gene

TYRO3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYRO3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

1Hypotheses

1Analyses

11Outgoing

7Incoming

0Experiments

1Debates

Summary

TYRO3 Receptor Tyrosine Kinase: founding member of TAM family with critical roles in neuronal survival, synaptic function, and myelination

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🧬 Gene Info

Gene Symbol	TYRO3
Full Name	TYRO3 - TYRO3 Receptor Tyrosine Kinase
Aliases	Page for TYRO3 Protein
Chromosome	15q15.2
Protein Type	Gene
Primary Expression	neurons, oligodendrocytes, and to a lesser extent in microglia, where it mediates cell survival, migration, and immune regulation through activation o
Molecular Weight	140 kDa
Amino Acids	903 aa
Exons	22
Pathways	NF-κB, PI3K, MAPK
UniProt ID	Q06418
NCBI Gene ID	7304
Ensembl ID	ENSG00000092470
GeneCards	TYRO3
Human Protein Atlas	TYRO3
Associated Diseases	Aging, Diabetes, Ferroptosis, neuroinflammation
SciDEX Hypotheses	TYRO3-STAT1 Axis to Preserve Parvalbumin Interneur
KG Connections	18 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TYRO3 — AlphaFold Q06418 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TYRO3 - TYRO3 Receptor Tyrosine Kinase

gene · 2468 words

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Pathway Diagram

graph TD
    TYRO3["TYRO3"]
    TYRO3 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    TYRO3 ---|"associated"| Ferroptosis["Ferroptosis"]
    TYRO3 ---|"associated"| Aging["Aging"]
    TYRO3 ---|"associated"| Diabetes["Diabetes"]
    TYRO3 ---|"associated"| SREBF1["SREBF1"]
    TYRO3 ---|"associated"| CAMKK2["CAMKK2"]
    FURIN["FURIN"] ---|"associated"| TYRO3
    STAT3["STAT3"] ---|"associated"| TYRO3
    KDM5A["KDM5A"] ---|"associated"| TYRO3
    COMPLEMENT["COMPLEMENT"] ---|"associated"| TYRO3
    RNA["RNA"] ---|"associated"| TYRO3

Outgoing (11)

Target	Relation	Type	Str
Ferroptosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
ARNTL	associated_with	gene	0.60
CAMKK2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
tam_receptor_tyrosine_kinase_signaling	involved_in	pathway	0.40
neuroinflammation	associated_with	disease	0.40
STAT1	co_associated_with	gene	0.30

Incoming (7)

Source	Relation	Type	Str
FURIN	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
KDM5A	associated_with	gene	0.60
h-315367de	targets	hypothesis	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TYRO3-STAT1 Axis to Preserve Parvalbumin Interneuron Functio	0.506	neuroinflammation	Why do TAM receptors protect against neu

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

closed · Rounds: 4 · Score: 0.75 · 2026-04-15

Related Research

Hypotheses and analyses mentioning TYRO3 in their description or question text

No additional research found