gene

PKC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PKC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PKC is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 267 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PKC
Full Name	Protein Kinase C Alpha
Chromosome	17q24.2
Protein Family	PKC (Protein Kinase C) family
Amino Acids	672 aa
Exons	17
Pathways	Akt, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID	[P17252](https://www.uniprot.org/uniprot/P17252)
Ensembl ID	ENSG00000154229
OMIM	176960
GeneCards	PKC
Human Protein Atlas	PKC
Associated Diseases	Als, Alzheimer, Ataxia, Diabetes, Ms
Known Drugs/Compounds	metformin
Interactions	AGING, AKT, ALOX5, AMPK, Amyloid, AMYLOID
KG Connections	528 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PKC["PKC
(Protein Kinase C)"]
    
    JUN["JUN
(Transcription Factor)"]
    MTORC2["mTORC2
(mTOR Complex 2)"]
    
    NRF2["NRF2
(Antioxidant Response)"]
    KEAP1["KEAP1
(NRF2 Regulator)"]
    
    TNF["TNF
(Tumor Necrosis Factor)"]
    Inflammation["Inflammation
(Neuroinflammation)"]
    
    AKT["AKT Pathway
(Cell Survival)"]
    MAPK["MAPK Pathway
(Cell Signaling)"]
    PI3K["PI3K Pathway
(Growth Signaling)"]
    
    Apoptosis["Apoptosis
(Cell Death)"]
    
    ALS["ALS
(Amyotrophic Lateral
Sclerosis)"]
    MS["Multiple Sclerosis
(Demyelinating Disease)"]
    Ataxia["Ataxia
(Movement Disorder)"]
    Neurodegeneration["Neurodegeneration
(Neural Loss)"]
    
    JUN -->|"regulates"| PKC
    MTORC2 -->|"activates"| PKC
    
    PKC -->|"activates"| NRF2
    PKC -->|"activates"| KEAP1
    PKC -->|"activates"| TNF
    PKC -->|"activates"| AKT
    PKC -->|"activates"| MAPK
    PKC -->|"activates"| PI3K
    PKC -->|"activates"| Apoptosis
    
    TNF -->|"promotes"| Inflammation
    
    PKC -->|"therapeutic target"| ALS
    PKC -->|"inhibits"| MS
    PKC -->|"associated with"| Ataxia
    PKC -->|"associated with"| Neurodegeneration
    
    Inflammation -->|"contributes to"| Neurodegeneration
    Apoptosis -->|"leads to"| Neurodegeneration
    
    style PKC fill:#006494
    style NRF2 fill:#1b5e20
    style AKT fill:#1b5e20
    style JUN fill:#4a1a6b
    style MTORC2 fill:#4a1a6b
    style TNF fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style Ataxia fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (358)

Target	Relation	Type	Str
Als	regulates	disease	0.95
Als	activates	disease	0.95
PI3K	activates	gene	0.90
AKT	activates	gene	0.90
Mapk	activates	pathway	0.90
Cancer	regulates	disease	0.85
calcium signaling	participates_in	pathway	0.85
AMPK	interacts_with	protein	0.85
Cancer	activates	disease	0.85
NRF2	phosphorylates	protein	0.85
Alzheimer	therapeutic_target	disease	0.85
ERK	activates	gene	0.80
CANCER	activates	gene	0.80
Dementia	therapeutic_target	disease	0.75
Apoptosis	regulates	pathway	0.70
BCL-2	activates	gene	0.70
OVERVIEW	regulates	gene	0.70
DEMENTIA	therapeutic_target	gene	0.70
RAS	activates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
CANCER	regulates	gene	0.70
GENES	activates	gene	0.70
MTORC1	regulates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
Nf-Κb	contributes_to	pathway	0.70
Nf-Κb	activates	pathway	0.70
MITOCHONDRIA	activates	gene	0.70
Ms	inhibits	disease	0.65
Dementia	activates	disease	0.65
Lymphoma	activates	disease	0.65
Als	inhibits	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Depression	contributes_to	disease	0.65
Diabetes	regulates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Anxiety	activates	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Addiction	therapeutic_target	disease	0.65
Als	causes	disease	0.65
Alzheimer	causes	disease	0.65
Retinopathy	contributes_to	disease	0.65
Ferroptosis	protects_against	disease	0.65
Stroke	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	protects_against	disease	0.65

Incoming (170)

Source	Relation	Type	Str
MTORC2	phosphorylates	protein	0.90
JUN	regulates	protein	0.80
EIF2B3	participates_in	gene	0.80
MTORC2	activates	protein	0.72
PI3K	associated_with	gene	0.70
TAU	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
AQP4	activates	gene	0.65
CREB	activates	gene	0.65
ALOX5	interacts_with	gene	0.60
LRRN1	regulates	gene	0.60
SMPD1	regulates	gene	0.60
SORL1	interacts_with	gene	0.60
APP	inhibits	gene	0.60
P38	associated_with	gene	0.60
HO1	therapeutic_target	gene	0.60
NRF2	contributes_to	gene	0.60
PI3K	therapeutic_target	gene	0.60
SORLA	activates	gene	0.60
NLRP3	protects_against	gene	0.60
CHAT	associated_with	gene	0.60
GFAP	associated_with	gene	0.60
TLR4	activates	gene	0.60
ERK1	associated_with	gene	0.60
RHOA	activates	gene	0.60
PIK3CA	inhibits	gene	0.60
JNK	activates	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
NRF1	activates	gene	0.60
MMP9	activates	gene	0.60
MMP1	activates	gene	0.60
BAX	activates	gene	0.60
TLR3	contributes_to	gene	0.60
BDNF	contributes_to	gene	0.60
TRKB	contributes_to	gene	0.60
NOTCH1	activates	gene	0.60
GAIN	activates	gene	0.60
OVERVIEW	regulates	gene	0.60
AKT	inhibits	gene	0.60
AKT	phosphorylates	gene	0.60
APP	phosphorylates	gene	0.60
ATM	associated_with	gene	0.60
CD86	activates	gene	0.60
EGR1	activates	gene	0.60
GENES	associated_with	gene	0.60
ERK	activates	gene	0.60
GENES	activates	gene	0.60
ANTIOXIDANT GENES	activates	gene	0.60
GENES	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PKC in their description or question text

No additional research found

PKC