protein

KDM5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

34Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for KDM5A Protein (Lysine Specific Demethylase 5A (JARID1A))

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🔬 Protein Info

Gene Symbol	KDM5A
Full Name	Lysine Specific Demethylase 5A
Aliases	Lysine Specific Demethylase 5A (JARID1A
Chromosome	12p13.33
Protein Family	JARID1 family (Jumonji C domain demethylase)
Function	This activity positions KDM5A as a transcriptional repressor that silences gene expression programs [[klose2006]](https://pubmed.ncbi.nlm.nih.gov/17110336/).
Pathways	Developmental Gene Regulation, Developmental Regulation
UniProt ID	Q9UMM3
NCBI Gene ID	8248
Ensembl ID	ENSG00000150109
OMIM	180388
GeneCards	KDM5A
Human Protein Atlas	KDM5A
H3K9me2/me3 demethylation	KDM5A can also target H3K9 methylation marks, which are typically associated with gene silencing, thereby modulating chromatin accessibility [[iwase2007]](https://pubmed.ncbi.nlm.nih.gov/17634180/).
Response to cellular stress	KDM5A participates in neuronal stress responses by regulating genes involved in apoptosis, DNA repair, and protein quality control [[zhang2016]](https://pubmed.ncbi.nlm.nih.gov/26630756/).
Associated Diseases	Aging, ALS, Diabetes, Ferroptosis
Interactions	AND, CHD4, NURD COMPLEX, PARP1
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KDM5A — AlphaFold Q9UMM3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDM5A (Lysine Specific Demethylase 5A)

gene · 1307 words

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KDM5A Protein (Lysine Specific Demethylase 5A (JARID1A))

protein · 623 words

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Pathway Diagram

graph TD
    KDM5A["KDM5A"]
    TREM2["TREM2"]
    KDM5A -->|"upregulates"| TREM2
    HOXA5["HOXA5"]
    KDM5A -->|"regulates"| HOXA5
    Wnt___catenin_pathway(["Wnt/beta-catenin pathway"])
    KDM5A -->|"activates"| Wnt___catenin_pathway
    KDM5A -->|"inhibits"| Wnt___catenin_pathway
    p53["p53"]
    KDM5A -->|"regulates"| p53
    WTAP["WTAP"]
    KDM5A -->|"upregulates"| WTAP
    PARP1["PARP1"]
    KDM5A -->|"interacts with"| PARP1
    Als{"Als"}
    KDM5A -->|"regulates"| Als
    ALS{"ALS"}
    KDM5A -->|"regulates"| ALS
    CHD4["CHD4"]
    KDM5A -->|"regulates"| CHD4
    GENES["GENES"]
    KDM5A -->|"regulates"| GENES
    AND["AND"]
    KDM5A -->|"interacts with"| AND
    microglia["microglia"]
    microglia -->|"regulates"| KDM5A
    CHD4 -->|"regulates"| KDM5A
    GENES -->|"regulates"| KDM5A
    style KDM5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
H3K4 Methylation	catalyzes	entity	0.95
NURD COMPLEX	interacts_with	protein	0.95
Developmental Regulation	involved_in	process	0.90
Transcriptional Activation	regulates	process	0.85
CHD4	interacts_with	protein	0.85
Developmental Gene Regulation	involved_in	process	0.85
WTAP	upregulates	gene	0.80
TREM2	upregulates	gene	0.80
HOXA5	regulates	gene	0.80
Wnt/β-catenin pathway	activates	pathway	0.80
Wnt/β-catenin pathway	inhibits	pathway	0.80
p53	regulates	protein	0.80
PARP1	interacts_with	protein	0.80
Diabetes	associated_with	disease	0.65
ALS	regulates	disease	0.65
Ferroptosis	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	regulates	disease	0.65
CAMKK2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
CHD4	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
TYRO3	associated_with	gene	0.60
SREBF1	associated_with	gene	0.60
AND	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
RNA	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
GENES	regulates	gene	0.60
Rb	regulates	protein	0.60
COMPLEMENT	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
microglia	regulates	cell_type	0.70
GENES	regulates	gene	0.60
FURIN	associated_with	gene	0.60
CHD4	regulates	gene	0.60
STAT3	associated_with	gene	0.60
CHD4	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM5A in their description or question text

No additional research found