance	DVL2 mediates guidance cue responses that direct neuronal axons to their correct targets during development and regeneration [4].
Highest Expression	Cerebral cortex, hippocampus, and cerebellum show the highest DVL2 expression levels throughout life [1].
Associated Diseases	neurodegeneration
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DVL2 — Dishevelled Segment Polarity Protein 2

gene · 2335 words

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Pathway Diagram

graph TD
    DVL2["DVL2"]
    Ms{"Ms"}
    DVL2 -->|"therapeutic target"| Ms
    Inflammation{"Inflammation"}
    DVL2 -->|"therapeutic target"| Inflammation
    P38["P38"]
    DVL2 -->|"therapeutic target"| P38
    STAT6["STAT6"]
    DVL2 -->|"therapeutic target"| STAT6
    Akt(["Akt"])
    DVL2 -->|"therapeutic target"| Akt
    Mtor(["Mtor"])
    DVL2 -->|"therapeutic target"| Mtor
    neurodegeneration["neurodegeneration"]
    DVL2 -->|"implicated in"| neurodegeneration
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| DVL2
    ERK["ERK"]
    ERK -->|"therapeutic target"| DVL2
    AKT["AKT"]
    AKT -->|"therapeutic target"| DVL2
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic target"| DVL2
    style DVL2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Akt	therapeutic_target	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
P38	therapeutic_target	gene	0.60
STAT6	therapeutic_target	gene	0.60

Incoming (5)

Source	Relation	Type	Str
MTOR	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
DCX	expressed_in	gene	0.60
ERK	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DVL2 in their description or question text

No additional research found