gene

CSF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	CSF2
Full Name	Colony Stimulating Factor 2 (GM-CSF)
Chromosome	5q31.1
Function	is a cytokine-encoding gene located on chromosome 5q31.
Primary Expression	various brain cell types including neurons, astrocytes, [microglia](/cell-types/microglia-neuroinflammati
Molecular Weight	14 kDa
Amino Acids	17 aa
Exons	4
Pathways	Akt, IMMUNE_RESPONSE, Mapk, Pi3K, Pi3K/Akt
UniProt ID	[P04141](https://www.uniprot.org/uniprot/P04141)
Ensembl ID	ENSG00000164400
OMIM	138960
GeneCards	CSF2
Human Protein Atlas	CSF2
Macrophages and Monocytes	Primary cellular sources
Associated Diseases	neurodegeneration
Interactions	App, CYTOKINES, EXOSOMES, Il-1, IL-1, IL1A
KG Connections	156 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CSF2 — Colony Stimulating Factor 2 (GM-CSF)

gene · 1300 words

→

CSF2RA — Colony Stimulating Factor 2 Receptor Alpha Chain

gene · 1774 words

→

Pathway Diagram

graph TD
    CSF2["CSF2 (GM-CSF)"]
    CSF2RA["CSF2RA Receptor"]
    Pi3K_Akt["PI3K/AKT Pathway"]
    MAPK["MAPK Pathway"]
    STAT1["STAT1"]
    TLR4["TLR4"]
    CXCL10["CXCL10"]
    S100A8["S100A8"]
    FGF2["FGF2"]
    Inflammation["Neuroinflammation"]
    ALS["ALS"]
    MS["Multiple Sclerosis"]
    Microglia["Microglial Activation"]
    Neuroprotection["Neuroprotection"]
    Neurodegeneration["Neurodegeneration"]

    CSF2 -->|"binds to"| CSF2RA
    CSF2RA -->|"activates"| Pi3K_Akt
    CSF2RA -->|"activates"| MAPK
    CSF2RA -->|"activates"| STAT1
    
    CSF2 -->|"upregulates"| TLR4
    CSF2 -->|"upregulates"| CXCL10
    CSF2 -->|"upregulates"| S100A8
    CSF2 -->|"upregulates"| FGF2
    
    TLR4 -->|"promotes"| Inflammation
    CXCL10 -->|"promotes"| Inflammation
    S100A8 -->|"promotes"| Inflammation
    
    Pi3K_Akt -->|"promotes"| Neuroprotection
    FGF2 -->|"promotes"| Neuroprotection
    MAPK -->|"promotes"| Microglia
    
    Inflammation -->|"contributes to"| ALS
    Inflammation -->|"contributes to"| MS
    Inflammation -->|"drives"| Neurodegeneration

    style CSF2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Neuroprotection fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style FGF2 fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Pi3K_Akt fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Inflammation fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style Neurodegeneration fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style ALS fill:#7d4200,stroke:#f57c00,stroke-width:2px
    style MS fill:#7d4200,stroke:#f57c00,stroke-width:2px
    style STAT1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style TLR4 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px

Outgoing (100)

Target	Relation	Type	Str
LDLR	associated_with	gene	0.80
ALS	biomarker_for	disease	0.65
Als	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	regulates	disease	0.65
Fibrosis	biomarker_for	disease	0.65
ALS	regulates	disease	0.65
Cancer	activates	disease	0.65
Ubiquitin	regulates	protein	0.60
TNFRSF19	biomarker_for	gene	0.60
App	biomarker_for	protein	0.60
Nf-Κb	activates	pathway	0.60
Interferon Signaling	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
Fibroblast	activates	cell_type	0.60
Il-1	activates	protein	0.60
App	activates	protein	0.60
Raf	associated_with	protein	0.60
App	inhibits	protein	0.60
Microglia	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
Blood-Brain Barrier	associated_with	pathway	0.60
Epithelial	expressed_in	cell_type	0.60
Pdgf	expressed_in	protein	0.60
IL13RA1	co_expressed_with	gene	0.60
Akt	regulates	pathway	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
FGF8	regulates	gene	0.60
TLR4	regulates	gene	0.60
ISG15	regulates	gene	0.60
STAT1	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
S100A8	regulates	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
AKT	regulates	gene	0.60
CXCL2	biomarker_for	gene	0.60
NR4A2	biomarker_for	gene	0.60
P38	regulates	gene	0.60
LDLR	biomarker_for	entity	0.60

Incoming (56)

Source	Relation	Type	Str
AΒ1-42	alters	compound	0.80
SNCA	alters	gene	0.80
CXCL10	regulates	gene	0.60
FGF2	regulates	gene	0.60
PI3K	regulates	gene	0.60
STAT1	regulates	gene	0.60
NAMPT	regulates	gene	0.60
S100A8	regulates	gene	0.60
TLR4	regulates	gene	0.60
FGF8	regulates	gene	0.60
IL1A	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
LDLR	associated_with	gene	0.60
JAK1	biomarker_for	gene	0.60
AKT	regulates	gene	0.60
ERK	regulates	gene	0.60
GENES	regulates	gene	0.60
BCL-2	regulates	gene	0.60
EPOR	regulates	gene	0.60
LGALS9	regulates	gene	0.60
MAPK	regulates	gene	0.60
IL-1	activates	gene	0.60
RNA	activates	gene	0.60
EXOSOMES	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
HSPA1A	regulates	gene	0.60
WTAP	activates	gene	0.60
P38	regulates	gene	0.60
ISG15	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
IL13RA1	biomarker_for	gene	0.60
MSR1	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
CCR9	biomarker_for	gene	0.60
RNA	biomarker_for	gene	0.60
CCR9	co_expressed_with	gene	0.60
MMP9	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
IL1B	activates	gene	0.60
IRAK4	activates	gene	0.60
RANKL	inhibits	gene	0.60
VEGFA	expressed_in	gene	0.60
PDGFB	expressed_in	gene	0.60
TGFB3	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CSF2 in their description or question text

No additional research found