concept

PDGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

549Connections

10Hypotheses

1Analyses

50Outgoing

50Incoming

4Experiments

2Debates

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💡 Concept Info

Name	PDGF
Key Genes/Proteins	AB, ABCA1, AD, AIF1, AKT, AMPK
Related Diseases	Als, ALS, ALZHEIMER'S DISEASE, APOPTOSIS
Related Pathways	Akt
Linked Hypotheses	11 hypotheses

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PDGF["PDGF"]
    PDGF -->|"activates"| AKT["AKT"]
    PDGF -->|"activates"| PDGFRB["PDGFRB"]
    PDGF -->|"target for"| Infection["Infection"]
    PDGF -->|"target for"| Carcinoma["Carcinoma"]
    PDGF -->|"target for"| Inflammation["Inflammation"]
    PDGF -->|"activates"| Fibrosis["Fibrosis"]
    PDGF -->|"activates"| Als["Als"]
    PDGF -->|"activates"| Senescence["Senescence"]
    PDGF -.protects against.-> T_CELL["T CELL"]
    Nrf2["Nrf2"] -->|"upregulates"| PDGF
    NRF2["NRF2"] -->|"activates"| PDGF
    LMNA["LMNA"] -->|"activates"| PDGF
    AMYLOID["AMYLOID"] -->|"regulates"| PDGF
    APOE["APOE"] -.biomarker for.-> PDGF
    APOE4["APOE4"] -.biomarker for.-> PDGF
    GFAP["GFAP"] -->|"interacts"| PDGF
    AKT -->|"activates"| PDGF
    EGF["EGF"] -->|"causes"| PDGF
    CSF1R["CSF1R"] -->|"contributes to"| PDGF

Outgoing (243)

Target	Relation	Type	Str
pulmonary artery smooth muscle cell proliferation	promotes	process	0.90
Vascular Remodelling	involved_in	process	0.90
AKT	activates	protein	0.90
IPF	inhibits	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Pulmonary Arterial Hypertension	associated_with	disease	0.80
PDGFRB	activates	gene	0.72
SQSTM1	associated_with	gene	0.70
PI3K/AKT/MTOR	regulates	pathway	0.70
TAU	markers	gene	0.70
WNT	expresses	gene	0.70
PI3K/AKT/MTOR	activates	pathway	0.70
STAT3	interacts_with	gene	0.70
RAGE	activates	gene	0.70
SIRT1	activates	gene	0.70
TFEB	activates	gene	0.70
ULK1	activates	gene	0.70
PERICYTE	biomarker_for	cell_type	0.70
VEGF	activates	gene	0.70
TNF	mediates	gene	0.70
PERICYTES	associated_with	cell_type	0.70
PERICYTE	associated_with	cell_type	0.70
SQSTM1	activates	gene	0.70
TAU	regulates	gene	0.70
TNF	activates	gene	0.70
PERICYTE	treats	cell_type	0.70
PERICYTE	regulates	cell_type	0.70
STROKE	activates	disease	0.70
NEURODEGENERATION	protects_against	phenotype	0.70
PERICYTE	causes	cell_type	0.70
STROKE	inhibits	disease	0.70
PI3K/AKT PATHWAY	causes	pathway	0.70
COGNITIVE DECLINE	causes	phenotype	0.70
COGNITIVE DECLINE	exacerbates	phenotype	0.70
PERICYTE	enhances	cell_type	0.70
pericytes	expressed_in	cell_type	0.65
ALS	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Cardiomyopathy	activates	disease	0.65
Hepatitis	activates	disease	0.65
FIBROBLASTS	activates	cell_type	0.65
ALS	activates	disease	0.65
Cancer	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Infection	therapeutic_target	disease	0.65
VEGF	associated_with	gene	0.65

Incoming (306)

Source	Relation	Type	Str
Nrf2	upregulates	entity	0.95
NFE2L2	upregulates	gene	0.91
NRF2	upregulates	gene	0.90
APOE	regulates	gene	0.70
GPX4	mediates	gene	0.70
DRD1	expresses	gene	0.70
IGF1	interacts_with	gene	0.70
BDNF	associated_with	gene	0.70
CSF1R	expressed_in	gene	0.70
DRD2	expresses	gene	0.70
OLIGODENDROCYTE	regulates	cell_type	0.70
MACROPHAGE	enhances	cell_type	0.70
BDNF	markers	gene	0.70
ENDOTHELIAL	expresses	cell_type	0.70
CSF1R	associated_with	gene	0.70
APOE	biomarker_for	gene	0.70
NEURONS	protects_against	cell_type	0.70
AIF1	associated_with	gene	0.70
ENDOTHELIAL	associated_with	cell_type	0.70
GFAP	associated_with	gene	0.70
IBA1	associated_with	gene	0.70
EGF	associated_with	gene	0.70
BECN1	activates	gene	0.70
CCL2	activates	gene	0.70
CREB	activates	gene	0.70
NFKB	activates	gene	0.70
AMPK	activates	gene	0.70
MACROPHAGE	activates	cell_type	0.70
MICROGLIA	activates	cell_type	0.70
LRP1	expresses	gene	0.70
ASTROCYTE	protects_against	cell_type	0.70
ASTROCYTE	activates	cell_type	0.70
APOPTOSIS	regulates	phenotype	0.70
APP	regulates	gene	0.70
LRP1	regulates	gene	0.65
MICROGLIA	regulates	cell_type	0.65
IGF1	increases	gene	0.65
NRF2	regulates	gene	0.65
NRF2	activates	protein	0.64
LMNA	activates	gene	0.64
GLIOBLASTOMA	co_discussed	disease	0.60
ABCA1	causes	gene	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
MACROPHAGE	interacts_with	cell_type	0.60
NOTCH	associated_with	gene	0.60
MAG	markers	gene	0.60
HIF1A	co_discussed	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYTOKINES	interacts_with	gene	0.60
MMP9	targets	gene	0.60

