protein

NEUROGRANIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROGRANIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

4Hypotheses

0Analyses

38Outgoing

25Incoming

0Experiments

0Debates

Summary

NEUROGRANIN is a protein involved in neurodegeneration research. Key relationships include: biomarker for, implicated in, expressed in. Associated with ALS, Aging, Alzheimer. Connected to 17 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NEUROGRANIN
Function	Neurogranin is essential for synaptic plasticity through
Pathways	Calcium signaling, Amyloid, Blood-Brain Barrier
GeneCards	NEUROGRANIN
Human Protein Atlas	NEUROGRANIN
Cognitive Decline	Higher CSF Ng predicts faster cognitive decline
Synaptic Loss	Correlates with synaptic protein loss in AD brain
Disease Progression	Increases with disease severity
Diagnostic Utility	Helps differentiate AD from other dementias
Synaptic Protection	Strategies to preserve synaptic integrity may lower CSF Ng
Drug Development	Ng levels used as biomarker in clinical trials
Patient Stratification	High CSF Ng identifies patients with active synaptic loss
Associated Diseases	Als, Alzheimer, Neuroinflammation
Interactions	BDNF
KG Connections	61 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neurogranin (Ng) - Synaptic Biomarker

biomarker · 965 words

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Pathway Diagram

graph TD
    NEUROGRANIN["NEUROGRANIN"]
    Neuroinflammation{"Neuroinflammation"}
    NEUROGRANIN -->|"biomarker for"| Neuroinflammation
    Aging{"Aging"}
    NEUROGRANIN -->|"biomarker for"| Aging
    Inflammation{"Inflammation"}
    NEUROGRANIN -->|"biomarker for"| Inflammation
    Alzheimer{"Alzheimer"}
    NEUROGRANIN -->|"biomarker for"| Alzheimer
    ALS{"ALS"}
    NEUROGRANIN -->|"biomarker for"| ALS
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROGRANIN -->|"biomarker for"| NEUROINFLAMMATION
    TAU["TAU"]
    NEUROGRANIN -->|"biomarker for"| TAU
    Amyloid(["Amyloid"])
    NEUROGRANIN -->|"biomarker for"| Amyloid
    AMYLOID["AMYLOID"]
    NEUROGRANIN -->|"biomarker for"| AMYLOID
    Neuron["Neuron"]
    NEUROGRANIN -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    NEUROGRANIN -->|"implicated in"| neurodegeneration
    AMYLOID -->|"biomarker for"| NEUROGRANIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| NEUROGRANIN
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"biomarker for"| NEUROGRANIN
    NFL["NFL"]
    NFL -->|"biomarker for"| NEUROGRANIN
    BACE1["BACE1"]
    BACE1 -->|"biomarker for"| NEUROGRANIN
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    SYNAPTOPHYSIN -->|"biomarker for"| NEUROGRANIN
    AND["AND"]
    AND -->|"biomarker for"| NEUROGRANIN
    style NEUROGRANIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
BDNF	interacts_with	protein	0.85
Calcium signaling	activates	pathway	0.80
Synaptic Dysfunction	biomarker_for	mechanism	0.80
Neuroinflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neuron	therapeutic_target	cell_type	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
Amyloid	biomarker_for	pathway	0.60
BACE1	biomarker_for	gene	0.60
Pericyte	associated_with	cell_type	0.60
Endothelial	associated_with	cell_type	0.60
Aβ	associated_with	protein	0.60
Albumin	associated_with	protein	0.60
SYNAPTOPHYSIN	biomarker_for	entity	0.60
Α-Synuclein	associated_with	protein	0.60
ALZHEIMER	biomarker_for	gene	0.60
Neuron	biomarker_for	cell_type	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
NFL	biomarker_for	gene	0.60
Α-Synuclein	biomarker_for	protein	0.60
TAU	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
Aβ	biomarker_for	protein	0.60
Tau Protein	biomarker_for	protein	0.60
TREM2	biomarker_for	gene	0.60
SIGMA1	therapeutic_target	gene	0.60
Neuron	expressed_in	cell_type	0.55
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50

Incoming (25)

Source	Relation	Type	Str
NEUROG1	associated_with	gene	0.90
ALZHEIMER	therapeutic_target	gene	0.60
TAU	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
SIGMA1	biomarker_for	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PERICYTE	associated_with	gene	0.60
BACE1	biomarker_for	gene	0.60
SYNAPTOPHYSIN	biomarker_for	gene	0.60
TREM2	biomarker_for	gene	0.60
SIGMA1	therapeutic_target	gene	0.60
TAU	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
NFL	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
YKL-40	associated_with	protein	0.50
NEUROFILAMENT LIGHT CHAIN	associated_with	protein	0.50
Neuroinflammation	associated_with	process	0.50
SYNAPTOPHYSIN	associated_with	gene	0.50
BACE1	associated_with	gene	0.50
SNAP-25	associated_with	protein	0.50
TREM2	associated_with	gene	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.757	biomarkers	What biomarkers can reliably detect micr
Neurogranin Co-Normalization Validates p-tau217 as a Surroga	0.415	-	Can CSF p-tau217 normalization serve as
Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining	0.389	biomarkers	What biomarkers can reliably detect micr
Dynamic Blood-Based Exosome Panel for Real-Time Neuroinflamm	0.380	biomarkers	What biomarkers can reliably detect micr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUROGRANIN in their description or question text

No additional research found