gene

TGFB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGFB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

13Outgoing

18Incoming

0Experiments

0Debates

Summary

Transforming Growth Factor Beta 2 - a cytokine with neuroprotective roles in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	TGFB2
Full Name	Transforming Growth Factor Beta 2
Chromosome	1q41
Function	is a member of the TGF-beta superfamily of cytokines that plays critical roles in neural development, synaptic plasticity, and neuroinflammation regulation[@massague2012][@krieglstein2012].
Molecular Weight	47.7 kDa
Amino Acids	414 aa
Exons	7
Pathways	TGF-β
UniProt ID	P08123
NCBI Gene ID	7048
Ensembl ID	ENSG00000192958
OMIM	190220
GeneCards	TGFB2
Human Protein Atlas	TGFB2
Associated Diseases	Cancer, Carcinoma, Ms, Tumor
Interactions	AND, BMP4, BMP7, TGFBR1
KG Connections	31 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TGFB2 — AlphaFold P08123 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TGFB2 Gene

gene · 990 words

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TGFB2 Protein

protein · 883 words

→

Pathway Diagram

graph TD
    TGFB2["TGFB2"]
    Carcinoma{"Carcinoma"}
    TGFB2 -->|"associated with"| Carcinoma
    Ms{"Ms"}
    TGFB2 -->|"associated with"| Ms
    Cancer{"Cancer"}
    TGFB2 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    TGFB2 -->|"associated with"| Tumor
    BMP7["BMP7"]
    TGFB2 -->|"activates"| BMP7
    neurodegeneration["neurodegeneration"]
    TGFB2 -->|"implicated in"| neurodegeneration
    TGFBR2["TGFBR2"]
    TGFBR2 -->|"associated with"| TGFB2
    BMP4["BMP4"]
    BMP4 -->|"activates"| TGFB2
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| TGFB2
    MYC["MYC"]
    MYC -->|"associated with"| TGFB2
    E2F5["E2F5"]
    E2F5 -->|"associated with"| TGFB2
    CDKN2B["CDKN2B"]
    CDKN2B -->|"associated with"| TGFB2
    TGFBR1["TGFBR1"]
    TGFBR1 -->|"activates"| TGFB2
    CANCER["CANCER"]
    CANCER -->|"associated with"| TGFB2
    BMP2["BMP2"]
    BMP2 -->|"associated with"| TGFB2
    style TGFB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Carcinoma	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
BMP7	activates	gene	0.60
E2F5	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
VEGFB	expressed_in	gene	0.60
CSF2	expressed_in	gene	0.60
Vegf	expressed_in	protein	0.60
Rb	expressed_in	protein	0.60
Epithelial	expressed_in	cell_type	0.60
Pdgf	expressed_in	protein	0.60

Incoming (18)

Source	Relation	Type	Str
VEGFA	expressed_in	gene	0.60
PDGFB	expressed_in	gene	0.60
TGFB3	expressed_in	gene	0.60
TGFB1	expressed_in	gene	0.60
MIRNAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
BMP4	activates	gene	0.60
MYC	associated_with	gene	0.60
E2F5	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
TGFBR1	activates	gene	0.60
BMP2	associated_with	gene	0.60
ITGB8	targets	gene	0.60
AND	activates	gene	0.60
BMP7	activates	gene	0.60
JAG1	targets	gene	0.60
TGFBR2	associated_with	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TGFB2 in their description or question text

No additional research found