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.745	-	What blood-brain barrier permeability ch
Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediate	0.705	-	What blood-brain barrier permeability ch
Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.684	neurodegeneration	Perivascular spaces and glymphatic clear
Pericyte-First Sequential Biomarker Cascade — Soluble PDGFR-	0.662	-	Blood-brain barrier permeability changes
Integrated Blood Panel of sPDGFRβ, sTM, and Circulating micr	0.625	-	What blood-brain barrier permeability ch

Circulating Soluble PDGFRβ Reflects Pericyte Loss and Preced	0.625	-	What blood-brain barrier permeability ch
PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-In	0.618	neurodegeneration	How do perivascular cells specifically r
Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Pr	0.600	-	What blood-brain barrier permeability ch
Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulatio	0.480	neurodegeneration	What determines P2RY12 receptor expressi
Cerebral VSMC foam cells induce pericyte detachment via PDGF	0.473	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

neurodegeneration | 2026-04-26 | 5 hypotheses Top: 0.712

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Irisin effects on angiogenesis in human endothelial cells	exploratory	bone fracture	0.900	0.00	human umbilical vein endotheli	proposed	N/A
Proposed experiment from debate on Perivascular spaces and glymphatic	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033]	Levey J, Howe M, Douglas K, Odame E, Raj	bioRxiv : the preprint server	2026	0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335]	Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha	Research (Washington, D.C.)	2026	0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129]	Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu	Clinical & experimental ophtha	2026	0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656]	Jansson D, Highet B, Li S, Stevenson TJ,	Molecular brain	2026	0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244]	Li G, Gao J, Ding P, Gao Y	Journal of advanced research	2025	0
Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407]	Drozd U, Vechkapova S, Lanshakov D	Frontiers in bioscience (Landm	2025	0
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	0
Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655]	Dias DO, Kalkitsas J, Kelahmetoglu Y, Es	Nature communications	2021	0
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288]	Nation DA, Sweeney MD, Montagne A, Sagar	Nature medicine	2019	0
Pericytes in Primary Familial Brain Calcification. [PMID:31147881]	Zarb Y, Franzoso FD, Keller A	Advances in experimental medic	2019	0
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968]	Dias DO, Kim H, Holl D, Werne Solnestam	Cell	2018	0
Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038]	["Fan S", "Geng Q", "Pan Z", "Li X", "Ti	BMC systems biology	2012	0

Debates (2)

Multi-agent debates referencing this entity

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 7 · Score: 0.50 · 2026-04-26

Related Research

Hypotheses and analyses mentioning PDGF in their description or question text

Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline

Score: 0.625 · unknown disease · 2026-04-26

Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo

PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat

Score: 0.618 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The proposed PDGF-BB/PDGFRβ/STAT3 signaling axis represents a complex intercellul

Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Preceding Neurodegener

Score: 0.600 · unknown disease · 2026-04-26

Pericyte degeneration in neurodegeneration leads to proteolytic shedding of the PDGFRβ ectodomain. Soluble PDGFRβ (sPDGF

Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation

Score: 0.480 · neurodegeneration · 2026-04-21

## Mechanistic Overview Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation starts from the claim that modulat

Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance,

Score: 0.473 · neurodegeneration · 2026-04-21

## Mechanistic Overview Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance, impairing neurov

PDGF

Understanding Entity Pages

Wiki Pages (10)

Pericyte PDGFR-Beta Agonist for Neurovascular Rescue

Pericyte PDGFR/VEGFR Modulator Therapy for Neurodegeneration

PDGFRB — Platelet Derived Growth Factor Receptor Beta

PDGF-A Protein

PDGFR-Beta Protein

PDGF-B Protein

PDGFRA — Platelet-Derived Growth Factor Receptor Alpha

PDGFA — Platelet-Derived Growth Factor Subunit A

PDGFRA - Platelet Derived Growth Factor Receptor Alpha

PDGFB — Platelet Derived Growth Factor Subunit B

Pathway Diagram

Outgoing (243)

Incoming (306)

Targeting Hypotheses (10)

Mentioning Analyses (1)

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Experiments (4)

Related Papers (20)

Debates (2)

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

Related Research

Circulating Soluble PDGFRβ Reflects Pericyte Loss and Precedes Cognitive Decline

PDGF-BB/PDGFRβ/STAT3 Paracrine Signaling Axis Mediates Aβ-Induced SPP1 Upregulat

Elevated Circulating sPDGFRβ Reflects Early Pericyte Loss Preceding Neurodegener

Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation

Cerebral VSMC foam cells induce pericyte detachment via PDGF-BB/VEGF imbalance,