gene

SMAD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

33Outgoing

14Incoming

0Experiments

0Debates

Summary

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🧬 Gene Info

Gene Symbol	SMAD1
Full Name	SMAD Family Member 1
Chromosome	4q31.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the central nervous system:
Amino Acids	493 aa
Pathways	TGF-β, signaling: [@liu2006]
UniProt ID	Q99707
NCBI Gene ID	4093
Ensembl ID	ENSG00000147853
OMIM	601595
GeneCards	SMAD1
Human Protein Atlas	SMAD1
MH1 domain (N-terminal)	DNA-binding region that binds to specific DNA sequences (SBE - SMAD-binding element)
MH2 domain (C-terminal)	Protein-protein interaction domain that mediates interactions with receptors, co-SMADs, and transcriptional co-activators/repressors
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APP, APP/PS1, AXON
KG Connections	47 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD1 — AlphaFold Q99707 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMAD1 Gene

gene · 615 words

→

SMAD1 Protein

protein · 724 words

→

Pathway Diagram

graph TD
    SMAD1["SMAD1"]
    BMPR1A["BMPR1A"]
    BMPR1A -->|"activates"| SMAD1
    Neuroinflammation["Neuroinflammation"]
    SMAD1 -->|"activates"| Neuroinflammation
    Inflammation["Inflammation"]
    SMAD1 -->|"activates"| Inflammation
    Alzheimer["Alzheimer"]
    SMAD1 -->|"activates"| Alzheimer
    EPHA10["EPHA10"]
    SMAD1 -->|"activates"| EPHA10
    EGF["EGF"]
    SMAD1 -->|"activates"| EGF
    Oxidative_Stress["Oxidative Stress"]
    SMAD1 -->|"activates"| Oxidative_Stress
    Epigenetic["Epigenetic"]
    SMAD1 -->|"activates"| Epigenetic
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    SMAD1 -->|"activates"| OXIDATIVE_STRESS
    AXON["AXON"]
    SMAD1 -->|"activates"| AXON
    AND["AND"]
    SMAD1 -->|"activates"| AND
    PROTEIN_MISFOLDING["PROTEIN MISFOLDING"]
    SMAD1 -->|"activates"| PROTEIN_MISFOLDING
    ALZHEIMER["ALZHEIMER"]
    SMAD1 -->|"activates"| ALZHEIMER
    GFAP["GFAP"]
    SMAD1 -->|"activates"| GFAP
    APP["APP"]
    SMAD1 -->|"activates"| APP
    PRESENILIN["PRESENILIN"]
    SMAD1 -->|"activates"| PRESENILIN
    ROS["ROS"]
    SMAD1 -->|"activates"| ROS
    DCX["DCX"]
    SMAD1 -->|"activates"| DCX
    SMAD2["SMAD2"]
    SMAD1 -->|"activates"| SMAD2
    APP_PS1["APP/PS1"]
    SMAD1 -->|"activates"| APP_PS1
    SMAD4["SMAD4"]
    SMAD1 -->|"activates"| SMAD4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SMAD1 -->|"activates"| ALZHEIMER_S_DISEASE
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    SMAD1 -->|"activates"| NEURODEGENERATIVE_DISEASES
    AMYLOID["AMYLOID"]
    SMAD1 -->|"activates"| AMYLOID
    Amyloid["Amyloid"]
    SMAD1 -->|"activates"| Amyloid
    Neurogenesis["Neurogenesis"]
    SMAD1 -->|"activates"| Neurogenesis
    AXON["AXON"]
    AXON -->|"activates"| SMAD1
    GENES["GENES"]
    GENES -->|"activates"| SMAD1
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| SMAD1
    TUBULIN["TUBULIN"]
    TUBULIN -->|"activates"| SMAD1

Outgoing (33)

Target	Relation	Type	Str
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
PROTEIN MISFOLDING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PRESENILIN	activates	gene	0.60
ROS	activates	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
Neurogenesis	activates	pathway	0.60
TGF-beta signaling	participates_in	pathway	0.60
AXON	activates	gene	0.60
frontotemporal dementia	activates	disease	0.60
OXIDATIVE STRESS	activates	gene	0.60
GFAP	activates	gene	0.60
APP	activates	gene	0.60
DCX	activates	gene	0.60
SMAD2	activates	gene	0.60
SMAD4	activates	gene	0.60
EGF	activates	gene	0.60
SMAD4	associated_with	gene	0.60
TET2	associated_with	gene	0.60
Epigenetic	activates	pathway	0.60
EPHA10	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Neuron	expressed_in	cell_type	0.55
Dentate Gyrus	expressed_in	brain_region	0.55
Reactive Oxygen Species	activates	process	0.50
SMAD	activates	protein	0.50
TUBULIN	activates	protein	0.50

Incoming (14)

Source	Relation	Type	Str
PIF	upregulates	protein	0.95
BMPR1A	activates	gene	0.80
ABCC8	associated_with	gene	0.60
AQP1	associated_with	gene	0.60
BMPR1A	associated_with	gene	0.60
BMPR1B	associated_with	gene	0.60
NOTCH3	associated_with	gene	0.60
GENES	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
EPHA10	activates	gene	0.60
TUBULIN	activates	gene	0.60
AXON	activates	gene	0.60
GFAP	activates	gene	0.50
TDC	associated_with	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMAD1 in their description or question text

No additional research found