cell_type

NEUTROPHIL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUTROPHIL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

422Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧫 Cell Type Info

Cell Type	NEUTROPHIL
Related Genes	AKT, APOE, APOE4, MAPK
Linked Hypotheses	33 hypotheses

Pathway Diagram

graph TD
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| T_CELL["T CELL"]
    style T_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| T_CELLS["T CELLS"]
    style T_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"treats"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"increases"| SPINAL_CORD["SPINAL CORD"]
    style SPINAL_CORD fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"causes"| LUNG_INFLAMMATION["LUNG_INFLAMMATION"]
    style LUNG_INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"regulates"| NRF2["NRF2"]
    style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEUTROPHIL["NEUTROPHIL"] -->|"activates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    AGING["AGING"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style AGING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    APOE["APOE"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APOE4["APOE4"] -->|"interacts"| NEUTROPHIL["NEUTROPHIL"]
    style APOE4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MICROGLIA["MICROGLIA"] -->|"expressed in"| NEUTROPHIL["NEUTROPHIL"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    B_CELL["B CELL"] -->|"increases"| NEUTROPHIL["NEUTROPHIL"]
    style B_CELL fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEUTROPHIL fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (53)

Target	Relation	Type	Str
COPD Lung Tissue	upregulates	phenotype	0.88
Skeletal Muscle Inflammation	mediates	disease	0.85
SPINAL CORD	increases	brain_region	0.65
PI3K	treats	gene	0.65
T CELL	increases	cell_type	0.65
T CELLS	increases	cell_type	0.65
SPINAL CORD	inhibits	brain_region	0.65
ROS	activates	gene	0.65
T CELL	contributes_to	cell_type	0.65
LUNG_INFLAMMATION	causes	phenotype	0.64
TBI	associated_with	disease	0.60
TBI	causes	disease	0.60
STROKE	interacts_with	disease	0.60
NLRP3	activates	gene	0.60
TBI	mediates	disease	0.60
SIRT6	exacerbates	gene	0.60
TNF	activates	gene	0.60
TUMOR	activates	disease	0.60
SPINAL CORD	impairs	brain_region	0.60
NRF2	regulates	gene	0.60
Pain	interacts_with	disease	0.50
IL-1	activates	concept	0.50
Brainstem	expressed_in	brain_region	0.50
NEUTROPHILS	expressed_in	concept	0.50
IL-17	expressed_in	concept	0.50
Cortex	expressed_in	brain_region	0.50
NEUTROPHILS	inhibits	concept	0.50
NEUTROPHILS	interacts_with	concept	0.50
MAPK SIGNALING	associated_with	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
FIBROBLASTS	activates	concept	0.50
B CELLS	activates	concept	0.50
SPINAL CORD INJURY	inhibits	concept	0.50
NEUTROPHILS	associated_with	concept	0.50
SPINAL CORD INJURY	associated_with	concept	0.50
NUCLEUS	regulates	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
NEUTROPHILS	regulates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
Spinal Cord	expressed_in	brain_region	0.50
Thalamus	expressed_in	brain_region	0.50
Hypothalamus	expressed_in	brain_region	0.50
NEUTROPHILS	activates	concept	0.50
IL-17	activates	concept	0.50
SPINAL CORD	co_discussed	brain_region	0.40
TLR4	co_discussed	gene	0.40
PI3K	co_discussed	gene	0.40
T CELL	co_discussed	cell_type	0.40
STROKE	co_discussed	disease	0.40
T CELLS	co_discussed	cell_type	0.40

Incoming (369)

Source	Relation	Type	Str
IL17	expressed_in	pathway	0.90
macrophage	associated_with	cell_type	0.85
Anti-Il-17 Antibody	suppresses	drug	0.75
MICROGLIA	expressed_in	cell_type	0.65
MONOCYTES	accumulates_in	cell_type	0.65
MONOCYTE	interacts_with	cell_type	0.65
AKT	treats	gene	0.65
MAST CELL	contributes_to	cell_type	0.65
APOE	interacts_with	gene	0.65
APOE4	interacts_with	gene	0.65
MONOCYTE	accumulates_in	cell_type	0.65
MACROPHAGE	increases	cell_type	0.65
MAPK	treats	gene	0.65
B CELL	increases	cell_type	0.65
ENDOTHELIAL	increases	cell_type	0.65
APOE	expressed_in	gene	0.65
MENINGITIS	accumulates_in	disease	0.65
MONOCYTES	interacts_with	cell_type	0.65
MACROPHAGES	associated_with	cell_type	0.65
DNA	activates	gene	0.60
EXERCISE	activates	gene	0.60
PDGFB	activates	gene	0.60
MERTK	activates	gene	0.60
PDGF	activates	gene	0.60
IBA1	activates	gene	0.60
APOE	impairs	gene	0.60
MICROGLIA	impairs	cell_type	0.60
ROS	activates	gene	0.60
S100A9	activates	gene	0.60
PAD4	inhibits	gene	0.60
SMPD1	contributes_to	gene	0.60
NAIP	causes	gene	0.60
APOPTOSIS	causes	gene	0.60
NLRP3	causes	gene	0.60
NLR	causes	gene	0.60
CYTOKINES	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
TREM2	activates	gene	0.60
S100A8	activates	gene	0.60
ARG1	activates	gene	0.60
IL-10	activates	gene	0.60
CHI3L1	activates	gene	0.60
MMP9	activates	gene	0.60
LCN2	activates	gene	0.60
HBB	activates	gene	0.60
IL-18	expressed_in	gene	0.60
ERBB2	activates	gene	0.60
PD-L1	activates	gene	0.60
HBA1	activates	gene	0.60
PARK2	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neutrophil Extracellular Trap (NET) Inhibition	0.806	-	Blood-brain barrier tight junction disru
NETosis Amplification by C1Q in Plaque Neutrophils	0.500	neuroinflammation	What are the specific molecular mechanis

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (6)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Neutrophil extracellular traps in central nervous system disorders: mechanisms, [PMID:40469282]	Qiao S, Yuan J, Zhang SC	Front Immunol	2025
NETosis in Alzheimer's Disease: Understanding the Role of Neutrophil Extracellul [PMID:41460435]	Rao R, Verma H, Gangwar P	Mol Neurobiol	2025
Integrating network pharmacology and transcriptomic omics reveals that akebia sa [PMID:38149910]	Gu L, Ye L, Chen Y	FASEB J	2024
Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extra [PMID:37500363]	Chou ML, Babamale AO, Walker TL	Trends Neurosci	2023
Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neuro [PMID:37550658]	Kunze R, Fischer S, Marti HH	J Biomed Sci	2023
NETosis in Alzheimer's Disease. [PMID:28303140]	Pietronigro EC, Della Bianca V, Zenaro E	Front Immunol	2017

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NEUTROPHIL in their description or question text

No additional research found