protein

VEGFB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VEGFB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

110Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

0Experiments

0Debates

Summary

VEGFB is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with ALS, Als, Arthritis. Connected to 34 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	VEGFB
Full Name	Vascular Endothelial Growth Factor B
Chromosome	11q13.1
Function	VEGFB is a member of the VEGF family:
Molecular Weight	22 kDa
Pathways	Akt, Angiogenesis, Pi3K, Pi3K/Akt, blood-brain barrier
UniProt ID	[P49763](https://www.uniprot.org/uniprot/P49763)
Ensembl ID	ENSG00000173511
GeneCards	VEGFB
Human Protein Atlas	VEGFB
Associated Diseases	Als, Alzheimer, disease
Interactions	AKT, AND, ANGPT1, BMP2, C1R, C1S
KG Connections	110 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

VEGFB Gene

gene · 549 words

→

VEGFB Protein

protein · 618 words

→

Pathway Diagram

graph TD
    VEGFB["VEGFB"]
    Als{"Als"}
    VEGFB -->|"activates"| Als
    Metabolic_Syndrome{"Metabolic Syndrome"}
    VEGFB -->|"regulates"| Metabolic_Syndrome
    Arthritis{"Arthritis"}
    VEGFB -->|"activates"| Arthritis
    ALS{"ALS"}
    VEGFB -->|"activates"| ALS
    Angiogenesis(["Angiogenesis"])
    VEGFB -->|"activates"| Angiogenesis
    VEGF["VEGF"]
    VEGFB -->|"activates"| VEGF
    FGF2["FGF2"]
    VEGFB -->|"activates"| FGF2
    RUNX2["RUNX2"]
    VEGFB -->|"activates"| RUNX2
    PDGFRB["PDGFRB"]
    VEGFB -->|"activates"| PDGFRB
    GENES["GENES"]
    VEGFB -->|"activates"| GENES
    ANGPT1["ANGPT1"]
    VEGFB -->|"activates"| ANGPT1
    BMP2["BMP2"]
    VEGFB -->|"activates"| BMP2
    BMP2 -->|"activates"| VEGFB
    VEGF -->|"activates"| VEGFB
    FGF2 -->|"activates"| VEGFB
    ANGPT1 -->|"activates"| VEGFB
    PDGFRB -->|"activates"| VEGFB
    PI3K["PI3K"]
    PI3K -->|"activates"| VEGFB
    AKT["AKT"]
    AKT -->|"activates"| VEGFB
    RUNX2 -->|"activates"| VEGFB
    GENES -->|"activates"| VEGFB
    AND["AND"]
    AND -->|"activates"| VEGFB
    style VEGFB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
Als	activates	disease	0.75
Fatty Liver	activates	disease	0.65
Insulin Resistance	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
ALS	associated_with	disease	0.65
ALS	activates	disease	0.65
Nafld	activates	disease	0.65
Arthritis	activates	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Endothelial	contributes_to	cell_type	0.60
Rb	activates	protein	0.60
Immune Response	associated_with	pathway	0.60
AND	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
Osteoblast	activates	cell_type	0.60
blood-brain barrier	expressed_in	brain_region	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
VEGFA	associated_with	gene	0.60
Vegf	contributes_to	protein	0.60
RUNX2	activates	gene	0.60
GENES	activates	gene	0.60
IRS1	activates	gene	0.60
Pi3K	activates	pathway	0.60
INSULIN RESISTANCE	regulates	gene	0.60
Pi3K/Akt	activates	pathway	0.60
Myelination	associated_with	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
Akt	activates	pathway	0.60
Stem Cell	activates	cell_type	0.60
Pdgf	activates	protein	0.60
Fgf	activates	protein	0.60
Ras	activates	protein	0.60
ACHE	associated_with	gene	0.60
CSF2	expressed_in	gene	0.60
Vegf	expressed_in	protein	0.60
Rb	expressed_in	protein	0.60
Endothelial	activates	cell_type	0.60
Angiogenesis	activates	pathway	0.60
SMOC2	contributes_to	gene	0.60
Epithelial	expressed_in	cell_type	0.60
Pdgf	expressed_in	protein	0.60
blood-brain barrier	participates_in	pathway	0.60

Incoming (41)

Source	Relation	Type	Str
BMP2	activates	gene	0.60
VEGF	activates	gene	0.60
FGF2	activates	gene	0.60
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
VEGFA	contributes_to	gene	0.60
CLU	associated_with	gene	0.60
CTSF	associated_with	gene	0.60
C1R	interacts_with	gene	0.60
C1S	interacts_with	gene	0.60
CLN5	interacts_with	gene	0.60
CR1	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
SIGLEC9	interacts_with	gene	0.60
SIRPA	interacts_with	gene	0.60
TPP1	interacts_with	gene	0.60
ACHE	implicated_in	gene	0.60
SMOC2	implicated_in	gene	0.60
ANGPT1	expressed_in	entity	0.60
FGF2	expressed_in	entity	0.60
PDGFRB	expressed_in	entity	0.60
GENES	activates	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
SMOC2	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
RUNX2	activates	gene	0.60
ACHE	contributes_to	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CFB	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
VEGFA	expressed_in	gene	0.60
PDGFB	expressed_in	gene	0.60
TGFB3	expressed_in	gene	0.60
TGFB1	expressed_in	gene	0.60
TGFB2	expressed_in	gene	0.60
VEGFA	implicated_in	gene	0.60
SPARC	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VEGFB in their description or question text

No additional research found