concept

MAMS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAMS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name

MAMS

Pathway Diagram

graph TD
    MAMS[MAMS]
    MAMS -->|mediates| calcium_signaling[calcium signaling]
    MAMS -->|drives| Alzheimer_s_Disease[Alzheimer's Disease]
    MAMS -->|regulates| mitochondrial_dynamics[mitochondrial dynamics]
    MAMS -->|drives| Parkinson_s_Disease[Parkinson's Disease]
    MAMS -->|involved_in| autophagy[autophagy]
    MAMS -->|regulates| APP[APP]
    MAMS -->|involved_in| mitophagy[mitophagy]
    MAMS -->|implicated in| metabolic_disorders[metabolic disorders]
    MAMS -->|contributes to| cancer_progression[cancer progression]
    IP3R[IP3R] -->|involved_in| MAMS
    VDAC1[VDAC1] -->|involved_in| MAMS
    SIGMAR1[SIGMAR1] -->|regulates| MAMS

Outgoing (10)

Target	Relation	Type	Str
Alzheimer's Disease	drives	disease	0.90
calcium signaling	mediates	process	0.90
Parkinson's Disease	drives	disease	0.85
mitochondrial dynamics	regulates	process	0.85
lipid synthesis	associated_with	process	0.85
mitophagy	involved_in	process	0.80
autophagy	involved_in	process	0.80
APP	regulates	gene	0.80
metabolic disorders	implicated_in	disease	0.75
cancer progression	contributes_to	process	0.70

Incoming (4)

Source	Relation	Type	Str
IP3R	involved_in	protein	0.95
VDAC1	involved_in	protein	0.95
SIGMAR1	regulates	gene	0.85
SNCA	associated_with	gene	0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync	0.615	neurodegeneration	How do different organelle-specific auto

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAMS in their description or question text

No additional research found