gene 2,340 words KG: CTSB
Contents

CTSB Gene

🧬 Gene Info
Gene SymbolCTSB
Full NameCathepsin B
Chromosome8p23.1
Subcellular Localization| Compartment | Function |
Molecular Weight26 kDa
Amino Acids339 aa
Exons13
PathwaysAutophagy
UniProt IDP07846
NCBI Gene ID1508
Ensembl IDENSG00000164733
OMIM116810
GeneCardsCTSB
Human Protein AtlasCTSB
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, APOPTOSIS
Known Drugs/Compoundsrapamycin, tannic acid
InteractionsACTB, Actin, AGING, AIF1, AKT, ALS
SciDEX HypothesesSelective cathepsin B inhibition prevents cathepsi
KG Connections816 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
APOE-Dependent Autophagy Restoration
Score: 0.85
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79

Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSB activates C1QA
CTSB activates SPP1
CTSB activates GRN
STIP1 associated_with CTSB
LGALS3 associated_with CTSB
HSPA8 associated_with CTSB
MCOLN1 associated_with CTSB
SQSTM1 associated_with CTSB
SOD1 associated_with CTSB
BCL2 associated_with CTSB

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